Results 81 to 90 of about 18,205 (239)

Lights On or Off? The Efficacy of Light Therapy as Add‐On to Cognitive Behavioural Therapy for Insomnia—A Pilot Study

Journal of Sleep Research, EarlyView.
ABSTRACT Cognitive behavioural therapy for insomnia (CBT‐I) is recommended as first‐line treatment for insomnia disorder. However, around 25% of the patients do not respond to the treatment, and only 40% achieve full remission. The current study investigates the therapeutic potential of light therapy as an add‐on to CBT‐I.
Sarah R. Schmid, Christine Blume, Johanna Ell, Nikolas Konzen, Matthias Apweiler, Bernd Feige, Bernd L. Fiebich, Julian E. Schiel, Katharina Domschke, Kai Spiegelhalder   +9 more
wiley   +1 more source

Does Sleep Curtailment Stimulate Appetite, Motivation to Eat and Dietary Intake in Humans? A Narrative Synthesis of Evidence and Considerations for Future Studies

Journal of Sleep Research, EarlyView.
ABSTRACT Insufficient sleep has been increasingly recognised as a risk factor for obesity, yet the underlying mechanisms remain incompletely understood. Research suggests that sleep restriction promotes excessive dietary intake, and it is commonly assumed that this relationship can be explained by appetite dysregulation.
Sze‐Yen Tan, Isabella Emillya Tjahjono, Ilili Feyesa, Jeew Hettiarachchi, Nahyun Kim, Reagan Pennycuff, Amani Qawasmeh, Robin M. Tucker   +7 more
wiley   +1 more source

Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

, 2016
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 ...
Annette G. Beck-Sickinger (92957), Richard M. Söll (2724037), Manja Lang (2141818), Frank M. Dautzenberg (2724040), Franz Dürrenberger (2724043)   +4 more
core   +1 more source

Associations of Cerebrospinal Fluid Orexin‐A, Alzheimer Disease Biomarkers, and Cognitive Performance

Annals of Clinical and Translational Neurology
Objective Cerebrospinal fluid (CSF) orexin‐A has been suggested to be a biomarker of Alzheimer disease (AD). In both cognitively unimpaired healthy older adults and individuals with symptomatic AD, CSF orexin‐A is positively associated with CSF Aβ42, p ...
Ruijin Lu, Krish Shah, Cristina D. Toedebusch, Ashley Hess, Rachel Richardson, Emmanuel Mignot, Suzanne E. Schindler, Tammie L. S. Benzinger, Shaney Flores, Jason Hassenstab, Chengjie Xiong, John C. Morris, David M. Holtzman, Brendan P. Lucey   +13 more
doaj   +1 more source

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Orexin-A and Orexin-B During the Postnatal Development of the Rat Brain [PDF]

, 2009
Orexin-A and orexin-B are hypothalamic neuropeptides isolated from a small group of neurons in the hypothalamus, which project their axons to all major parts of the central nervous system.
Joost le Feber, Irina I. Stoyanova, Wim L. C. Rutten, Rutten, Wim, le Feber, Jakob, Stoyanova, Irina   +5 more
core   +1 more source

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

The Journal of Physiology, EarlyView.
Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg, Pieter Nicolaas de Greef, Huibert D. Mansvelder, Mahesh Miikael Karnani   +3 more
wiley   +1 more source

Orexin receptors in GtoPdb v.2023.1

, 2023
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [43]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor ...
de Lecea, Luis, Jacobson, Laura, Hartman, Debbie, Sakurai, Takeshi, Upton, Neil, Hoyer, Daniel, Renger, John, Winrow, Christopher J., Yanagisawa, Masashi, Porter, Rod, Kilduff, Thomas, Kukkonen, Jyrki P., Siegel, Jerome M, Bonaventure, Pascal, Coleman, Paul, Sutcliffe, Gregor, McDonald, Terrence P., Aston-Jones, Gary   +17 more
core   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Neurotrauma Reports
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach, Miranda M. Lim, Akiva S. Cohen   +2 more
doaj   +1 more source