Results 121 to 130 of about 29,596 (259)

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source

Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity [PDF]

, 2017
Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties.
af Gennas, Gustav Boije, Kukkonen, Jyrki P., Lindholm, Dan, Rinne, Maiju K., Turku, Ainoleena, Xhaard, Henri   +5 more
core   +2 more sources

Research progress of narcolepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine. Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal.
Fu-long XIAO, Jun ZHANG, Fang HAN
doaj  

Night‐to‐night rapid eye movement sleep variability: A relevant marker of early amyloid‐β deposition

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep disturbances are prevalent in patients with Alzheimer's disease (AD) and may emerge before overt clinical symptoms. We characterized sleep alterations in cognitively unimpaired older adults with cerebral amyloid deposition, and assessed their associations with regional amyloid deposition and cognitive and psychoaffective ...
Blandine Montagne, Maéva Boulin, Anaïs Hamel, Pierre Champetier, Stéphane Rehel, Florence Mézenge, Brigitte Landeau, Marion Delarue, Oriane Hébert, Célia Soussi, Françoise Bertran, Gaël Chételat, Claire André, Géraldine Rauchs, the Medit‐Ageing Research Group   +14 more
wiley   +1 more source

Dynamic Brain State Alterations in Narcolepsy: A Hidden Markov Model Approach to Thalamocortical Instability and Symptom‐Specific Neural Correlates

Brain and Behavior, Volume 16, Issue 4, April 2026.
This graphical abstract illustrates how Hidden Markov modeling of functional magnetic resonance imaging (fMRI) reveals five dynamic brain states in narcolepsy type 1 (NT1), with reduced thalamocortical arousal (State 1) and elevated REM‐like limbic‐motor (State 4) and reward‐introspection (State 5) states linking to hallucinations and daytime ...
Wenyi Li, Lijing Jia, Xingyu Wang, Yuanhui Zhao, Zhenzhong Li, Zuojun Geng   +5 more
wiley   +1 more source

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Scientific Reports
Tunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (ATR).
Maiju K. Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M. Riddy, Christopher J. Langmead, Jyrki P. Kukkonen, Henri Xhaard   +7 more
doaj   +1 more source

Global and Regional Vigilance: Are There Two Types of Local Sleep?

Brain and Behavior, Volume 16, Issue 4, April 2026.
The term local sleep as it is used in the literature is confusing and probably consists of two types of brain states. The first one originates from increased activity in certain cortical areas during waking, resulting in increased activity in the slow‐waves range in that same area during subsequent NREM sleep. The second one consists of local states in
Tom Deboer
wiley   +1 more source

Sleep‐Dependent Clearance of Brain Metabolites via the Glymphatic System: Implications for Alzheimer's Pathophysiology

Brain and Behavior, Volume 16, Issue 4, April 2026.
Slow‐wave sleep promotes glymphatic transport through coordinated norepinephrine dynamics, vasomotion, and polarized AQP4‐dependent fluid exchange, thereby facilitating clearance of amyloid‐beta and tau. In contrast, sleep disruption, aging, vascular dysfunction, and AQP4 abnormalities impair this system and may accelerate Alzheimer‐related pathology ...
Farshad Zare, Gulnora Shakhmurova, Jasur Rizaev, Aseel Smerat, Rosull Saadoon Abbood, Vinay Patil, Manoj Kumar‐Mishra   +6 more
wiley   +1 more source

ラット脳室内へのオレキシン-A持続投与は明期の摂食量を増加させたが、体重増加には影響はなかった [PDF]

, 2000
Orexins(orexin-A and -B)are recently identified neuropeptides,which are thought to be implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist,BIBO3304,to examine whether NPY is involved in orexin-induced feeding ...
Yamanaka Akihiro, 山中 章弘
core  

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source