Results 41 to 49 of about 176 (49)

Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy

Neurobiology of Disease, 2018
The lateral hypothalamus contains neurons producing orexins that promote wakefulness and suppress REM sleep as well as neurons producing melanin-concentrating hormone (MCH) that likely promote REM sleep.
Fumito Naganuma, Sathyajit S. Bandaru, Gianna Absi, Carrie E. Mahoney, Thomas E. Scammell, Ramalingam Vetrivelan   +5 more
doaj   +1 more source

Activation of LH orexin neurons and VTA dopamine neurons is involved in anesthesia/surgery-induced sleep–wake disorders and delirium-like behaviors in mice

Scientific Reports
Postoperative delirium (POD) and sleep disorders are common surgical complications with a close clinical association, suggesting shared pathophysiological mechanisms mediated by neurotransmitters and neural circuits.
Shuang Han, Kun He, Longlu Cao, Sha Li, Lining Huang   +4 more
doaj   +1 more source

The effect of CA1 administration of orexin-A on hippocampal expression of COX-2 and BDNF in a rat model of orofacial pain

Arquivos de Neuro-Psiquiatria
The neuropeptide orexin-A and its receptors are widely distributed in both hippocampal circuitry and pain transmission pathways. Objective: Involvement of the CA1 orexin 1 receptor (OX1R) on the modulation of orofacial pain and pain-induced changes in ...
Razieh Kooshki, Mehdi Abbasnejad, Saeed Esmaeili-Mahani, Maryam Raoof   +3 more
doaj   +1 more source

Pharmacological or genetic orexin 1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex

Frontiers in Neuroscience, 2014
The orexin/hypocretin neuropeptides are produced by a cluster of neurons within the lateral posterior hypothalamus and participate in neuronal regulation by activating their receptors (OX1 and OX2 receptors).
Leah eAluisio, Ian eFraser, Tamara eBerdyyeva, Volha eTryputsen, Brock Thomas Shireman, James eShoblock, Tim eLovenberg, Christine eDugovic, Pascal eBonaventure   +8 more
doaj   +1 more source

Narcolepsy and Orexins: An Example of Progress in Sleep Research

Frontiers in Neurology, 2011
Narcolepsy is a chronic neurodegenerative disease caused by a deficiency of orexin-producing neurons in the lateral hypothalamus (LH). It is clinically characterized by excessive daytime sleepiness and by intrusions into wakefulness of physiological ...
Alberto K De La Herrán-Arita, Magdalena eGuerra-Crespo, René eDrucker-Colin   +2 more
doaj   +1 more source

Editorial: Hypocretins/Orexins

Frontiers in Endocrinology, 2020
Miguel López, Miguel López, Luis de Lecea, Carlos Diéguez, Carlos Diéguez   +4 more
doaj   +1 more source

Sleep, Energy and Depression

Dialogues in Clinical Neuroscience & Mental Health
Sleep is a universal biological behavior that to this day remains unclear. There is a lack of consensus concerning sleep’s underlying function, making it a controversial matter. Throughout the years, many theories have been formulated with the purpose to
Erietta Karaviti
doaj   +1 more source

Effect of Resistance Training on Appetite Regulation and Level of Related Peptidesin Sedentary Healthy Men

Medical Laboratory Journal, 2017
Background and Objectives: Resistance training is a key component of exercise recommendations for weight control, yet very little is known about the effects of resistance training on appetite and related peptides.
A Jafari, M Peeri, M Azarbayejani, H Homai   +3 more
doaj  

Regulation of neuronal plasticity associated with neuropsychiatric disorders by the orexinergic system

Heliyon
Orexins are a family of neuropeptides secreted by neurons in the lateral hypothalamus (LH). These peptides act widespreadly across the body by interacting with specific orexin receptors on target cells, which comprise the orexinergic system.
Fei Cao, Zhengyang Guo, Xiaodan Ma, Xuezhi Li, Qinqin Wang   +4 more
doaj   +1 more source