Results 101 to 110 of about 17,739 (247)

Orexin-A increases the differentiation of human olfactory sensory neurons through orexin receptor type 1

Regenerative Therapy
Introduction: Sensorineural olfactory dysfunction significantly impairs the life quality of patients but without effective treatments to date. Orexin is a neurotrophic factor activates neuronal network activity.
Yin-Tzu Chen, Tai-Horng Young, Yu-Hsin Wang, Chih-Hsuan Huang, Yu-Yun Gao, Tsung-Wei Huang   +5 more
doaj   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Localization of orexin B and orexin-2 receptor in the rat epididymis [PDF]

, 2018
The peptides orexin A (OXA) and orexin B (OXB) derived from the proteolytic cleavage of a common precursor molecule, prepro-orexin, were originally described in the rat hypothalamus.
Alfredo Vittoria, Anna Costagliola, Caterina Squillacioti, Chika Miyoshi, Giovanna Liguori, Masashi Yanagisawa, Nicola Mirabella, Simona Tafuri, Valeria De Pasquale   +8 more
core   +1 more source

Overnight Dynamics of Ventricular Cerebrospinal Fluid Amyloid‐Beta, Lactate and Hypocretin in Patients With Hydrocephalus: A Pilot Study

Journal of Sleep Research, EarlyView.
ABSTRACT This pilot observational study evaluated whether frequent overnight sampling of ventricular cerebrospinal fluid could clarify how sleep, hypocretin and lactate relate to amyloid‐β42 dynamics in adults with hydrocephalus. Seven participants underwent hourly ventricular cerebrospinal fluid sampling from early evening to late morning during ...
Casper Schwartz Riedel, Joachim Birch Milan, Niklas Rye Jørgensen, Poul Jennum, Marianne Juhler   +4 more
wiley   +1 more source

Investigation of the “Not Better Explained” Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review

Journal of Sleep Research, EarlyView.
The “Not Better Explained” (NBE) criterion plays a key role in preventing diagnostic misclassification by structuring causal reasoning in sleep medicine. This systematic content analysis compares the use, wording, and excluded conditions of NBE criteria across the ICSD‐3‐TR and DSM‐5‐TR for ten major sleep disorders.
Jean‐Arthur Micoulaud‐Franchi, Vincent P. Martin, Julien Coelho, Régis Lopez, Pierre‐Alexis Geoffroy, Laure Peter‐Derex, Isabelle Lambert, Charles M. Morin, Clélia Quiles, Christophe Gauld   +9 more
wiley   +1 more source

Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. [PDF]

, 2014
Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning.
Longordo, F., Lüthi, A., Massonnet, C., Perin, M., Welker, E.   +4 more
core   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

A brief review about anxiety and aggressive behavior in pediatric age [PDF]

, 2018
Anxiety can be considered a normal experience of the human being and as such also of the child. It manifests itself in different ways according to the level of development: in the smaller the child, the more anxiety is expressed with manifestations that ...
Cerroni F., Chisari M. G., Cibelli G., Di Folco A., Franco S., Gallai B., Geraci D., Giugliano P., Grieco M., Lavano F., Lavano S. M., Magliulo R. M., Marotta R., Marsala G., Montana A., Murabito P., Parisi L., Picciocchi E., Polito A. N., Ro L., Romano P., Russo D., Salerno M., Sorrentino M., Testa D., Tripi G., Valenzano A.   +26 more
core  

Context‐Dependent Temporal Changes in Hypnotics Involved in Suicide Attempts

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Temporal changes in hypnotics involved in suicide attempts showed context‐dependent shifts. Dual orexin receptor antagonists increased significantly, while benzodiazepine involvement declined only in overdose‐related attempts. Melatonin receptor agonists showed no significant trend during 2020.
Taro Sasaki, Norio Sugawara, Motoharu Furukawa, Hirotaka Iwaki, Shiro Suda, Norio Yasui‐Furukori   +5 more
wiley   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Bernard Bettler, Hitomi Takahira, Ken-ichi Yagami, Masashi Yanagisawa, Mika Nomiyama, Noriko Hirashima, Satoru Takahashi, Satoshi Kunita, Taizo Matsuki, Takeshi Sakurai, Thomas Kilduff   +10 more
core   +1 more source