Results 21 to 30 of about 20,070 (218)

Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice

Frontiers in Neuroscience, 2021
The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of histamine neurons is increased in patients with NT1, results on orexin-deficient mouse models ...
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Cristiano Bombardi, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli   +9 more
doaj   +1 more source

El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]

, 2007
[spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
core   +6 more sources

Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson's disease: A retrospective study.

PLoS ONE, 2022
Patients with Parkinson's disease (PD) often suffer from sleep disturbances, including excessive daytime sleepiness (EDS) and rapid eye movement sleep behavior disorder (RBD).
Takuya Ogawa, Yuta Kajiyama, Hideaki Ishido, Shigeru Chiba, Gajanan S Revankar, Tomohito Nakano, Seira Taniguchi, Takashi Kanbayashi, Kensuke Ikenaka, Hideki Mochizuki   +9 more
doaj   +1 more source

Orexin Signaling: A Complex, Multifaceted Process

Frontiers in Cellular Neuroscience, 2022
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B).
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Daniel Hoyer, Daniel Hoyer, Daniel Hoyer, Laura H. Jacobson, Laura H. Jacobson, Laura H. Jacobson, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone   +16 more
doaj   +1 more source

Integrative Physiology of Orexins and Orexin Receptors

CNS & Neurological Disorders - Drug Targets, 2009
Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
Michihiro, Mieda, Takeshi, Sakurai
openaire   +3 more sources

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinans bearing multiple effective residues (TriMER) library [PDF]

, 2021
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors.
Jumpei, Horiuchi, Yasuyuki, Nagumo, Ryuichiro, Oshita, Hiroaki, Gouda, Yukiko, Ishikawa, Yasuo, Uchida, Tetsu, Sato, Hiroshi, Nagase, Tsuyoshi , Saitoh, Akihisa, Tokuda, Takeshi, Sakurai, Noriki, Kutsumura, Masashi, Yanagisawa, Mao, Amezawa, Yasuhiro, Ogawa, Naoshi, Yamamoto, Ryuji, Tanimura, Emi, Hasegawa, Yoko, Irukayama-Tomobe   +18 more
core   +2 more sources

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
Herczeg, László, Molnár, Csilla S., Borsay, Beáta Á., Hrabovszky, Erik, Liposits, Zsolt, Gergely, Péter   +5 more
core   +3 more sources

Orexin, cardio-respiratory function and hypertension

Frontiers in Neuroscience, 2014
In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. 1) Orexin, cardiovascular function and hypertension.
Aihua eLi, Eugene E Nattie
doaj   +1 more source

Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review

Brain Circulation, 2020
Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex concerned in the wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin.
Hayder M Al-Kuraishy, May H Abdulhadi, Nawar R Hussien, Marwa S Al-Niemi, Huda A Rasheed, Ali I Al-Gareeb   +5 more
doaj   +1 more source

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.

PLoS ONE, 2022
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy.
Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa   +12 more
doaj   +1 more source