Results 81 to 90 of about 81,886,651 (240)

Investigation of the “Not Better Explained” Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review

Journal of Sleep Research, EarlyView.
The “Not Better Explained” (NBE) criterion plays a key role in preventing diagnostic misclassification by structuring causal reasoning in sleep medicine. This systematic content analysis compares the use, wording, and excluded conditions of NBE criteria across the ICSD‐3‐TR and DSM‐5‐TR for ten major sleep disorders.
Jean‐Arthur Micoulaud‐Franchi, Vincent P. Martin, Julien Coelho, Régis Lopez, Pierre‐Alexis Geoffroy, Laure Peter‐Derex, Isabelle Lambert, Charles M. Morin, Clélia Quiles, Christophe Gauld   +9 more
wiley   +1 more source

Design and synthesis of orexin 1 receptor-selective agonists

, 2022
Orexins are a family of neuropeptides that regulate various physiological events such as sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein-coupled receptors, i.e., the orexin 1 (OX1R) and orexin 2 receptors (OX2R).
Yasuyuki, Nagumo, Yukiko, Ishikawa, Hiroshi, Nagase, Naoshi, Yamamoto, Tsuyoshi, Saitoh, Kao, Hashimoto, Keita, Iio, Taisei, Hasegawa, Noriki, Kutsumura, Katsuhiko, Takeuchi, Masashi, Yanagisawa, Mao, Amezawa   +11 more
core   +1 more source

Risks Associated With Benzodiazepine Long‐Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT This systematic literature review evaluated the risks of using benzodiazepine medications for more than 3 months in adults with chronic insomnia. Chronic insomnia is defined as ongoing dissatisfaction with sleep quantity or quality, causing significant distress and impaired functioning during the day.
Dieter Riemann, Chiara Baglioni, Christoph Nissen, Agathe Nevière, Omar Irfan, Pauline Le Nouveau, Chrysoula Leontiou, Damien Léger   +7 more
wiley   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Ken-ichi Yagami, Bernard Bettler, Thomas Kilduff, Satoshi Kunita, Hitomi Takahira, Taizo Matsuki, Mika Nomiyama, Takeshi Sakurai, Noriko Hirashima, Satoru Takahashi, Masashi Yanagisawa   +10 more
core  

Post‐ICU Psychotropic Medication Initiation in Nonagenarian Sepsis Survivors

Journal of the American Geriatrics Society, EarlyView.
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki   +2 more
wiley   +1 more source

Lights On or Off? The Efficacy of Light Therapy as Add‐On to Cognitive Behavioural Therapy for Insomnia—A Pilot Study

Journal of Sleep Research, EarlyView.
ABSTRACT Cognitive behavioural therapy for insomnia (CBT‐I) is recommended as first‐line treatment for insomnia disorder. However, around 25% of the patients do not respond to the treatment, and only 40% achieve full remission. The current study investigates the therapeutic potential of light therapy as an add‐on to CBT‐I.
Sarah R. Schmid, Christine Blume, Johanna Ell, Nikolas Konzen, Matthias Apweiler, Bernd Feige, Bernd L. Fiebich, Julian E. Schiel, Katharina Domschke, Kai Spiegelhalder   +9 more
wiley   +1 more source

Does Sleep Curtailment Stimulate Appetite, Motivation to Eat and Dietary Intake in Humans? A Narrative Synthesis of Evidence and Considerations for Future Studies

Journal of Sleep Research, EarlyView.
ABSTRACT Insufficient sleep has been increasingly recognised as a risk factor for obesity, yet the underlying mechanisms remain incompletely understood. Research suggests that sleep restriction promotes excessive dietary intake, and it is commonly assumed that this relationship can be explained by appetite dysregulation.
Sze‐Yen Tan, Isabella Emillya Tjahjono, Ilili Feyesa, Jeew Hettiarachchi, Nahyun Kim, Reagan Pennycuff, Amani Qawasmeh, Robin M. Tucker   +7 more
wiley   +1 more source

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Orexin-A increases the differentiation of human olfactory sensory neurons through orexin receptor type 1

Regenerative Therapy
Introduction: Sensorineural olfactory dysfunction significantly impairs the life quality of patients but without effective treatments to date. Orexin is a neurotrophic factor activates neuronal network activity.
Yin-Tzu Chen, Tai-Horng Young, Yu-Hsin Wang, Chih-Hsuan Huang, Yu-Yun Gao, Tsung-Wei Huang   +5 more
doaj   +1 more source

Orexin A ameliorates HBV X protein-induced cytotoxicity and inflammatory response in human hepatocytes

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hepatitis B virus is one of the main causes of hepatitis and hepatocellular carcinoma (HCC). Hepatitis B virus-encoded X protein (HBx) has been shown to be involved in many aspects of the pathogenicity of liver diseases.
Li Wang, Tao He, Baishun Wan, Xiaoqian Wang, Ling Zhang   +4 more
doaj   +1 more source