Results 131 to 140 of about 18,205 (239)

Orexin receptors in GtoPdb v.2025.3

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [79]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, prepro-
de Lecea, Luis, Sakurai, Takeshi, Hartman, Debbie, Upton, Neil, Winrow, Christopher J., Renger, John, Hoyer, Daniel, Yanagisawa, Masashi, Porter, Rod, Kilduff, Thomas, Kukkonen, Jyrki P., Siegel, Jerome M, Sutcliffe, J. Gregor, Coleman, Paul, Bonaventure, Pascal, McDonald, Terrence P., Aston-Jones, Gary, Jacobson, Laura H.   +17 more
core   +1 more source

Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus

, 2010
The paraventricular nucleus of the midline thalamus (PVT) innervates areas of the extended amygdala known to play a key role in the expression of emotional behaviors.
Li, Sa, Wei, Chuguang, Sui, Nan, Kirouac, Gilbert J., Wang, Huiying, Li, Yonghui, Gilbert J. Kirouac   +6 more
core  

Detection of reduced orexin-A/hypocretin-1 and its fragments by orexin-A “gold-standard” radioimmunoassay

Background: Orexin-A/hypocretin-1 level is determined in the cerebrospinal fluid samples as a part of clinical narcolepsy diagnostics utilizing a specific commercial radioimmunoassay (RIA); this assay is also widely used in research of many other ...
Kukkonen, Jyrki P., Turunen, Pauli M., Rinne, Maiju K.   +2 more
core   +1 more source

Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference

, 2013
Orexins are found to participate in mediating stress-induced drug relapse. However, the neuroanatomical basis that orexin transmission modulates stress induced drug seeking remains unknown.
Wei, Chuguang, Sui, Nan, Li, YH (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China., Qi, Keke, Li, Yonghui   +4 more
core  

Orexinergic Dysregulation in Major Depressive Disorder: Insights from a Prospective Cohort Study Evaluating MADRS, PSQI, and MoCA Scores. [PDF]

Indian J Psychol Med
Viswanathan V, Sood M, Pandey S, Reeta Kh.   +3 more
europepmc   +1 more source

Novel 3‑Heteroaryl Pyrrolidine and Piperidine Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia. [PDF]

ACS Med Chem Lett
Sabnis RW.
europepmc   +1 more source

Signaling via Orexin Receptors : A Pharmacological Study

, 2004
The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation
Holmqvist, Tomas
core  

Physiological significance of autocrine orexinergic signaling in extra-hypothalamic tissues. [PDF]

Physiol Rep
Hakizimana JC, Olubiyi MV, Alagbonsi AI.
europepmc   +1 more source

Orexin deficiency and narcolepsy

Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for ...
Sakurai, Takeshi
core  

Orexins, Psychosis, and Antipsychotics: A Systematic Review of Studies of Orexin Levels and the Effects of Dual Orexin Receptor Antagonists (DORAs). [PDF]

Brain Sci
Margoni S, Hasaj S, Donofrio G, Kotzalidis GD, Callovini T, Pinto M, Scialpi C, Bucci M, Anesini MB, Sani G, Moccia L, Janiri D.   +11 more
europepmc   +1 more source