Results 51 to 60 of about 18,205 (239)

Orexin Receptor-1 (OX1R)

, 2016
Orexin or hypocretin; a peptide that resembles the molecular structure of the gastric peptide secretin, was discovered in 1996 by two independent groups of researchers.
Selena E. Bartlett, Bartlett, Selena E., Patkar, Omkar L., Omkar L. Patkar, Belmer, Arnauld, Arnauld Belmer   +5 more
core   +1 more source

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease

Brain Pathology, EarlyView.
SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery, Sofia Bergh, Chrisovalantou Huridou, Rachel Y. Cheong, Barbara Baldo, Paul Günther Scheunemann, Marie‐Louisa Schoebel, Linda Holmquist Mengelbier, Elisabet Englund, Catriona McLean, Carsten Saft, Deniz Kirik, Maria Björkqvist, Glenda Halliday, Elisabeth Petrasch‐Parwez, Huu Phuc Nguyen, Jonasz Jeremiasz Weber, Åsa Petersén   +17 more
wiley   +1 more source

Research progress on the mechanism of orexin in pain regulation in different brain regions

Open Life Sciences, 2021
Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]).
Kang Xianhui, Tang Hongli, Liu Yao, Yuan Yan, Wang Mi   +4 more
doaj   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain.

, 2016
An enigmatic feature of behavioural state control is the rich diversity of wake-promoting neural systems. This diversity has been rationalized as 'robustness via redundancy', wherein wakefulness control is not critically dependent on one type of neuron ...
Cornelia Schöne, Denis Burdakov, Burdakov, Denis, Schöne, Cornelia   +3 more
core   +1 more source

Cerebrospinal fluid orexin testing in Australians with narcolepsy type 1

Internal Medicine Journal, EarlyView.
Abstract A clinical diagnosis of narcolepsy type 1 can be challenging, particularly in relation to cataplexy. Despite its specificity, cerebrospinal fluid (CSF) orexin testing is under‐utilised in Australasia. We describe the use of CSF orexin testing in 15 clinically indicated patients from two sleep centres, highlighting its utility in the ...
Mario Fernando, Gianluca Cotta, Samantha Kung, Grace Garden, Jian Eu Tai, Elie Matar, Brendon Yee, Claire Ellender, Sheila Sivam   +8 more
wiley   +1 more source

Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection [PDF]

Clinical Science, 2018
Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In the present study, we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects. Quantitative reverse transcription-PCR (RT-PCR), immunohistochemical and Western blot analyses revealed that the rat heart ...
Patel, V, Karteris, E, Chen, J, Kyrou, I, Mattu, H, Dimitriadis, G, Rodrigo, G, Antoniades, C, Antonopoulos, A, Tan, B, Hillhouse, E, Ng, A, Randeva, H   +12 more
openaire   +6 more sources

Substitution Patterns After Discontinuation of CNS‐Active Medications in Older Adults in Primary Care

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Little is known about substitution of alternative medications in the context of deprescribing. The objectives were to: (1) determine the frequency of medication substitutions among those who discontinued a central nervous system (CNS)‐active medication, and (2) characterize substitutions as potentially inappropriate (as per the 2023
Shelly L. Gray, Annalisa V. Piccorelli, Laura A. Hart, Andrea J. Cook, Brian D. Williamson, Benjamin H. Balderson, Elizabeth A. Phelan   +6 more
wiley   +1 more source

The orexin story and orexin receptor antagonists for the treatment of insomnia

Journal of Sleep Research, 2023
SummaryInsomnia is present in up to one third of the adult population worldwide, and it can present independently or with other medical conditions such as mental, metabolic, or cardiovascular diseases, which highlights the importance of treating this multifaceted disorder. Insomnia is associated with an abnormal state of hyperarousal (increased somatic,
Clemens Muehlan, Catherine Roch, Cedric Vaillant, Jasper Dingemanse   +3 more
openaire   +2 more sources