Results 11 to 20 of about 20,577 (234)
Stapled truncated orexin peptides as orexin receptor agonists [PDF]
Peptides, 2018 The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations ...
Karhu, Lasse +7 more
core +6 more sources
Orexin, Orexin Receptor Antagonists and Central Cardiovascular Control [PDF]
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity.
Pascal eCarrive
doaj +3 more sources
Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]
The Journal of Neuroscience, 2010 Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka +4 more
openaire +2 more sources
Orexin Receptor Antagonists [PDF]
Current Sleep Medicine Reports, 2017 This paper focuses on the role of orexin receptors in sleep as evidenced in recent preclinical and clinical work. Orexin A and B and their two receptors (OX1R and OX2R) play essential roles in arousal and sleep/wake regulation, addiction, and stress. The absence of orexin producing cells in the lateral hypothalamus or of orexins in the CSF results in ...
B.T. Shireman, M.A. Letavic
openaire +3 more sources
Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection [PDF]
Clinical Science, 2018 Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In the present study, we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects. Quantitative reverse transcription-PCR (RT-PCR), immunohistochemical and Western blot analyses revealed that the rat heart ...
Patel, V +12 more
openaire +7 more sources
Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. [PDF]
PLoS ONE, 2011 At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear.
Janice K V Tam +7 more
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Frontiers in Behavioral Neuroscience, 2022 Orexins (also known as hypocretins) are neuropeptides that participate in the regulation of energy metabolism, homeostasis, sleep, feeding, stress responses, arousal, and reward. Particularly relevant to the scope of the present review is the involvement
Alessandra Matzeu, Rémi Martin-Fardon
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Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress
Brain Sciences, 2023 The endocannabinoid and orexin systems share many biological functions, including wakefulness, stress response, reward processing, and mood. While these systems work against one another with respect to arousal, chronic stress-induced downregulation of ...
Hye Ji J. Kim +5 more
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The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). [PDF]
PLoS ONE, 2014 This study provides a general approach to the presence and possible role of orexins and their receptors in the gut (three gastric chambers and intestine) of confined environment bottlenose dolphin.
Claudia Gatta +9 more
doaj +1 more source
Frontiers in Neuroscience, 2021 The endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep, appetite, pain processing, and emotional behaviors related to reward.
Hye Ji J. Kim +7 more
doaj +1 more source