Results 11 to 20 of about 81,886,651 (240)

Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B [PDF]

Journal of Endocrinology, 2006
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides; however, there are ...
J E, Digby, J, Chen, J Y, Tang, H, Lehnert, R N, Matthews, H S, Randeva   +5 more
openaire   +3 more sources

Presence of orexin A and orexin 1 receptor in the buffalo prostate

Italian Journal of Animal Science, 2010
The orexins A and B are two peptides discovered initially in the rat lateral hypothalamus involved in the regulation of some body functions such as food intake, sleep/wake cycle, arterial pressure and heart rate. They interact with two receptors defined &
A. Vittoria, F. Russo, G. Petrosino
doaj   +2 more sources

Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice [PDF]

eLife, 2019
Uninterrupted arousal is important for survival during threatening situations. Activation of orexin/hypocretin neurons is implicated in sustained arousal.
Srikanta Chowdhury, Chi Jung Hung, Shuntaro Izawa, Ayumu Inutsuka, Meiko Kawamura, Takashi Kawashima, Haruhiko Bito, Itaru Imayoshi, Manabu Abe, Kenji Sakimura, Akihiro Yamanaka   +10 more
doaj   +2 more sources

Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs [PDF]

European Journal of Histochemistry, 2009
The presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques.
C Dall’Aglio, L Pascucci, F Mercati, A Giontella, V Pedini, P Scocco, P Ceccarelli   +6 more
doaj   +2 more sources

The Orexin System Modulates Stress-Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence. [PDF]

Addict Biol
Chronic foot stress increases the vulnerability of adolescent mice to alcohol addiction‐related behaviours. Acute foot stress promotes the recovery of alcohol‐seeking behaviour in adolescent mice and increases orexin concentrations in the hippocampus, nucleus accumbens and prefrontal cortex.
He W, Hu A, Zhao T, Deng L, Wu H, Xiang X.   +5 more
europepmc   +2 more sources

Orexin B Reduces Cerebral Aneurysms Through Inhibition of SP-1. [PDF]

CNS Neurosci Ther
Orexin B/OX2R signaling attenuates cerebral aneurysm formation by suppressing SP‐1‐mediated inflammation, macrophage infiltration, and endothelial adhesion, with OX2R knockdown abolishing these protective effects. The study highlights Orexin B as a therapeutic candidate targeting vascular inflammation and remodeling in aneurysms.
Chen L, Xu J, Ye F, Luo J, Yu H.
europepmc   +2 more sources

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors. [PDF]

Acta Crystallogr F Struct Biol Commun
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Mima M, Mishima-Tsumagari C, Sakata-Sakuta M, Iwaoka R, Iwamoto K.   +4 more
europepmc   +2 more sources

Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone

Brain Sciences, 2022
Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2).
Martin A. Katzman, Matthew P. Katzman
doaj   +1 more source

Context-Dependent Temporal Changes in Hypnotics Involved in Suicide Attempts. [PDF]

Neuropsychopharmacol Rep
Temporal changes in hypnotics involved in suicide attempts showed context‐dependent shifts. Dual orexin receptor antagonists increased significantly, while benzodiazepine involvement declined only in overdose‐related attempts. Melatonin receptor agonists showed no significant trend during 2020.
Sasaki T, Sugawara N, Furukawa M, Iwaki H, Suda S, Yasui-Furukori N.   +5 more
europepmc   +2 more sources

In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B

, 2023
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are currently being developed to treat insomnia and narcolepsy.
Rosalba, Sortino, Diane, Nepomuceno, Ernest, Giralt, Alexandre, Gomila-Juaneda, Pascal, Bonaventure, Davia, Prischich, Carlo, Matera, Pau, Gorostiza, Salvador, Guardiola, Luis, de Lecea, Monica, Varese   +10 more
core   +1 more source