Results 41 to 50 of about 81,886,651 (240)

The Regulation of Sleep and Wakefulness by the Hypothalamic Neuropeptide Orexin/Hypocretin [PDF]

, 2013
2013-02Orexins, also known as hypocretins, are neuropeptides that are exclusively expressed by neurons in the lateral hypothalamic area. Although originally recognized as regulators of feeding behavior, orexins are now mainly regarded as key modulators ...
YAMANAKA, AKIHIRO, INUTSUKA, AYUMU
core   +1 more source

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.

PLoS ONE, 2022
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy.
Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa   +12 more
doaj   +1 more source

Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. [PDF]

PLoS ONE, 2013
Both orexin and neurotensin are expressed in the lateral hypothalamic area (LHA) and have been implicated in the regulation of feeding, motor activity and the reward system.
Naoki Furutani, Mari Hondo, Haruaki Kageyama, Natsuko Tsujino, Michihiro Mieda, Masashi Yanagisawa, Seiji Shioda, Takeshi Sakurai   +7 more
doaj   +1 more source

Orexin A induces bidirectional modulation of synaptic plasticity: Inhibiting long-term potentiation and preventing depotentiation

, 2017
The orexin system consists of two peptides, orexin A and B and two receptors, OX1R and OX2R. It is implicated in learning and memory regulation while controversy remains on its role in modulating hippocampal synaptic plasticity in vivo and in vitro. Here,
Lu, Guan-Ling;Lee, Chia-Hsu;Chiou, Lih-Chu, 邱麗珠   +1 more
core   +1 more source

Mechanism by which low-intensity focused ultrasound promotes angiogenesis and neurogenesis after traumatic brain injury in a rat model via the OXA/MAPK signaling pathway

Neural Regeneration Research
Low-intensity focused ultrasound is a type of ultrasound that primarily relies on cavitation and mechanical effects. It is non-invasive, transient, and well tolerated.
Bingkai Ren, Junwei Kang, Peng Yao, Lianghua Huang, Yan Wang, Yang Bai, Zhen Feng   +6 more
doaj   +1 more source

Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray

, 2017
The orexin system consists of orexin A/hypocretin 1 and orexin B/hypocretin 2, and OX1 and OX2 receptors. Our previous electrophysiological study showed that orexin A in the rat ventrolateral periaqueductal gray (vlPAG) induced antinociception via an OX1
邱麗珠, Lee, Hsin-Jung;Chang, Lu-Yang;Ho, Yu-Cheng;Teng, Shu-Fang;Hwang, Ling-Ling;Mackie, Ken;Chiou, Lih-Chu   +1 more
core   +1 more source

Salivary biomarkers in sleep‐related disorders

Sleep Research, EarlyView.
Abstract The exploration of salivary biomarkers has emerged as a promising avenue in the diagnosis and management of sleep‐related disorders, such as obstructive sleep apnea (OSA), insomnia, and sleep deprivation. Saliva is a noninvasive biofluid that contains a wealth of biological markers, reflecting both local and systemic physiological changes ...
Chuan Xiang Li, Yi Wang, Ying Ni Lin, Jun Qi Lin, Ya Ru Yan, Xian wen Sun, Liu Zhang, Shi Qi Li, Ning Li, Qing Yun Li   +9 more
wiley   +1 more source

Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain.

, 2016
An enigmatic feature of behavioural state control is the rich diversity of wake-promoting neural systems. This diversity has been rationalized as 'robustness via redundancy', wherein wakefulness control is not critically dependent on one type of neuron ...
Cornelia Schöne, Denis Burdakov, Burdakov, Denis, Schöne, Cornelia   +3 more
core   +1 more source

Orexin, cardio-respiratory function and hypertension

Frontiers in Neuroscience, 2014
In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. 1) Orexin, cardiovascular function and hypertension.
Aihua eLi, Eugene E Nattie
doaj   +1 more source

Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review

Brain Circulation, 2020
Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex concerned in the wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin.
Hayder M Al-Kuraishy, May H Abdulhadi, Nawar R Hussien, Marwa S Al-Niemi, Huda A Rasheed, Ali I Al-Gareeb   +5 more
doaj   +1 more source