Results 111 to 120 of about 17,739 (247)

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Central orexin-A increases colonic motility in conscious rats

Neuroscience Letters, 2011
Increasing evidence has indicated that brain orexin plays a vital role in the regulation of gastrointestinal physiology such as gastric secretion, gastric motility and pancreatic secretion. However, little is known whether orexin in the brain is involved in the physiology of the lower gastrointestinal tract.
Nozu, Tsukasa, Kumei, Shima, Takakusaki, Kaoru, Ataka, Koji, Fujimiya, Mineko, Okumura, Toshikatsu   +5 more
openaire   +3 more sources

Differential Roles of Each Orexin Receptor Signaling in Obesity

iScience, 2019
Summary: Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here,
Miyo Kakizaki, Yousuke Tsuneoka, Kenkichi Takase, Staci J. Kim, Jinhwan Choi, Aya Ikkyu, Manabu Abe, Kenji Sakimura, Masashi Yanagisawa, Hiromasa Funato   +9 more
doaj   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

Separaxion anxiety in pediatric migraine without aura: A pilot study [PDF]

, 2017
Background: Separation anxiety (SA) can be defined as the fear reaction and protest manifested by children when the main caregivers move away from him/her or in front of unfamiliar person. SA near eight months may be considered as an important and normal
Di Filippo T., Di Folco A., Gabriele Tripi, Maltese A., Parisi L., Romano P., Salerno M.   +6 more
core   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individuals

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1473-1486, May 2026.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Expression of orexin B and its receptor 2 in rat testis [PDF]

, 2017
The peptides orexin A (OxA) and orexin B (OxB) deriving from a common precursor molecule, prepro-orexin, by proteolytic cleavage, bind the two G-coupled OX1 and OX2 receptors.
ASSISI, LOREDANA, COSTAGLIOLA, ANNA, Langella, Emilia, LIGUORI, GIOVANNA, MIRABELLA, NICOLA, PAVONE, LUIGI MICHELE, TAFURI, SIMONA, VITTORIA, ALFREDO   +7 more
core   +1 more source

Effectiveness of Melatonin‐Containing Foods on Promoting Sleep: A Scoping Review

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Effectiveness of melatonin‐containing foods promoting sleep: A scoping review. ABSTRACT Melatonin plays a crucial role in managing the body's sleep–wake cycle, and its natural occurrence in certain foods has generated interest in dietary interventions to improve sleep.
Tanzeela Nisar, Andrea Fuller, Prajwal Gyawali, Stephen Bird   +3 more
wiley   +1 more source

Transcranial magnetic stimulation (TMS) application in sport medicine: A brief review [PDF]

, 2017
Since 1985, transcranial magnetic stimulation (TMS) has been used for non-invasive exploration of motor control in humans and for a wide range of applications in all ages of life.
Chieffi, S., Messina, A., Monda, E., Monda, G., Monda, V., Moscatelli, F., Parisi, L., Roccella, M., Ruberto, M., Triggiani, A., Valenzano, A., Villano, I.   +11 more
core   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source