Results 11 to 20 of about 18,205 (239)
Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone
Brain Sciences, 2022 Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2).
Martin A. Katzman, Matthew P. Katzman
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Activity of putative orexin neurons during cataplexy
Molecular Brain, 2022 It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou +7 more
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Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors. [PDF]
Acta Crystallogr F Struct Biol CommunThe crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Mima M +4 more
europepmc +2 more sources
Frontiers in Neuroendocrinology, 2018 The neuropeptides orexins are important in regulating the neurobiological systems that respond to stressful stimuli. Furthermore, orexins are known to play a role many of the phenotypes associated with stress-related mental illness such as changes in cognition, sleep-wake states, and appetite.
Laura A, Grafe, Seema, Bhatnagar
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Context-Dependent Temporal Changes in Hypnotics Involved in Suicide Attempts. [PDF]
Neuropsychopharmacol RepTemporal changes in hypnotics involved in suicide attempts showed context‐dependent shifts. Dual orexin receptor antagonists increased significantly, while benzodiazepine involvement declined only in overdose‐related attempts. Melatonin receptor agonists showed no significant trend during 2020.
Sasaki T +5 more
europepmc +2 more sources
Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension
Scientific Reports, 2021 Brain orexin system hyperactivity contributes to neurogenic hypertension. We previously reported upregulated neuronal kinin B1 receptor (B1R) expression in hypertension.
Rohan Umesh Parekh +6 more
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The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). [PDF]
PLoS ONE, 2014 This study provides a general approach to the presence and possible role of orexins and their receptors in the gut (three gastric chambers and intestine) of confined environment bottlenose dolphin.
Claudia Gatta +9 more
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Aquaculture Reports, 2020 Orexins are neuropeptides involved in energy homeostasis. In fish, the function of orexin-A in glucose metabolism is less reported. The present study aims to identify the potential role of orexin-A in the glucose absorption and metabolism in common carp.
Liping Yang +8 more
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Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling. [PDF]
PLoS ONE, 2016 Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL). Sleep disturbance can negatively impact overall quality of life,
David E Kram +5 more
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Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice
Frontiers in Neuroscience, 2021 The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of histamine neurons is increased in patients with NT1, results on orexin-deficient mouse models ...
Chiara Berteotti +9 more
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