Results 11 to 20 of about 176 (49)
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship
Frontiers in Behavioral Neuroscience, 2012 Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these
Andrezza Kyunmi Kim +3 more
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Frontiers in Oncology, 2022 Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-associated death in the West. This type of cancer has a very poor prognosis notably due to the development of chemoresistance when treatments including gemcitabine and Abraxane
Thierry Voisin +9 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Objective To analyze the correlations between plasma orexin⁃A and clinical manifestations of dementia with Lewy bodies (DLB). Methods A total of 51 patients with DLB from Beijing Tiantan hospital, Capital Medical University, and 46 sex, age and ...
Jing⁃huan GAN +4 more
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Orexins/Hypocretins: Key Regulators of Energy Homeostasis
Frontiers in Endocrinology, 2019 Originally described to be involved in feeding regulation, orexins/hypocretins are now also considered as major regulatory actors of numerous biological processes, such as pain, sleep, cardiovascular function, neuroendocrine regulation, and energy ...
Edward Milbank +3 more
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Children with Narcolepsy type 1 have increased T‐cell responses to orexins
Annals of Clinical and Translational Neurology, 2019 Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4+ and CD8+ T‐cells in response to
Andrew C. Cogswell +5 more
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Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone
Brain Sciences, 2022 Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2).
Martin A. Katzman, Matthew P. Katzman
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Frontiers in Endocrinology, 2013 The hypothalamus monitors body homeostasis and regulates various behaviors such as feeding, thermogenesis, and sleeping. Orexins (also known as hypocretins) were identified as endogenous ligands for two orphan G-protein-coupled receptors in the lateral ...
Ayumu eInutsuka +3 more
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Frontiers in Endocrinology, 2018 Orexins (OxA and OxB) also termed hypocretins are hypothalamic neuropeptides involved in central nervous system (CNS) to control the sleep/wake process which is mediated by two G protein-coupled receptor subtypes, OX1R, and OX2R.
Alain Couvineau +6 more
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Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies
Frontiers in Neurology, 2017 In the present article, we provide a review of current knowledge regarding the role played by physical activity (PA) in preventing age-related cognitive decline and reducing risk of dementia.
Sergio Chieffi +12 more
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Orexin system increases energy expenditure by brown adipose tissue activity
National Journal of Physiology, Pharmacy and Pharmacology, 2017 Adipose tissue is a biological caloric reservoir that expands itself in response to overnutrition and releases lipids in response to energy deficit. It comprises white adipose tissue, the main energy storage, and brown adipose tissue (BAT), a key site of
Antonietta Messina +11 more
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