Results 41 to 50 of about 4,477,185 (228)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

A Cycle-Based Formulation and Valid Inequalities for DC Power Transmission Problems with Switching

open access: yes, 2015
It is well-known that optimizing network topology by switching on and off transmission lines improves the efficiency of power delivery in electrical networks. In fact, the USA Energy Policy Act of 2005 (Section 1223) states that the U.S.
Dey, Santanu S.   +5 more
core   +1 more source

Optimal PWM control of switched-capacitor DC/DC power converters via model transformation and enhancing control techniques [PDF]

open access: yes, 2008
—This paper presents an efficient and effective method for an optimal pulse width modulated (PWM) control of switched-capacitor DC/DC power converters.
Ho, Charlotte Yuk-Fan   +4 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Boost converter fed high performance BLDC drive for solar PV array powered air cooling system [PDF]

open access: yes, 2017
This paper proposes the utilization of a DC-DC boost converter as a mediator between a Solar Photovoltaic (SPV) array and the Voltage Source Inverters (VSI) in an SPV array powered air cooling system to attain maximum efficiency.
Depuru, Shobha Rani   +1 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Functioning of Primary Health Centers in the Selected Tribal Districts of Karnataka-India: Some Preliminary Observations [PDF]

open access: yes, 2011
The study was intended to find how the Primary Health Centers in the Selected Tribal Districts of Karnataka-India are functioning and to reveal their problems and prospects.
DC, Nanjunda
core   +1 more source

Improvement of speed response in four-phase DC–DC converter switching using two shunt voltage-source [PDF]

open access: yes, 2018
This study proposes a technique that is able to improve the speed response of a four-phase DC–DC converter switching. The basic concept of the proposed technique is the inclusion of two shunt-connected voltage sources in series to the converter system ...
A. Yahaya, Jabbar   +2 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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