Results 81 to 90 of about 102,789 (325)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Hubungan antara Tumor Necrosis Factor Alpha dengan Demam Berdarah Dengue

Sari Pediatri, 2016
Latar belakang. Sampai saat ini patogenesis demam berdarah dengue (DBD) belum dipahami secara sempurna. Pada kasus DBD didapatkan adanya peningkatan kadar TNF-α, sitokin yang poten dalam meningkatkan permeabilitas pembuluh darah.
Felix Candra Sutanto, Max F.J. Mantik, Vivekenanda Pateda   +2 more
doaj   +1 more source

High-resolution QTL mapping in Tetranychus urticae reveals acaricide-specific responses and common target-site resistance after selection by different METI-I acaricides [PDF]

, 2019
Arthropod herbivores cause dramatic crop losses, and frequent pesticide use has led to widespread resistance in numerous species. One such species, the two-spotted spider mite, Tetranychus urticae, is an extreme generalist herbivore and a major worldwide
Bajda-Wybouw, Sabina, Clark, Richard M, Dermauw, Wannes, Feyereisen, René, Greenhalgh, Robert, Kosterlitz, Olivia, Kurlovs, Andre, Snoeck, Simon, Van Leeuwen, Thomas, Villacis-Perez, Ernesto   +9 more
core   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Recent Advances and Challenges in Ammonia‐Hydrogen Energy Conversion

Advanced Science, EarlyView.
This work summarizes the latest progress of various catalytic methods in ammonia‐hydrogen energy conversion. The challenges and outlook of ammonia‐hydrogen energy conversion system are also emphasized. This work expects to build a blueprint of renewable and efficient ammonia‐hydrogen energy conversion systems under mild conditions.
Menghao Lv, Runchao Qin, Jianshuo Chen, Kaiwen Yang, Jianwei Lu, Weiwei Lei, Yifu Yu   +6 more
wiley   +1 more source

Gangguan Ginjal Akut pada Demam Berdarah Dengue

Sari Pediatri, 2016
Latar belakang. Demam berdarah dengue (DBD) merupakan masalah kesehatan masyarakat di berbagai bagian dunia, 50 juta orang terinfeksi virus dengue setiap tahun, 500.000 DBD syok (DSS) dengan angka kematian 2,5%. Tujuan.
Harun Arrasyd Rydha, Syarifuddin Rauf, Dasril Daud   +2 more
doaj   +1 more source

Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]

, 2014
In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Arriola, David J, Park, Chung Hyun, Rivera, Alissa J, Skarra, Danalea V, Thackray, Varykina G   +4 more
core   +3 more sources

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

KAJIAN KESIAPSIAGAAN KELUARGA DALAM MENGHADAPI KEJADIAN LUAR BIASA DBD DI KECAMATAN JAYA BARU KOTA BANDA ACEH

JKS (Jurnal Kedokteran Syiah Kuala), 2014
Abstrak. Penelitian ini bertujuan untuk mengetahui kesiapsiagaan keluarga dalam menghadapi KLB DBD dan untuk mengetahui hubungan  pengetahuan,  sikap, rencana tanggap darurat,sistem peringatan bencana dan mobilisasi sumber daya terhadap kesiapsiagaan ...
Nana Mirzana, Mudatsir Mudatsir, Mulyadi Mulyadi   +2 more
doaj  

Thyroid Hormone as a Method of Reducing Damage to Donor Hearts after Circulatory Arrest [PDF]

, 2017
There is a chronic lack of donor hearts to meet the need for heart transplant both in the US and worldwide. Further, the use of available hearts is limited by the short period between collection and implantation during which the heart can be safely ...
Adams, William P.
core   +1 more source