Results 21 to 30 of about 81,886,651 (240)

Activity of putative orexin neurons during cataplexy

Molecular Brain, 2022
It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki   +7 more
doaj   +1 more source

Neuropeptides’ Hypothalamic Regulation of Sleep Control in Children Affected by Functional Non-Retentive Fecal Incontinence

Brain Sciences, 2020
Functional non-retentive fecal incontinence (FNRFI) is a common problem in pediatric age. FNRFI is defined as unintended loss of stool in a 4-year-old or older child after organic causes have been excluded.
Vincenzo Monda, Marco Carotenuto, Francesco Precenzano, Diego Iacono, Antonietta Messina, Monica Salerno, Francesco Sessa, Valentina Lanzara, Giovanni Messina, Giuseppe Quatrosi, Rosaria Nardello, Francesca Felicia Operto, Claudia Santoro, Fiorenzo Moscatelli, Chiara Porro, Christian Zammit, Marcellino Monda, Grazia Maria Giovanna Pastorino, Luigi Vetri, Lucia Parisi, Maria Ruberto, Michele Roccella   +21 more
doaj   +1 more source

Involvement of the Orexinergic System in Cancer: Antitumor Strategies and Future Perspectives

Applied Sciences, 2023
Peptides promote the mitogenesis and migration of tumor cells, and cancer cells overexpress peptide receptors. The involvement of the orexinergic system in cancer is reviewed here, including thirteen cancer types (e.g., adrenocortical adenoma, breast ...
Pilar Marcos, Rafael Coveñas
doaj   +1 more source

Integrative Physiology of Orexins and Orexin Receptors

CNS & Neurological Disorders - Drug Targets, 2009
Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
Michihiro, Mieda, Takeshi, Sakurai
openaire   +2 more sources

Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension

Scientific Reports, 2021
Brain orexin system hyperactivity contributes to neurogenic hypertension. We previously reported upregulated neuronal kinin B1 receptor (B1R) expression in hypertension.
Rohan Umesh Parekh, Acacia White, Korin E. Leffler, Vinicia C. Biancardi, Jeffrey B. Eells, Abdel A. Abdel-Rahman, Srinivas Sriramula   +6 more
doaj   +1 more source

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinans bearing multiple effective residues (TriMER) library

, 2021
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors.
Jumpei, Horiuchi, Yasuyuki, Nagumo, Ryuichiro, Oshita, Hiroaki, Gouda, Yukiko, Ishikawa, Yasuo, Uchida, Tetsu, Sato, Hiroshi, Nagase, Tsuyoshi , Saitoh, Akihisa, Tokuda, Takeshi, Sakurai, Noriki, Kutsumura, Masashi, Yanagisawa, Mao, Amezawa, Yasuhiro, Ogawa, Naoshi, Yamamoto, Ryuji, Tanimura, Emi, Hasegawa, Yoko, Irukayama-Tomobe   +18 more
core   +1 more source

Orexin-a elevation in antipsychotic-treated compared to drug-free patients with schizophrenia: A medication effect independent of metabolic syndrome

Journal of the Formosan Medical Association, 2022
Background/Purpose: Orexin-A levels are reportedly increased in antipsychotic (APD)-treated patients with schizophrenia compared to healthy controls and have been associated with metabolic abnormalities.
Po-Yu Chen, Chin-Kuo Chang, Chun-Hsin Chen, Su-Chen Fang, Valeria Mondelli, Chih-Chiang Chiu, Mong-Liang Lu, Ling-Ling Hwang, Ming-Chyi Huang   +8 more
doaj   +1 more source

Evaluation of Orexin-A serum levels in karate athletes cohort [PDF]

, 2020
The lateral hypothalamus products various neuropeptides, among of these the Orexin-A (hypocretin-1) is a protein that regulates numerous physiological and behavioural processes involving in energy balance and metabolic status, physical activity, blood ...
FRANCAVILLA V. C., MONDA V., MESSINA A., DANIELE A., MONDA M., AMETTA A., SESSA F., MESSINA G., POLITO R.   +8 more
core   +1 more source

Orexin system: Network multi-tasking [PDF]

, 2018
Orexin system regulates sleep/wake states and its deficiency result in narcolepsy thus indicating the crucial role of orexins in maintaining wakefulness.
Villano, Ines, Marotta, Rosa, Tripi, Gabriele, Roccella, Michele, Parisi, Lucia, Maldonato, Mauro N., Moscatelli, Fiorenzo, Romano, Palmira, Maltese, Agata, Cerroni, Francesco, Sessa, Francesco, Monda, Vincenzo, Chieffi, Sergio, Valenzano, Anna, Messina, Antonietta, Ruberto, Maria, Monda, Emanuele, Marsala, Gabriella, Monda, Marcellino, Salerno, M, Salerno, Monica, Sperandeo, Raffaele, Cibelli, Giuseppe, Cozzolino, Pasquale, Salerno, Margherita, Messina, Giovanni   +25 more
core   +2 more sources

Common carp (Cyprinus carpio) orexin: Molecular identification, tissue expression, and the role of Orexin-A in glucose metabolism

Aquaculture Reports, 2020
Orexins are neuropeptides involved in energy homeostasis. In fish, the function of orexin-A in glucose metabolism is less reported. The present study aims to identify the potential role of orexin-A in the glucose absorption and metabolism in common carp.
Liping Yang, Shaoyang Zhi, Junyi Hu, Wenlei Zhang, Yuru Zhang, Chaobin Qin, Guokun Yang, Xiao Yan, Guoxing Nie   +8 more
doaj   +1 more source