Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice [PDF]
eLife, 2019 Uninterrupted arousal is important for survival during threatening situations. Activation of orexin/hypocretin neurons is implicated in sustained arousal.
Srikanta Chowdhury +10 more
doaj +2 more sources
Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B [PDF]
Journal of Endocrinology, 2006 Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides;
J E, Digby +5 more
openaire +3 more sources
The novel role of the neuropeptides Orexin and QRFP and their involvement in Alzheimer's disease [PDF]
, 2014 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University London.Alzheimer’s disease (AD) is a neurodegenerative disease which affects over 500,000 people in the UK.
Davies, Julie
core +7 more sources
Evolution of Orexin Neuropeptide System: Structure and Function
Frontiers in Neuroscience, 2020 Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya, Takeshi Sakurai
doaj +1 more source
The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). [PDF]
PLoS ONE, 2014 This study provides a general approach to the presence and possible role of orexins and their receptors in the gut (three gastric chambers and intestine) of confined environment bottlenose dolphin.
Claudia Gatta +9 more
doaj +1 more source
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B [PDF]
, 2023 Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are currently being developed to treat insomnia and narcolepsy.
Rosalba, Sortino +10 more
core +2 more sources
Aquaculture Reports, 2020 Orexins are neuropeptides involved in energy homeostasis. In fish, the function of orexin-A in glucose metabolism is less reported. The present study aims to identify the potential role of orexin-A in the glucose absorption and metabolism in common carp.
Liping Yang +8 more
doaj +1 more source
Journal of the Formosan Medical Association, 2022 Background/Purpose: Orexin-A levels are reportedly increased in antipsychotic (APD)-treated patients with schizophrenia compared to healthy controls and have been associated with metabolic abnormalities.
Po-Yu Chen +8 more
doaj +1 more source
Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling. [PDF]
PLoS ONE, 2016 Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL). Sleep disturbance can negatively impact overall quality of life,
David E Kram +5 more
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Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. [PDF]
PLoS ONE, 2013 Both orexin and neurotensin are expressed in the lateral hypothalamic area (LHA) and have been implicated in the regulation of feeding, motor activity and the reward system.
Naoki Furutani +7 more
doaj +1 more source