Results 1 to 10 of about 13,159 (163)
Orexin, Orexin Receptor Antagonists and Central Cardiovascular Control [PDF]
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity.
Pascal eCarrive
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Evolution of Orexin Neuropeptide System: Structure and Function
Frontiers in Neuroscience, 2020 Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya +2 more
exaly +3 more sources
Melatonin treatment affects leptin and nesfatin-1 levels but not orexin-a levels in rem sleep deprived rats [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 Sleep contributes to the energy balance of body. This study aims to investigate how rapid eye movement (REM) sleep deprivation (SD) or recovery sleep affects rat weight and the serum levels of Nesfatin-1, Orexin-A, and Leptin; additionally, seeks to ...
Aysen CAKIR +3 more
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Effect of plasma isolated Orexin-A on the regulation of metabolites in male rats [PDF]
Iraqi Journal of Veterinary Sciences, 2021 This research includes the isolation and purification of Orexin-A from the plasma of healthy human via various biochemical techniques, it was proposed the therapeutic role of orexin on hyperlipidemia and lipid peroxidation and it has been suggested to ...
Rana F. Jasim, Thikra A. Allwsh
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GABAergic neurons in the nucleus accumbens regulate hedonic food intake via orexin-a expression in the lateral hypothalamus [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): To investigate the regulatory effects of the nucleus accumbens (NAcSh)-lateral hypothalamus (LHA) GABAergic neural pathway on palatable food (PF) intake via orexin-A expression in diet-induced obesity (DIO) rats.
Jieting Kong +10 more
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The Role of Orexin-A in Water Intake in Water-deprived Rats
The Journal of Qazvin University of Medical Sciences, 2022 Background: The lateral hypothalamus (LH), which produces orexin, is vital for body solution homeostasis. Lateral hypothalamus (LH) lesion causes adipsia and its stimulation increases water intake.
Mohammad Hossain Esmaeili +4 more
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Involvement of the Orexinergic System in Feeding
Applied Sciences, 2021 To know the processes involved in feeding, the dysregulation of hypothalamic neuropeptides promoting anorexigenic/orexigenic mechanisms must be investigated. Many neuropeptides are involved in this behavior and in overweight/obesity.
Pilar Marcos, Rafael Coveñas
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Frontiers in Neuroendocrinology, 2018 The neuropeptides orexins are important in regulating the neurobiological systems that respond to stressful stimuli. Furthermore, orexins are known to play a role many of the phenotypes associated with stress-related mental illness such as changes in cognition, sleep-wake states, and appetite.
Laura A, Grafe, Seema, Bhatnagar
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Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]
The Journal of Neuroscience, 2010 Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka +4 more
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Frontiers in Cellular Neuroscience, 2022 BackgroundOrexin-A (OXA) is a polypeptide produced in the hypothalamus, which binds to specific receptors and exerts multiple physiological effects. Autophagy plays a vital role in early brain injury (EBI) after intracerebral hemorrhage (ICH).
Dexin Zhang +8 more
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