Results 101 to 110 of about 81,886,651 (240)

Orexin A attenuates unconditioned sexual motivation in male rats

, 2009
Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation.
Bai, Y. J., Sui, N., Han, J., Li, Y. H., N. Sui, Yang, X. Y., Zheng, X. G.   +6 more
core  

The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System

, 2020
The accumulation of adipose tissue represents one of the characteristics of obesity, increasing the risk of developing correlated obesity diseases such as cardiovascular disease, type 2 diabetes, cancer, and immune diseases.
Campanozzi A., Messina G., Ambrosi A., Cibelli G., Tafuri D., Monda M., Valenzano A., Messina A., Sessa F., Tartaglia N., Polito R., Monda V.   +11 more
core   +2 more sources

Stapled truncated orexin peptides as orexin receptor agonists

Peptides, 2018
The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity.
Karhu, L, Weisell, J, Turunen, PM, Leino, TO, Pätsi, H, Xhaard, H, Kukkonen, JP, Wallén, EAA   +7 more
openaire   +5 more sources

The role of orexin system in antipsychotics induced weight gain.

, 2011
: Weight gain in schizophrenia patients is becoming a major concern as second-generation antipsychotics (SGAs) have been associated with a considerable increase in weight. The mechanisms by which they produce this side effect are not known. The orexins
Panariello F, Viggiano A, MONDA, Marcellino, Teo C., De Luca V., Javaid N., Panariello F., Monda M., Viggiano A., Javaid N, Teo C   +10 more
core   +1 more source

An electrophysiological study of Orexin A and [Ala11, D-Leu15] orexin-B effects in rat periaqueductal gray slices

, 2007
Orexins，又稱做hypocretins，是在1998年所發現的神經胜肽，有兩個成員，orexin A( hypocretin 1 )及orexin B( hypocretin 2 )。Orexin A是由33個胺基酸所組成，並且有兩個雙硫鍵，而orexin B則是28個胺基酸所組成；orexin A及orexin B的胺基酸序列的同源相似性為46%。 Orexin受體屬於G蛋白偶合受體( G-protein coupled receptor )，有兩種亞型，分別是OX1R及OX2R ...
Fu, Szu-Ying, 傅思穎
core  

Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

, 2016
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 ...
Annette G. Beck-Sickinger (92957), Richard M. Söll (2724037), Manja Lang (2141818), Frank M. Dautzenberg (2724040), Franz Dürrenberger (2724043)   +4 more
core   +1 more source

Gallic Acid‐Mediated Enhancement of Diazepam‐Induced Sedation via GABAA Receptor Modulation: In Vivo and In Silico Evaluation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Noshin Tasnim Yana, Anike Chakrabarty, Chinmoy Kumar Saha, Nikhat Jamal Siddiqi, Norah Alnazhan, Md. Sakib Al Hasan, Feroz Khan Nun, Imam Hossen Rakib, Md. Nasimul Haque Shipon, Emon Mia, Md Asaduzzaman Jony, Ali Mohamod Wasaf Hasan, Muhammad Torequl Islam, Azmat Ali Khan   +13 more
wiley   +1 more source

Exercise increases the level of plasma orexin A in humans

, 2016
The purpose of this research was to study the effects of exercise on the concentration of plasma orexin A, a peptide regulating several physiological functions.
Messina G., Chieffi S., De Luca V., Monda M., Viggiano A., Messina A., Galderisi U., Di Bernardo G., Monda V.   +8 more
core   +1 more source

Associations of Cerebrospinal Fluid Orexin‐A, Alzheimer Disease Biomarkers, and Cognitive Performance

Annals of Clinical and Translational Neurology
Objective Cerebrospinal fluid (CSF) orexin‐A has been suggested to be a biomarker of Alzheimer disease (AD). In both cognitively unimpaired healthy older adults and individuals with symptomatic AD, CSF orexin‐A is positively associated with CSF Aβ42, p ...
Ruijin Lu, Krish Shah, Cristina D. Toedebusch, Ashley Hess, Rachel Richardson, Emmanuel Mignot, Suzanne E. Schindler, Tammie L. S. Benzinger, Shaney Flores, Jason Hassenstab, Chengjie Xiong, John C. Morris, David M. Holtzman, Brendan P. Lucey   +13 more
doaj   +1 more source

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

Movement Disorders, Volume 41, Issue 6, Page 1337-1348, June 2026.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel, Robert S. Eisinger, Joyce M. Lee, Sarah Hamimi, Hope Kim, Susanna D. Howard, Casey H. Halpern   +6 more
wiley   +1 more source