Results 241 to 250 of about 972 (272)
Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output
Advanced Science, EarlyView.Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin +2 more
wiley +1 more source
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian +7 more
wiley +1 more source
Advanced Science, EarlyView.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
Personalized Network‐Guided Neuromodulation Enhances Human Working Memory
Advanced Science, EarlyView.A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan +13 more
wiley +1 more source
Comparative study of AC/DC convertors with unity power factor
G. Roy, M.C. Ghanem, K. Al-Haddad
core +1 more source
Modeling human wellbeing on a finite planet towards 2100 with Earth4All
Collste D +6 more
europepmc +1 more source
Saturable reactor assisted soft-switching full-bridge DC-DC power convertors
IEE Proceedings B Electric Power Applications, 1991 A new soft-switching converter technique is introduced which employs small saturable reactors and phase-shift modulation. This considerably reduces switching losses with no substantial increase in conduction losses. The proposed soft-switching concept and its modifications to full-bridge DC-DC power convertors are shown and discussed.
S. Hamada, Y. Ogino, M. Nakaoka
exaly +4 more sources
Discussions on control loop design in average current mode control [PWM DC/DC power convertors]
Conference Record of the 2000 IEEE Industry Applications Conference. Thirty-Fifth IAS Annual Meeting and World Conference on Industrial Applications of Electrical Energy (Cat. No.00CH37129), 2002 Large control output ripple in ACMC (average current mode control) PWM DC/DC converters exposes challenges in accurate modeling and design. In this paper, superposition models are utilized to perform control design analysis for ACMC PWM DC/DC converters.
null Chunxiao Sun, B. Lehman
openaire +2 more sources