Results 61 to 70 of about 20,577 (234)

Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice

Scientific Reports, 2021
Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect.
Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki   +3 more
doaj   +1 more source

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Subthalamic nucleus stimulation attenuates motor seizures via modulating the nigral orexin pathway

Frontiers in Neuroscience, 2023
BackgroundFocal motor seizures that originate in the motor region are a considerable challenge because of the high risk of permanent motor deficits after resection.
Tao Xue, Shu Wang, Shujun Chen, Huizhi Wang, Chong Liu, Lin Shi, Yutong Bai, Chunkui Zhang, Chunlei Han, Jianguo Zhang, Jianguo Zhang   +10 more
doaj   +1 more source

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 [PDF]

, 2017
Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3′-diindolylmethane. 3,3′-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and
De Vos, Steve, Gosmini, Romain, Hudson, Brian D., Jenkins, Laura, Labéguère, Frédéric, Mahmud, Zobaer Al, Milligan, Graeme, Tikhonova, Irina G., Ulven, Trond   +8 more
core   +3 more sources

OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES [PDF]

, 2015
BACKGROUND: The neuropeptides orexin A and B play a role in reward and feeding and are critical for arousal. However, it was not initially appreciated that most prepro-orexin synthesizing neurons are almost exclusively concentrated in the perifornical
Bonaventure, Pascal, Federici, Lauren M., Fitz, Stephanie D., Johnson, Philip L., Renger, John J., Shekhar, Anantha, Shireman, Brock, Winrow, Christopher J.   +7 more
core   +1 more source

Excessive daytime sleepiness and frequent nightmares are associated with suicidal ideation among psychiatric inpatients

Sleep Research, EarlyView.
Abstract Objectives This study aimed to explore the association between excessive daytime sleepiness (EDS) and frequent nightmares and the risk for suicidal ideation (SI) among psychiatric inpatients. Methods In this cross‐sectional study, 650 inpatients were consecutively recruited from the inpatient department of Shantou University Mental Health ...
Pikun Tan, Jun Wu, Yanyuan Dai, Le Chen, Jiansheng Zhang, Ruifan Shao, Chongtao Xu, Baixin Chen, Yun Li   +8 more
wiley   +1 more source

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Frontiers in Neuroscience, 2014
Orexin/hypocretin peptide mutations are rare in humans. Even though human narcolepsy is associated with orexin deficiency, this is only extremely rarely due to mutations in the gene coding prepro-orexin, the precursor for both orexin peptides.
Miles Douglas Thompson, Henri eXhaard, Takeshi eSakurai, Innocenzo eRainero, Jyrki P. Kukkonen, Jyrki P. Kukkonen   +5 more
doaj   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

Acta Crystallographica Section F, EarlyView.
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima, Chiemi Mishima-Tsumagari, Mayumi Sakata-Sakuta, Ryo Iwaoka, Kunihiko Iwamoto   +4 more
wiley   +1 more source

Orexin Receptors: Pharmacology and Therapeutic Opportunities [PDF]

Annual Review of Pharmacology and Toxicology, 2011
Orexin-A and -B (also known as hypocretin-1 and -2) are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 receptors. In fact, they are necessary for normal wakefulness, as loss of the orexin-producing neurons causes narcolepsy in humans and rodents.
Thomas E, Scammell, Christopher J, Winrow   +1 more
openaire   +2 more sources