Results 111 to 120 of about 18,205 (239)
Orexin A attenuates unconditioned sexual motivation in male rats
, 2009 Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation.
Bai, Y. J. +6 more
core
Structure-guided discovery of orexin receptor-binding PET ligands
Molecular imaging using positron emission tomography (PET) can serve as a promising tool for visualizing biological targets in the brain. Insights into the expression pattern and the in vivo imaging of the G protein-coupled orexin receptors OX1R and OX2R
Peter, Gmeiner +6 more
core +1 more source
, 2012 Orexin peptides regulate locomotor activity and sleep-wake balance by activating orexin 1 and orexin 2 receptors (OX1R and OX2R). Dual OX1R and OX2R antagonists reduce activity and promote sleep in multiple species, including man.
Mang, Geraldine +8 more
core +1 more source
Orexin and Alzheimer’s Disease
, 2016 Alzheimer's disease (AD) is the most frequent age-related dementia. It prevalently causes cognitive decline, although it is frequently associated with secondary behavioral disturbances. AD neurodegeneration characteristically produces a remarkable destruction of the sleep-wake cycle, with diurnal napping, nighttime arousals, sleep fragmentation, and ...
openaire +3 more sources
Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik +44 more
wiley +1 more source
, 2010 Orexins (hypocretins) are novel neuropeptides released by some neurons identified in lateral hypothalamus. They are involved in the regulation of energy metabolism, neuroendocrine, sleep and waking.
Han Jin +4 more
core
European Journal of Neurology, Volume 33, Issue 6, June 2026.This graphical abstract presents the review process (including 41 studies). It highlights the use of machine learning techniques in adults with CDH, such as unsupervised learning for phenotype discovery and supervised learning for diagnosis classification. The figure summarizes the strengths and limitations of each approach, along with key clinical and
Annina Helmy +8 more
wiley +1 more source
Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1841-1844, June 2026.Cannabis use in older adults may have a broad range of effects in older adults impacting Mind, Mobility, Medications, Multi‐complexity, and what Matters Most.
Erik Fraunberger, Maia von Maltzahn
wiley +1 more source
Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina
, 2017 PURPOSE: Orexin-A, -B play a crucial role in arousal and feeding by activating two G-protein-coupled receptors: OX1R and OX2R. Orexins and orexin receptors are expressed in retinal neurons.
Gong Zhang +5 more
core
Journal of Sleep Research, Volume 35, Issue 3, June 2026.How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads +8 more
wiley +1 more source