Results 21 to 30 of about 29,596 (259)
Integrative Physiology of Orexins and Orexin Receptors
CNS & Neurological Disorders - Drug Targets, 2009 Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
Michihiro, Mieda, Takeshi, Sakurai
openaire +2 more sources
Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model [PDF]
, 2014 Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity andseveral eating disorders. Currently, little is known about the neuronal circuitries activated by the acute ingestion of arewarding ...
Patrone, Anabela +3 more
core +2 more sources
Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review
Brain Circulation, 2020 Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex concerned in the wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin.
Hayder M Al-Kuraishy +5 more
doaj +1 more source
PLoS ONE, 2022 Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy.
Hikari Yamamoto +12 more
doaj +1 more source
Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]
, 2012 Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D +3 more
core +3 more sources
Orexin, cardio-respiratory function and hypertension
Frontiers in Neuroscience, 2014 In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. 1) Orexin, cardiovascular function and hypertension.
Aihua eLi, Eugene E Nattie
doaj +1 more source
The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. [PDF]
, 2014 The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM.
Kilduff, Thomas S +4 more
core +2 more sources
European Journal of Histochemistry, 2009 The presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques.
C Dall’Aglio +6 more
doaj +1 more source
Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. [PDF]
, 2017 BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ...
Ceesay, Paulette +9 more
core +1 more source
Orphanet Journal of Rare Diseases, 2020 Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi +13 more
doaj +1 more source