Results 101 to 110 of about 18,205 (239)

Stapled truncated orexin peptides as orexin receptor agonists

Peptides, 2018
The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity.
Karhu, L, Weisell, J, Turunen, PM, Leino, TO, Pätsi, H, Xhaard, H, Kukkonen, JP, Wallén, EAA   +7 more
openaire   +5 more sources

Gallic Acid‐Mediated Enhancement of Diazepam‐Induced Sedation via GABAA Receptor Modulation: In Vivo and In Silico Evaluation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Noshin Tasnim Yana, Anike Chakrabarty, Chinmoy Kumar Saha, Nikhat Jamal Siddiqi, Norah Alnazhan, Md. Sakib Al Hasan, Feroz Khan Nun, Imam Hossen Rakib, Md. Nasimul Haque Shipon, Emon Mia, Md Asaduzzaman Jony, Ali Mohamod Wasaf Hasan, Muhammad Torequl Islam, Azmat Ali Khan   +13 more
wiley   +1 more source

Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in IP rats

, 2016
Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in IP ...
SYS Khoo (15829220), Jee Hyun Kim (13075509), RM Brown (14449740), B Jupp (13478248), AK Kim (15829217), AJ Lawrence (5578280)   +5 more
core  

Narcolepsy with resolution of cataplexy and persisting orexin deficiency.

, 2020
None Narcolepsy type 1 is a debilitating chronic neurological disorder, whose main symptoms of excessive daytime sleepiness and cataplexy may partially improve with time, but typically do not fully resolve.
Wasserman, Danielle, Rosenzweig, Ivana, Bassetti, Claudio L. A.   +2 more
core   +1 more source

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Scientific Reports
Tunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (ATR).
Maiju K. Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M. Riddy, Christopher J. Langmead, Jyrki P. Kukkonen, Henri Xhaard   +7 more
doaj   +1 more source

A comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodents

Behavioral and Brain Functions, 2007
Background The orexins (hypocretins) are a family of peptides found primarily in neurons in the lateral hypothalamus. Although the orexinergic system is generally thought to be the same across species, the orexins are involved in behaviors which show ...
Nixon Joshua P, Smale Laura
doaj   +1 more source

Orexin deficiency and narcolepsy

, 2013
Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for ...
60251055, 15392, Sakurai, Takeshi
core   +1 more source

Orexin A Differentially Influences the Extinction Retention of Recent and Remote Fear Memory

Frontiers in Neuroscience, 2018
Recently the role of the orexin system in the learning and memory, especially orexin A, which could enhance fear memory through regulating the activity of amygdala, has drawn considerable attention.
Le Shi, Le Shi, Wenhao Chen, Jiahui Deng, Sijing Chen, Ying Han, Muhammad Z. Khan, Muhammad Z. Khan, Jiajia Liu, Jiajia Liu, Jianyu Que, Yanping Bao, Lin Lu, Lin Lu, Lin Lu, Jie Shi   +15 more
doaj   +1 more source

An electrophysiological study of Orexin A and [Ala11, D-Leu15] orexin-B effects in rat periaqueductal gray slices

, 2007
Orexins，又稱做hypocretins，是在1998年所發現的神經胜肽，有兩個成員，orexin A( hypocretin 1 )及orexin B( hypocretin 2 )。Orexin A是由33個胺基酸所組成，並且有兩個雙硫鍵，而orexin B則是28個胺基酸所組成；orexin A及orexin B的胺基酸序列的同源相似性為46%。 Orexin受體屬於G蛋白偶合受體( G-protein coupled receptor )，有兩種亞型，分別是OX1R及OX2R ...
Fu, Szu-Ying, 傅思穎
core  

Excessive daytime sleepiness and frequent nightmares are associated with suicidal ideation among psychiatric inpatients

Sleep Research, Volume 3, Issue 2, Page 161-169, June 2026.
Abstract Objectives This study aimed to explore the association between excessive daytime sleepiness (EDS) and frequent nightmares and the risk for suicidal ideation (SI) among psychiatric inpatients. Methods In this cross‐sectional study, 650 inpatients were consecutively recruited from the inpatient department of Shantou University Mental Health ...
Pikun Tan, Jun Wu, Yanyuan Dai, Le Chen, Jiansheng Zhang, Ruifan Shao, Chongtao Xu, Baixin Chen, Yun Li   +8 more
wiley   +1 more source