Results 21 to 30 of about 41,646 (264)

Analysis of tricarboxylic acid cycle intermediates in dried blood spots by ultraperformance liquid chromatography-tandem mass spectrometry

Journal of Biochemical and Clinical Genetics, 2019
Background: We developed a novel method for measuring the concentrations of tricarboxylic acid (TCA) cycle intermediates in dried blood spots (DBS) using liquid chromatography-tandem mass spectrometry (LC-MS/ MS).
Lamia Alhammadi, Maitha Aal Abdulla, Naila Ahli, Nahid Al Dhahouri, Anas Al Aidaros, Fatma Al-Jasmi, Osama Y. Al-Dirbashi   +6 more
doaj   +1 more source

Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation

Frontiers in Human Neuroscience, 2023
The deep brain stimulation (DBS) Think Tank X was held on August 17–19, 2022 in Orlando FL. The session organizers and moderators were all women with the theme women in neuromodulation. Dr. Helen Mayberg from Mt. Sinai, NY was the keynote speaker.
Joshua K. Wong, Helen S. Mayberg, Doris D. Wang, R. Mark Richardson, Casey H. Halpern, Lothar Krinke, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro’ee Gilron, James F. Cavanagh, Jack W. Judy, Svjetlana Miocinovic, Annaelle D. Devergnas, Roy V. Sillitoe, Stephanie Cernera, Carina R. Oehrn, Aysegul Gunduz, Wayne K. Goodman, Erika A. Petersen, Helen Bronte-Stewart, Robert S. Raike, Mahsa Malekmohammadi, David Greene, Petra Heiden, Huiling Tan, Jens Volkmann, Valerie Voon, Luming Li, Pankaj Sah, Terry Coyne, Peter A. Silburn, Cynthia S. Kubu, Anna Wexler, Jennifer Chandler, Nicole R. Provenza, Sarah R. Heilbronner, Marta San Luciano, Christopher J. Rozell, Michael D. Fox, Coralie de Hemptinne, Jaimie M. Henderson, Sameer A. Sheth, Michael S. Okun   +45 more
doaj   +1 more source

Pedunculopontine and Cuneiform Nuclei Deep Brain Stimulation for Severe Gait and Balance Disorders in Parkinson’s Disease: Interim Results from a Randomized Double-Blind Clinical Trial

Journal of Parkinson’s Disease, 2022
Background: Dopa-resistant freezing of gait (FOG) and falls represent the dominant motor disabilities in advanced Parkinson’s disease (PD). Objective: We investigate the effects of deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR),
Julie Bourilhon, Claire Olivier, Hana You, Antoine Collomb-Clerc, David Grabli, Hayat Belaid, Yannick Mullie, Chantal François, Virginie Czernecki, Brian Lau, Fernando Pérez-García, Eric Bardinet, Sara Fernandez-Vidal, Carine Karachi, Marie-Laure Welter   +14 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

TOURISM IN UTTARAKHAND, INDIA: COSTS AND POLICY RESPONSES FOR SUSTAINABLE DEVELOPMENT [PDF]

Geo Journal of Tourism and Geosites
This study examines Uttarakhand’s tourism system from a spatial–systems lens to identify the key economic, environmental, and socio-cultural costs associated with rapid tourism expansion, and to assess whether current governance responses are adequate.
Shailja KHANDURI
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Nanoparticle shapes effects on unsteady physiological transport of nanofluids through a finite length non-uniform channel

Results in Physics, 2017
An analytical investigation is presented to study the unsteady peristaltic transport of nanofluids. Three different geometries of nanoparticle viz bricks, cylinder and platelets are considered in our analysis.
Noreen Sher Akbar, Adil Wahid Butt, Dharmendra Tripathi   +2 more
doaj   +1 more source

Directions of Deep Brain Stimulation for Epilepsy and Parkinson’s Disease

Frontiers in Neuroscience, 2021
BackgroundDeep brain stimulation (DBS) is an effective treatment for movement disorders and neurological/psychiatric disorders. DBS has been approved for the control of Parkinson disease (PD) and epilepsy.ObjectivesA systematic review and possible future
Ying-Chang Wu, Ying-Siou Liao, Wen-Hsiu Yeh, Sheng-Fu Liang, Sheng-Fu Liang, Fu-Zen Shaw, Fu-Zen Shaw   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Entropy Generation Analysis for a CNT Suspension Nanofluid in Plumb Ducts with Peristalsis

Entropy, 2015
The purpose of the current investigation was to discuss the entropy generation analysis for a carbon nanotube (CNT) suspension nanofluid in a plumb duct with peristalsis. The entropy generation number due to heat transfer and fluid friction is formulated.
Noreen Sher Akbar
doaj   +1 more source