Results 31 to 40 of about 176 (49)
Tumor cell apoptosis mediated by the orexins
Медицинская иммунология, 2021 Orexins A and B are neuropeptides synthesized by a population of lateral hypothalamic neurons. Orexin’s physiological function consists mainly in regulating the sleep-wake cycle, eating behavior, and energy homeostasis. Axons of orexin-containing neurons
A. S. Diatlova +3 more
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Narcolepsy in the light of modern diagnostic, clinical and therapeutic concepts
Journal of Education, Health and Sport, 2018 Narcolepsy is a chronic neurological disease classified as hypersomnia of central origin. Core symptoms of the disease (hypersomnia and cataplexy) are particularly burdensome for patients. The etiology of the disease is not fully understood.
Adrian Kowalski +4 more
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BiomedicinesThe orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful
Miklós Jászberényi +4 more
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Brain SciencesBackground/Objectives: Gestational exposure to a high-fat diet (HFD) reprograms hypothalamic orexigenic circuits prenatally. However, whether astrocytes, critical modulators of this system, are also imprinted by HFD in the fetal brain remains unknown. We
Nuria Galindo-Solano +6 more
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Hormonal Changes in Menopause and Orexin-A Action
Obstetrics and Gynecology International, 2013 Menopause is a period of significant physiological changes that may be associated with increased body weight and obesity-related diseases. Many researches were conducted to assess the contribution of factors such as estrogen depletion, REE decline, and ...
Giovanni Messina +5 more
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Scientific Reports, 2017 The orexinergic system of the lateral hypothalamus plays a crucial role in maintaining wakefulness and mediating arousal in a circadian time-dependent manner.
Lukasz Chrobok +4 more
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Prolonged stress alters the PC1/PC2 ratio in the rat lateral hypothalamus, implicating impaired orexin maturation [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Stress elicits physiological and neuroendocrine responses mediated by the hypothalamic-pituitary-adrenal (HPA) axis and lateral hypothalamus (LH). However, prolonged stress can dysregulate neuropeptide systems like orexin.
Mohadeseh Salami +2 more
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Influence of sleep on seizures and interictal epileptiform discharges in epilepsy [PDF]
EncephalitisSleep significantly influences seizure occurrence and interictal epileptiform discharges (IEDs) in patients with epilepsy. Sleep-related epilepsy, where seizures occur exclusively or predominantly during sleep, has been observed in various epilepsy ...
Jun-Sang Sunwoo
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The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases
Frontiers in Molecular Neuroscience, 2018 Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein–coupled receptors (GPCRs), orexin ...
Chunmei Wang +8 more
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Chinese Medical Journal, 2015 Background: Sleep/wake disturbances in patients with amyotrophic lateral sclerosis (ALS) are well-documented, however, no animal or mechanistic studies on these disturbances exist.
Rong Liu +4 more
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