Results 111 to 120 of about 81,886,651 (240)

Hyperthermic reactions induced by orexin A: role of the ventromedial hypothalamus.

, 2005
This experiment tested the involvement of the ventromedial hypothalamus (VMH) in the sympathetic and hyperthermic reactions induced by an intracerebroventricular (i.c.v.) injection of orexin A (1.5 nmol).
VIGGIANO, Andrea, E. Viggiano, A. Viggiano, V. D. Luca, M. Monda, A. Lanza   +5 more
core   +1 more source

Orexin and Alzheimer’s Disease

, 2016
Alzheimer's disease (AD) is the most frequent age-related dementia. It prevalently causes cognitive decline, although it is frequently associated with secondary behavioral disturbances. AD neurodegeneration characteristically produces a remarkable destruction of the sleep-wake cycle, with diurnal napping, nighttime arousals, sleep fragmentation, and ...
openaire   +3 more sources

The Orexin-A serum levels are strongly modulated by physical activity intervention in diabetes mellitus patients

, 2020
The Orexin-A (hypocretin-1) is a neuropeptide secreted by neurons in the lateral hypothalamus. This protein regulates physiological and behavioural processes that have an essential impact on energy balance and metabolic status, physical activity, blood ...
Scarinci A., Francavilla V. C., Tafuri D., Monda M., Di Maio G., Sessa F., Polito R., Tartaglia N., Messina G., Ametta A., Ambrosi A., Messina A., Monda V.   +12 more
core   +1 more source

The Effect of Porcine Orexin a on Glucose-Dependent Insulinotropic Polypeptide Plasma Concentrations in Pigs

European Journal of Inflammation, 2010
The orexigenic system was discovered in 1998. It consists of two neuropeptides, Orexin A and Orexin B. Researchers have focused more on Orexin A, since its intracerebroventricular injection into the lateral ventricle of the rat's brain causes an increase
P. Papakonstantinou, N. Tziris, D. Kapoukranidou, A. Gotzamani-Psarrakou, C.H.R. Tsonidis, M.N. Patsikas, G. Papazoglou   +6 more
doaj   +1 more source

Excessive daytime sleepiness and frequent nightmares are associated with suicidal ideation among psychiatric inpatients

Sleep Research, Volume 3, Issue 2, Page 161-169, June 2026.
Abstract Objectives This study aimed to explore the association between excessive daytime sleepiness (EDS) and frequent nightmares and the risk for suicidal ideation (SI) among psychiatric inpatients. Methods In this cross‐sectional study, 650 inpatients were consecutively recruited from the inpatient department of Shantou University Mental Health ...
Pikun Tan, Jun Wu, Yanyuan Dai, Le Chen, Jiansheng Zhang, Ruifan Shao, Chongtao Xu, Baixin Chen, Yun Li   +8 more
wiley   +1 more source

Dynamic Interactions between Orexin and Dynorphin May Delay Onset of Functional Orexin Effects: A Modeling Study

, 2011
Orexin (also known as hypocretin) neurons play a key role in regulating sleep-wake behavior, but the links between orexin neuron electrophysiology and function have not been explored.
Katherine S. Williams, Cecilia G. Diniz Behn   +1 more
core   +1 more source

Relationship Between Cognitive Impairments and Serum Orexin Levels in Epilepsy Patients

Archives of Epilepsy
Objective: Recent studies on neurodegenerative diseases have indicated that Orexin A plays a role in cognitive impairment. Furthermore, animal studies have demonstrated that Orexin A enhances synaptic plasticity in the hippocampus.
Zeliha Yücel, İrem Fatma Uludağ, Ufuk Şener, Alp Sarıteke, Anıl Baysoy   +4 more
doaj   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review

European Journal of Neurology, Volume 33, Issue 6, June 2026.
This graphical abstract presents the review process (including 41 studies). It highlights the use of machine learning techniques in adults with CDH, such as unsupervised learning for phenotype discovery and supervised learning for diagnosis classification. The figure summarizes the strengths and limitations of each approach, along with key clinical and
Annina Helmy, Livia G. Fregolente, Marc von Gernler, Rafael Morand, Julia van der Meer, Markus Schmidt, Stavroula Mougiakakou, Athina Tzovara, Claudio L. A. Bassetti   +8 more
wiley   +1 more source

The role of orexin A in the pathogenesis of ischaemic stroke at high altitude

Experimental Physiology
Orexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression. This study aimed to investigate the effect of high altitude on orexin expression and its pathophysiological ...
Minxia Zhu, Xu Guo, Jing Guo, Zhaojun Zhang, Kexin Zhang, Yaqi Lei, Yuhe Wang, Haoshuang Zhan   +7 more
doaj   +1 more source