Results 51 to 60 of about 549,171 (289)

A Tutorial and Review Discussion of Modulation, Control and Tuning of High-Performance DC-DC Converters Based on Small-Signal and Large-Signal Approaches

IEEE Open Journal of Power Electronics, 2020
Many commercial controller implementations for dc-dc converters are based on pulse-width modulation (PWM) and small-signal analysis. Increasing switching frequencies, linked in part to wide bandgap devices, provide the opportunity to increase operating ...
S. Kapat, P. Krein
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Projecting GaN HEMTs lifetimes under typical stresses commonly observed in DC-DC converters

Power Electronic Devices and Components, 2023
DC-DC converters exist in virtually every application of modern power electronics. Due to small die size, low on-resistance, and low parasitic capacitance, GaN power devices offer superior conversion efficiency and record-setting power density.
Shengke Zhang, Siddhesh Gajare, Ricardo Garcia, Sijun Huang, Angel Espinoza, Andrea Gorgerino, Ruizhe Zhang, Alejandro Pozo, Robert Strittmatter, Alex Lidow   +9 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Analysis and Optimization of DC-DC Converters Through Sensitivity to Parametric Variations

Technologies
The optimization of DC-DC converters is crucial for enhancing their performance and efficiency in various applications. This study focuses on the sensitivity analysis of DC-DC converters to parametric variations, which plays a key role in designing ...
Nikolay Hinov, Plamen Stanchev, Gergana Vacheva   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

DC fault protection strategy considering DC network partition [PDF]

, 2016
This paper investigates DC network partition and alternative DC fault protection strategy for Multi-terminal HVDC (MTDC) system. Fast acting DC Circuit Breakers (DCCBs) or fault blocking DC-DC converters can be configured at strategic locations to allow ...
Rahman, Md Habibur, Xu, Lie, Yao, Liangzhong   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Review of dc-dc converters for multi-terminal HVDC transmission networks [PDF]

, 2016
This study presents a comprehensive review of high-power dc-dc converters for high-voltage direct current (HVDC) transmission systems, with emphasis on the most promising topologies from established and emerging dc-dc converters.
Ased, Grain Philip, Finney, Stephen Jon, Gowaid, Islam Azmy, Holliday, Derrick, Williams, Barry W.   +4 more
core   +1 more source