Results 11 to 20 of about 6,179 (233)

Functional cardiac orexin receptors : role of orexin-B/orexin 2 receptor in myocardial protection [PDF]

Clinical Science, 2018
Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In this study we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects.
Antoniades, Charalambos, Antonopoulos, Alexios, Chen, Jing, Dimitriadis, Georgios K., Hillhouse, Edward W., Karteris, Emmanouil, Kyrou, Ioannis, Mattu, Harman, Ng, Andre, Patel, Vanlata H., Randeva, Harpal S., Rodrigo, Glenn, Tan, Bee K.   +12 more
core   +10 more sources

Editorial: Hypocretins/Orexins

Frontiers in Endocrinology, 2020
Miguel López, Miguel López, Luis de Lecea, Carlos Diéguez, Carlos Diéguez   +4 more
doaj   +3 more sources

Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]

The Journal of Neuroscience, 2010
Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka, Sawako, Tabuchi, Tomomi, Tsunematsu, Yugo, Fukazawa, Makoto, Tominaga   +4 more
openaire   +2 more sources

Orexins and male reproduction

Asian Pacific Journal of Reproduction, 2019
Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. They occur in two known forms, namely, orexin A and orexin B with a common precursor, preproorexin. The orexin receptors (orexin 1R and orexin 2R) belong
Pallav Sengupta, Sulagna Dutta, Maiza Tusimin, Ivan Rolland Karkada   +3 more
doaj   +1 more source

Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Life, 2023
Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells.
Iman Mohammadi, Masoud Sadeghi, Golnaz Tajmiri, Annette Beatrix Brühl, Laleh Sadeghi Bahmani, Serge Brand   +5 more
doaj   +1 more source

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
A Bisetti, AJ Lawrence, Alice Y. W. Chang, AR Di Sebastiano, B Boutrel, B Boutrel, B Wang, BA Baldo, Beáta Á. Borsay, C Baimel, C Peyron, CM Kotz, CS Molnar, Csilla S. Molnár, CV Dayas, D Georgescu, D Sulzer, E Hirsch, E Hrabovszky, E Hrabovszky, Erik Hrabovszky, G Aston-Jones, G Martin, GC Harris, GC Harris, J Fadel, J Xia, JA Hollander, JJ Balcita-Pedicino, K Mukai, L de Lecea, László Herczeg, M Barrot, M Narita, NM Vittoz, NM Vittoz, Péter Gergely, R Fronczek, R Sharf, R Sharf, RM Chemelli, S Deurveilher, S Srinivasan, SL Borgland, SV Mahler, T Bullmann, T Nakamura, T Sakurai, TM Korotkova, TM Korotkova, XY Lu, Y Date, Z Liposits, Zsolt Liposits   +53 more
core   +2 more sources

Orexins in the clinical course of bipolar disorder

European Psychiatry, 2021
Introduction Orexins are involved in the regulation of circadian rhythms which play an important role in mood regulation(1,2), and are hypothesised to be associated with major depressive disorder(3).
C. Moya-Lacasa, M. Valtueña-García, E. Martín Gil, L. González-Blanco, M.P. García-Portilla   +4 more
doaj   +1 more source

Analysis of the characteristics of agitated behavior and its influencing factors in patients with cognition disorders

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Objective To analyze the correlations between plasma orexin⁃A and clinical manifestations of dementia with Lewy bodies (DLB). Methods A total of 51 patients with DLB from Beijing Tiantan hospital, Capital Medical University, and 46 sex, age and ...
Yu⁃chen QIAO, Hong CHANG, Jia⁃mei WANG, Xuan YANG, Na WEI, Ai⁃cong DING   +5 more
doaj   +1 more source

Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep-wakefulness cycle [PDF]

, 2013
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permissionThe perifornical area in the posterior lateral hypothalamus (PeFLH) has been implicated in several physiological functions ...
Garzón, Miguel, Núñez, Ángel, Rodrigo-Angulo, Margarita Lucía, Tortorella, Silvia   +3 more
core   +3 more sources

Genes and primary headaches: discovering new potential therapeutic targets [PDF]

, 2013
Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola, Gai, Annalisa, Gentile, Salvatore, Paemeleire, Koen, Pinessi, Lorenzo, Rainero, Innocenzo, Rubino, Elisa, Sarchielli, Paola, Vacca, Alessandro   +8 more
core   +3 more sources