Results 111 to 120 of about 29,596 (259)

Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. [PDF]

, 2014
Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning.
Longordo, F., Lüthi, A., Massonnet, C., Perin, M., Welker, E.   +4 more
core   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

Orexin System: The Key for a Healthy Life

Frontiers in Physiology, 2017
The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive a variety of signals related to environmental, physiological and emotional
Sergio Chieffi, Marco Carotenuto, Vincenzo Monda, Anna Valenzano, Ines Villano, Francesco Precenzano, Domenico Tafuri, Monica Salerno, Nicola Filippi, Francesco Nuccio, Maria Ruberto, Vincenzo De Luca, Luigi Cipolloni, Giuseppe Cibelli, Maria P. Mollica, Diego Iacono, Diego Iacono, Diego Iacono, Ersilia Nigro, Marcellino Monda, Giovanni Messina, Giovanni Messina, Antonietta Messina   +22 more
doaj   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individuals

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1473-1486, May 2026.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Orexin A Differentially Influences the Extinction Retention of Recent and Remote Fear Memory

Frontiers in Neuroscience, 2018
Recently the role of the orexin system in the learning and memory, especially orexin A, which could enhance fear memory through regulating the activity of amygdala, has drawn considerable attention.
Le Shi, Le Shi, Wenhao Chen, Jiahui Deng, Sijing Chen, Ying Han, Muhammad Z. Khan, Muhammad Z. Khan, Jiajia Liu, Jiajia Liu, Jianyu Que, Yanping Bao, Lin Lu, Lin Lu, Lin Lu, Jie Shi   +15 more
doaj   +1 more source

Prawn Shell Chitosan Has Anti-Obesogenic Properties, Influencing Both Nutrient Digestibility and Microbial Populations in a Pig Model [PDF]

, 2015
This study was supported financially (Grant-Aid Agreement No. MFFRI/07/01) under the Sea Change Strategy with the support of the Marine Institute and the Department of Agriculture, Food and the Marine, funded under the National Development Plan 2007 ...
Egan, Aine M., Hayes, Maria, O'Doherty, John V., Sweeney, Torres   +3 more
core   +1 more source

Effectiveness of Melatonin‐Containing Foods on Promoting Sleep: A Scoping Review

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Effectiveness of melatonin‐containing foods promoting sleep: A scoping review. ABSTRACT Melatonin plays a crucial role in managing the body's sleep–wake cycle, and its natural occurrence in certain foods has generated interest in dietary interventions to improve sleep.
Tanzeela Nisar, Andrea Fuller, Prajwal Gyawali, Stephen Bird   +3 more
wiley   +1 more source

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Neurotrauma Reports
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach, Miranda M. Lim, Akiva S. Cohen   +2 more
doaj   +1 more source

A comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodents

Behavioral and Brain Functions, 2007
Background The orexins (hypocretins) are a family of peptides found primarily in neurons in the lateral hypothalamus. Although the orexinergic system is generally thought to be the same across species, the orexins are involved in behaviors which show ...
Nixon Joshua P, Smale Laura
doaj   +1 more source

Diversity and noise effects in a model of homeostatic regulation of the sleep-wake cycle [PDF]

, 2012
Recent advances in sleep neurobiology have allowed development of physiologically based mathematical models of sleep regulation that account for the neuronal dynamics responsible for the regulation of sleep-wake cycles and allow detailed examination of ...
Braun, Hans A., Hernández-García, Emilio, Patriarca, Marco, Postnova, Svetlana, Toral, Raúl   +4 more
core   +4 more sources