Results 31 to 40 of about 13,145 (199)

Common carp (Cyprinus carpio) orexin: Molecular identification, tissue expression, and the role of Orexin-A in glucose metabolism

Aquaculture Reports, 2020
Orexins are neuropeptides involved in energy homeostasis. In fish, the function of orexin-A in glucose metabolism is less reported. The present study aims to identify the potential role of orexin-A in the glucose absorption and metabolism in common carp.
Liping Yang, Shaoyang Zhi, Junyi Hu, Wenlei Zhang, Yuru Zhang, Chaobin Qin, Guokun Yang, Xiao Yan, Guoxing Nie   +8 more
doaj   +1 more source

The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). [PDF]

PLoS ONE, 2014
This study provides a general approach to the presence and possible role of orexins and their receptors in the gut (three gastric chambers and intestine) of confined environment bottlenose dolphin.
Claudia Gatta, Finizia Russo, Maria Grazia Russolillo, Ettore Varricchio, Marina Paolucci, Luciana Castaldo, Carla Lucini, Paolo de Girolamo, Bruno Cozzi, Lucianna Maruccio   +9 more
doaj   +1 more source

Orexin-a elevation in antipsychotic-treated compared to drug-free patients with schizophrenia: A medication effect independent of metabolic syndrome

Journal of the Formosan Medical Association, 2022
Background/Purpose: Orexin-A levels are reportedly increased in antipsychotic (APD)-treated patients with schizophrenia compared to healthy controls and have been associated with metabolic abnormalities.
Po-Yu Chen, Chin-Kuo Chang, Chun-Hsin Chen, Su-Chen Fang, Valeria Mondelli, Chih-Chiang Chiu, Mong-Liang Lu, Ling-Ling Hwang, Ming-Chyi Huang   +8 more
doaj   +1 more source

Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice

eLife, 2019
Uninterrupted arousal is important for survival during threatening situations. Activation of orexin/hypocretin neurons is implicated in sustained arousal.
Srikanta Chowdhury, Chi Jung Hung, Shuntaro Izawa, Ayumu Inutsuka, Meiko Kawamura, Takashi Kawashima, Haruhiko Bito, Itaru Imayoshi, Manabu Abe, Kenji Sakimura, Akihiro Yamanaka   +10 more
doaj   +1 more source

Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling. [PDF]

PLoS ONE, 2016
Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL). Sleep disturbance can negatively impact overall quality of life,
David E Kram, Stephanie M Krasnow, Peter R Levasseur, Xinxia Zhu, Linda C Stork, Daniel L Marks   +5 more
doaj   +1 more source

Orexin expression in different prostate histopathologic examinations: Can it be a marker for prostate cancer? A preliminary result

Urology Research and Practice, 2019
Objective: The aim of this study was to evaluate the expression of the orexin receptor in different prostate pathologies, including prostate adenocarcinoma, benign prostate hyperplasia and chronic prostatitis.
Murad Mehmet Başar, Ünsal Han, Murat Çakan, Serhan Alpcan, Halil Başar   +4 more
doaj   +1 more source

Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson's disease: A retrospective study.

PLoS ONE, 2022
Patients with Parkinson's disease (PD) often suffer from sleep disturbances, including excessive daytime sleepiness (EDS) and rapid eye movement sleep behavior disorder (RBD).
Takuya Ogawa, Yuta Kajiyama, Hideaki Ishido, Shigeru Chiba, Gajanan S Revankar, Tomohito Nakano, Seira Taniguchi, Takashi Kanbayashi, Kensuke Ikenaka, Hideki Mochizuki   +9 more
doaj   +1 more source

Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice

Frontiers in Neuroscience, 2021
The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of histamine neurons is increased in patients with NT1, results on orexin-deficient mouse models ...
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Cristiano Bombardi, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli   +9 more
doaj   +1 more source

Orexin Signaling: A Complex, Multifaceted Process

Frontiers in Cellular Neuroscience, 2022
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B).
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Daniel Hoyer, Daniel Hoyer, Daniel Hoyer, Laura H. Jacobson, Laura H. Jacobson, Laura H. Jacobson, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone   +16 more
doaj   +1 more source

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.

PLoS ONE, 2022
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy.
Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa   +12 more
doaj   +1 more source