Results 71 to 80 of about 18,205 (239)

Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice

, 2020
Damage to the lateral hypothalamus (LH) causes profound physical inactivity in mammals. Several molecularly distinct types of LH neurons have been identified, including orexin cells and glutamic acid decarboxylase 65 (GAD65) cells, but their interplay in
Christin Kosse (8268174), Edward Bracey (9264803), Denis Burdakov (713787), Cornelia Schöne (8658924)   +3 more
core  

Exogenous Orexin-A Microinjected Into Central Nucleus of the Amygdala Modulates Feeding and Gastric Motility in Rats

Frontiers in Neuroscience, 2020
Orexin-A is a circulating neuropeptide and neurotransmitter that regulates food intake and gastric motility. The central nucleus of the amygdala (CeA), which regulates feeding behavior and gastric function, expresses the orexin-1 receptor.
Tingting Jin, Zhongxin Jiang, Xiao Luan, Zhuling Qu, Feifei Guo, Shengli Gao, Luo Xu, Xiangrong Sun   +7 more
doaj   +1 more source

Respiratory safety of lemborexant in adult and elderly subjects with moderate‐to‐severe chronic obstructive pulmonary disease

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Lemborexant 10 mg, a dual orexin‐receptor antagonist (DORA), did not elicit respiratory depressant effects, as measured by peripheral oxygen saturation (SpO2) or apnea–hypopnea index (AHI), in subjects with moderate‐to‐severe chronic obstructive pulmonary disease (COPD).
Jocelyn Y. Cheng, Daniel Lorch, Nancy Hall, Margaret Moline   +3 more
wiley   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Ken-ichi Yagami, Bernard Bettler, Thomas Kilduff, Satoshi Kunita, Hitomi Takahira, Taizo Matsuki, Mika Nomiyama, Takeshi Sakurai, Noriko Hirashima, Satoru Takahashi, Masashi Yanagisawa   +10 more
core  

Dopaminergic regulation of orexin neurons [PDF]

, 2005
Orexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant-induced locomotor activity.
Meador-Woodruff, James H., Jing, Deqiang, Jackson, Lela L., Deutch, Ariel Y., Bubser, Michael, Fadel, Jim R.   +5 more
core   +1 more source

Overnight Dynamics of Ventricular Cerebrospinal Fluid Amyloid‐Beta, Lactate and Hypocretin in Patients With Hydrocephalus: A Pilot Study

Journal of Sleep Research, EarlyView.
ABSTRACT This pilot observational study evaluated whether frequent overnight sampling of ventricular cerebrospinal fluid could clarify how sleep, hypocretin and lactate relate to amyloid‐β42 dynamics in adults with hydrocephalus. Seven participants underwent hourly ventricular cerebrospinal fluid sampling from early evening to late morning during ...
Casper Schwartz Riedel, Joachim Birch Milan, Niklas Rye Jørgensen, Poul Jennum, Marianne Juhler   +4 more
wiley   +1 more source

Differential roles of orexin receptors in the regulation of sleep/wakefulness

Frontiers in Endocrinology, 2013
Orexin A and orexin B are hypothalamic neuropeptides that play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions such as emotion, reward, and energy homeostasis.
Michihiro eMieda, Natsuko eTsujino, Takeshi eSakurai   +2 more
doaj   +1 more source

Investigation of the “Not Better Explained” Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review

Journal of Sleep Research, EarlyView.
The “Not Better Explained” (NBE) criterion plays a key role in preventing diagnostic misclassification by structuring causal reasoning in sleep medicine. This systematic content analysis compares the use, wording, and excluded conditions of NBE criteria across the ICSD‐3‐TR and DSM‐5‐TR for ten major sleep disorders.
Jean‐Arthur Micoulaud‐Franchi, Vincent P. Martin, Julien Coelho, Régis Lopez, Pierre‐Alexis Geoffroy, Laure Peter‐Derex, Isabelle Lambert, Charles M. Morin, Clélia Quiles, Christophe Gauld   +9 more
wiley   +1 more source

Risks Associated With Benzodiazepine Long‐Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT This systematic literature review evaluated the risks of using benzodiazepine medications for more than 3 months in adults with chronic insomnia. Chronic insomnia is defined as ongoing dissatisfaction with sleep quantity or quality, causing significant distress and impaired functioning during the day.
Dieter Riemann, Chiara Baglioni, Christoph Nissen, Agathe Nevière, Omar Irfan, Pauline Le Nouveau, Chrysoula Leontiou, Damien Léger   +7 more
wiley   +1 more source

Post‐ICU Psychotropic Medication Initiation in Nonagenarian Sepsis Survivors

Journal of the American Geriatrics Society, EarlyView.
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki   +2 more
wiley   +1 more source