Genes and primary headaches: discovering new potential therapeutic targets [PDF]
, 2013 Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola +8 more
core +3 more sources
Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]
, 2007 A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G., Woodwark, Mathew
core +1 more source
Expression and potential role of the peptide orexin-A in prostate cancer [PDF]
, 2015 The peptides orexin-A and orexin-B and their G protein-coupled OX1 and OX2 receptors are involved in multiple physiological processes in the central nervous system and peripheral organs.
ASSISI, LOREDANA +11 more
core +1 more source
Kinetic properties of “dual” orexin receptor antagonists at OX1R and OX2R orexin receptors [PDF]
Frontiers in Neuroscience, 2013 Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. Both efficacy and safety are crucial in clinical settings and thorough investigations of pharmacokinetics and pharmacodynamics can predict contributing factors such as duration of action and undesirable effects.
Callander, GE +15 more
openaire +3 more sources
Counterbalanced microcircuits for Orx1 and Orx2 regulation of stress reactivity
Medicine in Drug Discovery, 2020 Orexins are hypothalamic neuropeptides regulating a range of behaviors broadly associated with sleep, motivation, and feeding. These responses highlight the importance of orexins in maintaining foundational biological processes, but also indicate a ...
Jazmine D.W. Yaeger +3 more
doaj +1 more source
Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]
, 2019 CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P. +7 more
core +2 more sources
Presence of orexin A and orexin 1 receptor in the buffalo prostate
Italian Journal of Animal Science, 2010 The orexins A and B are two peptides discovered initially in the rat lateral hypothalamus involved in the regulation of some body functions such as food intake, sleep/wake cycle, arterial pressure and heart rate. They interact with two receptors defined &
A. Vittoria, F. Russo, G. Petrosino
doaj +1 more source
Orexin neurons receive glycinergic innervations. [PDF]
PLoS ONE, 2011 Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood.
Mari Hondo +4 more
doaj +1 more source
Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. [PDF]
, 2014 Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning.
Longordo, F. +4 more
core +1 more source
Considerations about rodent models of binge eating episodes [PDF]
, 2014 A binge eating episode is defined as an uncontrolled event of hyperphagia, in which people quickly eat a large amount of food while feeling a sense of loss of control over eating (Wolfe et al., 2009).
Garcia Romero, Guadalupe +3 more
core +2 more sources