Results 121 to 130 of about 81,886,651 (240)

Chronic Insomnia and Excess Cannabis Ingestion in an Older Adult—A Clinical Report of Complex Geriatric Care

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1841-1844, June 2026.
Cannabis use in older adults may have a broad range of effects in older adults impacting Mind, Mobility, Medications, Multi‐complexity, and what Matters Most.
Erik Fraunberger, Maia von Maltzahn
wiley   +1 more source

Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in IP rats

, 2016
Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in IP ...
SYS Khoo (15829220), Jee Hyun Kim (13075509), RM Brown (14449740), B Jupp (13478248), AK Kim (15829217), AJ Lawrence (5578280)   +5 more
core  

Cerebrospinal-fluid orexin levels and daytime somnolence in frontotemporal dementia

, 2014
Daytime somnolence and sleep-wake cycle disturbances are commonly encountered symptoms in Frontotemporal Dementia (FTD). Orexin-A (Hypocretin-1) is a hypothalamic neuropeptide regulating the sleep-wake rhythm. We investigated the cerebrospinal-fluid (CSF)
Nuccetelli, M, MARCIANI, MARIA GRAZIA, MERCURI, NICOLA BIAGIO, Liguori, C, Sancesario, G, MARTORANA, ALESSANDRO, BERNARDINI, SERGIO, SANCESARIO, GIUSEPPE, PLACIDI, FABIO, Albanese, M, Romigi, A, Izzi, F   +11 more
core   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, Volume 604, Issue 11, Page 4338-4377, 1 June 2026.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Scientific Reports
Tunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (ATR).
Maiju K. Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M. Riddy, Christopher J. Langmead, Jyrki P. Kukkonen, Henri Xhaard   +7 more
doaj   +1 more source

The Role of Orexin in Stress

, 2010
Orexins (hypocretins) are novel neuropeptides released by some neurons identified in lateral hypothalamus. They are involved in the regulation of energy metabolism, neuroendocrine, sleep and waking.
Han Jin, Sui Nan, Wang Hui-Ying, Wei Chu-Guang, Li Yong-Hui   +4 more
core  

Structure-guided discovery of orexin receptor-binding PET ligands

Molecular imaging using positron emission tomography (PET) can serve as a promising tool for visualizing biological targets in the brain. Insights into the expression pattern and the in vivo imaging of the G protein-coupled orexin receptors OX1R and OX2R
Peter, Gmeiner, Jürgen, Einsiedel, Harald, Hübner, Katharina, Distler, Simone, Maschauer, Eduard, Neu, Olaf, Prante   +6 more
core   +1 more source

Hypothalamus-Olfactory System Crosstalk: Orexin A Immunostaining in Mice

, 2017
It is well known that olfaction influences food intake, and conversely, that an individual’s nutritional status modulates olfactory sensitivity. However, what is still poorly understood is the neuronal correlate of this relationship, as well as the ...
López-Mascaraque, Laura, Gascuel, J., Penicaud, Luc, Lemoine, A., Rigault, Caroline, Datiche, F., Benani, A.   +6 more
core   +1 more source

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Neurotrauma Reports
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach, Miranda M. Lim, Akiva S. Cohen   +2 more
doaj   +1 more source