Results 21 to 30 of about 18,205 (239)

Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson's disease: A retrospective study.

PLoS ONE, 2022
Patients with Parkinson's disease (PD) often suffer from sleep disturbances, including excessive daytime sleepiness (EDS) and rapid eye movement sleep behavior disorder (RBD).
Takuya Ogawa, Yuta Kajiyama, Hideaki Ishido, Shigeru Chiba, Gajanan S Revankar, Tomohito Nakano, Seira Taniguchi, Takashi Kanbayashi, Kensuke Ikenaka, Hideki Mochizuki   +9 more
doaj   +1 more source

Orexin-a elevation in antipsychotic-treated compared to drug-free patients with schizophrenia: A medication effect independent of metabolic syndrome

Journal of the Formosan Medical Association, 2022
Background/Purpose: Orexin-A levels are reportedly increased in antipsychotic (APD)-treated patients with schizophrenia compared to healthy controls and have been associated with metabolic abnormalities.
Po-Yu Chen, Chin-Kuo Chang, Chun-Hsin Chen, Su-Chen Fang, Valeria Mondelli, Chih-Chiang Chiu, Mong-Liang Lu, Ling-Ling Hwang, Ming-Chyi Huang   +8 more
doaj   +1 more source

Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. [PDF]

PLoS ONE, 2013
Both orexin and neurotensin are expressed in the lateral hypothalamic area (LHA) and have been implicated in the regulation of feeding, motor activity and the reward system.
Naoki Furutani, Mari Hondo, Haruaki Kageyama, Natsuko Tsujino, Michihiro Mieda, Masashi Yanagisawa, Seiji Shioda, Takeshi Sakurai   +7 more
doaj   +1 more source

Orexin Signaling: A Complex, Multifaceted Process

Frontiers in Cellular Neuroscience, 2022
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B).
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Daniel Hoyer, Daniel Hoyer, Daniel Hoyer, Laura H. Jacobson, Laura H. Jacobson, Laura H. Jacobson, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone   +16 more
doaj   +1 more source

Integrative Physiology of Orexins and Orexin Receptors

CNS & Neurological Disorders - Drug Targets, 2009
Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
Michihiro, Mieda, Takeshi, Sakurai
openaire   +2 more sources

In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B

, 2023
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are currently being developed to treat insomnia and narcolepsy.
Rosalba, Sortino, Diane, Nepomuceno, Ernest, Giralt, Alexandre, Gomila-Juaneda, Pascal, Bonaventure, Davia, Prischich, Carlo, Matera, Pau, Gorostiza, Salvador, Guardiola, Luis, de Lecea, Monica, Varese   +10 more
core   +1 more source

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.

PLoS ONE, 2022
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy.
Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa   +12 more
doaj   +1 more source

Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review

Brain Circulation, 2020
Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex concerned in the wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin.
Hayder M Al-Kuraishy, May H Abdulhadi, Nawar R Hussien, Marwa S Al-Niemi, Huda A Rasheed, Ali I Al-Gareeb   +5 more
doaj   +1 more source

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
Herczeg, László, László Herczeg, Csilla S Molnár, Péter Gergely, Hrabovszky Erik, Borsay, Beáta Á., Hrabovszky, Erik, Liposits, Zsolt, Erik Hrabovszky, Gergely Péter, Borsay Beáta Á., Gergely, Péter, Liposits Zsolt, Molnár, Csilla S., Zsolt Liposits, Molnár Csilla S., Beáta Á Borsay, Herczeg László   +17 more
core   +1 more source

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinans bearing multiple effective residues (TriMER) library

, 2021
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors.
Jumpei, Horiuchi, Yasuyuki, Nagumo, Ryuichiro, Oshita, Hiroaki, Gouda, Yukiko, Ishikawa, Yasuo, Uchida, Tetsu, Sato, Hiroshi, Nagase, Tsuyoshi , Saitoh, Akihisa, Tokuda, Takeshi, Sakurai, Noriki, Kutsumura, Masashi, Yanagisawa, Mao, Amezawa, Yasuhiro, Ogawa, Naoshi, Yamamoto, Ryuji, Tanimura, Emi, Hasegawa, Yoko, Irukayama-Tomobe   +18 more
core   +1 more source