Results 61 to 70 of about 81,886,651 (240)

Alterations in PGC-1α and UCP1 Gene Expression in Epicardial Aadipose Tissue and Serum Orexin-A Following Aerobic Exercise in High-Fat Diet Induced Obesity of Male Wistar Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2020
BACKGROUND AND OBJECTIVE: Due to the proximity of epicardial adipose tissue (EAT) to the myocardial tissue, it is considered that EAT be more pathogenic than subcutaneous adipose tissue.
E Moslehi, V Minasian, H Sadeghi
doaj  

Roles of orexin in modulating arousal, feeding and motivation

Frontiers in Behavioral Neuroscience, 2013
Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.
Natsuko eTsujino, Takeshi eSakurai
doaj   +1 more source

A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia

npj Genomic Medicine, 2022
Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which is a well-defined type of central disorders of hypersomnolence, the etiology of IH is poorly ...
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda   +43 more
doaj   +1 more source

Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann, Raphael J. Dressle, Fee Benz, Kai Spiegelhalder, Anna F. Johann, Christoph Nissen, Elisabeth Hertenstein, Chiara Baglioni, Laura Palagini, Lukas Krone, Michael L. Perlis, Katharina Domschke, Mathias Berger, Bernd Feige   +13 more
wiley   +1 more source

Orexin Receptor-1 (OX1R)

, 2016
Orexin or hypocretin; a peptide that resembles the molecular structure of the gastric peptide secretin, was discovered in 1996 by two independent groups of researchers.
Selena E. Bartlett, Bartlett, Selena E., Patkar, Omkar L., Omkar L. Patkar, Belmer, Arnauld, Arnauld Belmer   +5 more
core   +1 more source

Changes in the orexin system, hypothalamic-pituitary-adrenal axis and circadian rhythm in juvenile-stressed rats

Journal of Pharmacological Sciences
The orexin system has been demonstrated to play various physiological roles, such as in feeding, sleep, and autonomic neural function. Clinically, orexin receptor antagonists are used as hypnotics, and several clinical trials have suggested their ...
Kazune Ozaki, Shinya Nishiide, Hiroki Shikanai, Tsugumi Shindo, Riho Mabuchi, Satoshi Shinozuka, Takeshi Izumi   +6 more
doaj   +1 more source

Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection [PDF]

Clinical Science, 2018
Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In the present study, we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects. Quantitative reverse transcription-PCR (RT-PCR), immunohistochemical and Western blot analyses revealed that the rat heart ...
Patel, V, Karteris, E, Chen, J, Kyrou, I, Mattu, H, Dimitriadis, G, Rodrigo, G, Antoniades, C, Antonopoulos, A, Tan, B, Hillhouse, E, Ng, A, Randeva, H   +12 more
openaire   +6 more sources

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Role of Orexin System in Obesity [PDF]

, 2015
Obesity is a public health disease and its incidence is steadily increasing both in adults and in children especially in the Western World. It is important to understand the underlying mechanisms of obesity and possible treatments as the orexin system ...
Moscatelli, F, Messina, G., Varriale, B, Esposito, T., Monda, G., CIBELLI, GIUSEPPE, Cibelli, G, Barillari, MR, Monda, Vincenzo, Messina, A, Messina, G, Chieffi, S, Esposito, T, Monda, V, Chieffi, S., Valenzano, A, Monda, M., Tafuri, D., De Blasio, S, Barillari, M. R., Valenzano, A., Messina, A., De Blasio, S., Varriale, B., TAFURI, Domenico, Monda, G, Moscatelli, F.   +26 more
core   +2 more sources

Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease

Frontiers in Neuroscience, 2018
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive and selective death of dopaminergic neurons. Orexin-A is involved in many biological effects of the body.
Mei-Fang Liu, Mei-Fang Liu, Yan Xue, Cui Liu, Yun-Hai Liu, Hui-Ling Diao, Ying Wang, Yi-Peng Pan, Lei Chen   +8 more
doaj   +1 more source