Frontiers in Physiology, 2022 Orexins are neuropeptides originating from the hypothalamus that serve broad physiological roles, including the regulation of autonomic function, sleep-wake states, arousal and breathing.
Adrienn G. Varga +6 more
doaj +1 more source
Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea
Chronic Diseases and Translational Medicine, EarlyView.Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy +3 more
wiley +1 more source
Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]
, 2007 We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1<sup>-/-(orexin)</sup> mice showed reduced responsiveness to GABA<sub>A</sub> receptor agonists due to a ...
Bernard Bettler +10 more
core +1 more source
Review about comorbidities of behavioural disorders in children and adolescents: The focus on attention-deficit/hyperactivity disorder [PDF]
, 2017 Disruptive behavior disorders (DBD) present high comorbidity rate mainly for opposite-defiant disorders that are frequent among children, adolescents and adults affected by with attention deficit and hyperactivity disorder (ADHD), probably as result of ...
Barbanera F. +9 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing +4 more
wiley +1 more source
The behavioral parenting interventions (BPT) for support and mandatory integrative therapy for children and adolescents affected by disruptive behavioural disorders: A brief review [PDF]
, 2017 The behavioral parenting interventions (BPT), commonly abbreviated as parent training, is a program conducted by an expert with the specific purpose of improving or modifying parental practices in order to promote the child's well-being, increasing ...
Barbanera F. +10 more
core +1 more source
When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions
Movement Disorders, EarlyView.Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel +6 more
wiley +1 more source
Research progress on the mechanism of orexin in pain regulation in different brain regions
Open Life Sciences, 2021 Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]).
Kang Xianhui +4 more
doaj +1 more source
Acute optogenetic silencing of orexin/hypocretin neurons induces slow wave sleep in mice [PDF]
, 2011 Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin (orexin/Halo mice), an orange ...
Boyden, Edward Stuart +5 more
core +1 more source
Advancing pharmacometrics in Africa—Transition from capacity development toward job creation
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai +10 more
wiley +1 more source