Results 41 to 50 of about 6,179 (233)
Effects of orexins on 17β-estradiol synthesis and P450 aromatase modulation in the testis of alpaca (Vicugna pacos). [PDF]
, 2018 The steroidogenic enzyme P450 aromatase (ARO) has a key role in the conversion of testosterone (T) into estrogens (E), expressed as 17β-estradiol. The presence and localization of this key enzyme have not been described before in the South American ...
Assisi L +5 more
core +1 more source
Increased Numbers of CD4<sup>+</sup> T-Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1. [PDF]
Ann NeurolNarcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Shan L +5 more
europepmc +2 more sources
Pharmaceuticals, 2019 Much evidence indicates that hypothalamus-derived neuropeptides, oxytocin, orexins A and B, inhibit nociceptive transmission in the rat spinal dorsal horn.
Eiichi Kumamoto
doaj +1 more source
Hypothalamic orexinergic neuron changes during the hibernation of the Syrian hamster
Frontiers in Neuroanatomy, 2022 Hibernation in small mammals is a highly regulated process with periods of torpor involving drops in body temperature and metabolic rate, as well as a general decrease in neural activity, all of which proceed alongside complex brain adaptive changes that
Jesús M. López +6 more
doaj +1 more source
Research progress on the mechanism of orexin in pain regulation in different brain regions
Open Life Sciences, 2021 Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]).
Kang Xianhui +4 more
doaj +1 more source
Hypothalamic orexins as possible therapeutic agents in threat and spatial memory disorders
Frontiers in Behavioral Neuroscience, 2023 Orexin-A and orexin-B, neuropeptides produced exclusively in the lateral hypothalamus, have been implicated in various functions, including memory. Their levels are elevated in certain pathological states, such as PTSD, and lowered in other states, e.g.,
Filip Mazur, Jarosław Całka
doaj +1 more source
Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model [PDF]
, 2014 Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity andseveral eating disorders. Currently, little is known about the neuronal circuitries activated by the acute ingestion of arewarding ...
Patrone, Anabela +3 more
core +2 more sources
Angewandte Chemie International Edition, EarlyView.Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe +7 more
wiley +1 more source
Veterinary SciencesOrexins A (OXA) and B (OXB) and their specific receptors, receptor 1 (OX1R) and 2 (OX2R) for orexins, are hypothalamic peptides involved in orchestrating several functions in the central nervous system and peripheral organs, including sleep, excitement ...
Anna Costagliola +6 more
doaj +1 more source
AMPK in the central nervous system: physiological roles and pathological implications [PDF]
, 2016 5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain.
Fioramonti, Marco +6 more
core +1 more source