Results 91 to 100 of about 18,205 (239)
European Journal of Inflammation, 2010 The orexigenic system was discovered in 1998. It consists of two neuropeptides, Orexin A and Orexin B. Researchers have focused more on Orexin A, since its intracerebroventricular injection into the lateral ventricle of the rat's brain causes an increase
P. Papakonstantinou +6 more
doaj +1 more source
Molecular Brain, 2019 Parkinson’s disease (PD), classically defined as a progressive motor disorder accompanied with dopaminergic neuron loss and presence of Lewy bodies, is the second most common neurodegenerative disease.
Milos Stanojlovic +3 more
doaj +1 more source
Stress, stress systems, and Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly +5 more
wiley +1 more source
El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]
, 2007 [spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
core
, 2011 Orexin (also known as hypocretin) neurons play a key role in regulating sleep-wake behavior, but the links between orexin neuron electrophysiology and function have not been explored.
Katherine S. Williams +1 more
core +1 more source
The role of orexin A in the pathogenesis of ischaemic stroke at high altitude
Experimental PhysiologyOrexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression. This study aimed to investigate the effect of high altitude on orexin expression and its pathophysiological ...
Minxia Zhu +7 more
doaj +1 more source
Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea
Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 100-112, June 2026.Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy +3 more
wiley +1 more source
, 2016 (a) Individual patient CSF orexin levels at baseline and then 8 days into dexamethasone (DEX) therapy for ALL. Mean baseline orexin concentration is equivalent to mean DEX day 8 orexin concentration.
Linda C. Stork (3595220) +5 more
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Orexin System: The Key for a Healthy Life
Frontiers in Physiology, 2017 The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive a variety of signals related to environmental, physiological and emotional
Sergio Chieffi +22 more
doaj +1 more source
Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease
Neurobiology of Disease, 2011 Huntington's disease (HD) is a neurodegenerative disorder involving progressive motor disturbances, cognitive decline, and desynchronized sleep–wake rhythms.
Rhîannan H. Williams +2 more
doaj +1 more source