Results 101 to 110 of about 20,070 (218)

Structure-guided discovery of orexin receptor-binding PET ligands [PDF]

Molecular imaging using positron emission tomography (PET) can serve as a promising tool for visualizing biological targets in the brain. Insights into the expression pattern and the in vivo imaging of the G protein-coupled orexin receptors OX1R and OX2R
Peter, Gmeiner, Jürgen, Einsiedel, Harald, Hübner, Katharina, Distler, Simone, Maschauer, Eduard, Neu, Olaf, Prante   +6 more
core   +2 more sources

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Scientific Reports
Tunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (ATR).
Maiju K. Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M. Riddy, Christopher J. Langmead, Jyrki P. Kukkonen, Henri Xhaard   +7 more
doaj   +1 more source

Orexin A attenuates unconditioned sexual motivation in male rats

, 2009
Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation.
Bai, Y. J., Sui, N., Han, J., Li, Y. H., N. Sui, Yang, X. Y., Zheng, X. G.   +6 more
core   +1 more source

Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in IP rats

, 2016
Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in IP ...
SYS Khoo (15829220), Jee Hyun Kim (13075509), RM Brown (14449740), B Jupp (13478248), AK Kim (15829217), AJ Lawrence (5578280)   +5 more
core  

Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

, 2016
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 ...
Annette G. Beck-Sickinger (92957), Richard M. Söll (2724037), Manja Lang (2141818), Frank M. Dautzenberg (2724040), Franz Dürrenberger (2724043)   +4 more
core   +1 more source

An electrophysiological study of Orexin A and [Ala11, D-Leu15] orexin-B effects in rat periaqueductal gray slices

, 2007
Orexins，又稱做hypocretins，是在1998年所發現的神經胜肽，有兩個成員，orexin A( hypocretin 1 )及orexin B( hypocretin 2 )。Orexin A是由33個胺基酸所組成，並且有兩個雙硫鍵，而orexin B則是28個胺基酸所組成；orexin A及orexin B的胺基酸序列的同源相似性為46%。 Orexin受體屬於G蛋白偶合受體( G-protein coupled receptor )，有兩種亞型，分別是OX1R及OX2R ...
Fu, Szu-Ying, 傅思穎
core  

Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina

, 2017
PURPOSE: Orexin-A, -B play a crucial role in arousal and feeding by activating two G-protein-coupled receptors: OX1R and OX2R. Orexins and orexin receptors are expressed in retinal neurons.
Gong Zhang, Shi-Jun Weng, Xiao-Hua Wu, Guo-Zhong Xu,, Yong-Mei Zhong, Xiong-Li Yang   +5 more
core   +1 more source

Research progress of narcolepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine. Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal.
Fu-long XIAO, Jun ZHANG, Fang HAN
doaj  

Dynamic Interactions between Orexin and Dynorphin May Delay Onset of Functional Orexin Effects: A Modeling Study

, 2011
Orexin (also known as hypocretin) neurons play a key role in regulating sleep-wake behavior, but the links between orexin neuron electrophysiology and function have not been explored.
Katherine S. Williams, Cecilia G. Diniz Behn   +1 more
core   +1 more source

Relationship Between Cognitive Impairments and Serum Orexin Levels in Epilepsy Patients

Archives of Epilepsy
Objective: Recent studies on neurodegenerative diseases have indicated that Orexin A plays a role in cognitive impairment. Furthermore, animal studies have demonstrated that Orexin A enhances synaptic plasticity in the hippocampus.
Zeliha Yücel, İrem Fatma Uludağ, Ufuk Şener, Alp Sarıteke, Anıl Baysoy   +4 more
doaj   +1 more source