Results 91 to 100 of about 20,070 (218)

Does Sleep Curtailment Stimulate Appetite, Motivation to Eat and Dietary Intake in Humans? A Narrative Synthesis of Evidence and Considerations for Future Studies

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Insufficient sleep has been increasingly recognised as a risk factor for obesity, yet the underlying mechanisms remain incompletely understood. Research suggests that sleep restriction promotes excessive dietary intake, and it is commonly assumed that this relationship can be explained by appetite dysregulation.
Sze‐Yen Tan, Isabella Emillya Tjahjono, Ilili Feyesa, Jeew Hettiarachchi, Nahyun Kim, Reagan Pennycuff, Amani Qawasmeh, Robin M. Tucker   +7 more
wiley   +1 more source

Stapled truncated orexin peptides as orexin receptor agonists

Peptides, 2018
The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity.
Karhu, L, Weisell, J, Turunen, PM, Leino, TO, Pätsi, H, Xhaard, H, Kukkonen, JP, Wallén, EAA   +7 more
openaire   +5 more sources

Central orexin A has site-specific effects on luteinizing hormone release in female rats

, 2003
Orexin A stimulates GnRH release from hypothalamic explants in vitro. The sites of action of orexin A in the regulation of LH release have been investigated in vivo in ovariectomized rats that were given vehicle or estradiol benzoate (EB), with or ...
Murray, J.F., Siddiqui, A, Siddiqui, A., Goubillon, M L, Kalamatianos, T, Kennedy, A R, Bloom, S.R., Coen, C W; id_orcid, Young, H., Wilson, C.A., Grimshaw, S.E., Coen, C.W., Bloom, S R, Grimshaw, S E, Murray, J F, Goubillon, M.L., Sivanesan, V, Kennedy, A.R., Small, C.J., Wilson, C A, Young, H, Sivanesan, V., Small, C J, Kalamatianos, T.   +23 more
core   +1 more source

The Effect of Porcine Orexin a on Glucose-Dependent Insulinotropic Polypeptide Plasma Concentrations in Pigs

European Journal of Inflammation, 2010
The orexigenic system was discovered in 1998. It consists of two neuropeptides, Orexin A and Orexin B. Researchers have focused more on Orexin A, since its intracerebroventricular injection into the lateral ventricle of the rat's brain causes an increase
P. Papakonstantinou, N. Tziris, D. Kapoukranidou, A. Gotzamani-Psarrakou, C.H.R. Tsonidis, M.N. Patsikas, G. Papazoglou   +6 more
doaj   +1 more source

Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease

Neurobiology of Disease, 2011
Huntington's disease (HD) is a neurodegenerative disorder involving progressive motor disturbances, cognitive decline, and desynchronized sleep–wake rhythms.
Rhîannan H. Williams, A. Jennifer Morton, Denis Burdakov   +2 more
doaj   +1 more source

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

The Role of Orexin in Stress

, 2010
Orexins (hypocretins) are novel neuropeptides released by some neurons identified in lateral hypothalamus. They are involved in the regulation of energy metabolism, neuroendocrine, sleep and waking.
Han Jin, Sui Nan, Wang Hui-Ying, Wei Chu-Guang, Li Yong-Hui   +4 more
core   +1 more source

Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates Hipp-dependent memory impairment in the A53T mice model of Parkinson’s disease

Molecular Brain, 2019
Parkinson’s disease (PD), classically defined as a progressive motor disorder accompanied with dopaminergic neuron loss and presence of Lewy bodies, is the second most common neurodegenerative disease.
Milos Stanojlovic, Jean Pierre Pallais, Michael K. Lee, Catherine M. Kotz   +3 more
doaj   +1 more source

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin‐1 Levels

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan, Suzan Linssen, Rolf Fronczek, Lucie Barateau, Christelle Peyron, Yves Dauvilliers   +5 more
wiley   +1 more source

Orexin deficiency and narcolepsy [PDF]

, 2013
Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for ...
60251055, 15392, Sakurai, Takeshi
core   +1 more source