Results 211 to 220 of about 2,216,872 (294)

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

open access: yesAdvanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian   +14 more
wiley   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

open access: yesAdvanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng   +6 more
wiley   +1 more source

Self‐Responsive Plastron Maintenance on a Superhydrophobic Mesh via Locally Integrated Electrolysis

open access: yesAdvanced Science, EarlyView.
This work presents a self‐switchable SHM‐E surface that enables rapid, autonomous plastron self‐repair and long‐term stability. Plastron loss triggers circuit closure and localized electrolysis, while capillary spreading rapidly restores a continuous plastron and self‐terminates the current.
Jiaming Wang, Zhen Zhang, Yuhong Liu
wiley   +1 more source

Opposite Trap‐State Evolution Pathways Govern Endurance and Retention Failure in Amorphous Chalcogenide Memory

open access: yesAdvanced Science, EarlyView.
GeSbSe selector‐only memory devices are investigated through physical and electrical analyses to reveal opposite trap‐state evolution pathways governing reliability degradation. Endurance cycling drives Se migration, transitioning traps from deep to shallow states.
Byung Jun Lee   +3 more
wiley   +1 more source

Unraveling the Effects of Depolarization in Ultrathin Barium Titanate

open access: yesAdvanced Science, EarlyView.
This article employs synchrotron‐based spectroscopy, time‐resolved electrical measurements, and phase‐field simulations to establish reverse‐domain formation as the mechanism of polarization loss in ultrathin BaTiO3${\rm BaTiO}_3$ films as a critical obstacle to low‐voltage ferroelectric devices.
Thomas Lee   +6 more
wiley   +1 more source

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