Results 61 to 70 of about 3,706,735 (305)
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Step-up DC-DC converter passive component dimensioning in photovoltaic applications
2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, 2012 Boost converter is a common solution for power conditioning of photovoltaic systems. Inductance and capacitance values of the boost converter are of high importance when the panel voltage ripple is examined. The ripple has a severe effect on the maximum power point tracking efficiency.
Hannonen Janne +3 more
openaire +2 more sources
An analysis of bidirectional superposed dual active bridge DC-DC converter with synchronous rectifier [PDF]
, 2010 This paper describes the principles and characteristics of a novel bidirectional superposed dual active bridge DC-DC converter with synchronous rectifier, which has a mechanism formed from two bridge-type converters that are linked through superposition ...
Takayuki Kimura +7 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Analysis of DC–DC converters as critical components for maritime DC grid simulation
Electric Power Systems ResearchThe level of simulation detail accounts for system stability and dynamic response performance and is key to optimize between simulation accuracy and complexity. This study investigate its impact in shipboard DC grids focusing on power electronic converters as a critical component.
Marlin Malpricht +2 more
openaire +1 more source
, 2019 © 2019 IEEE. This paper proposes a new non-isolated, high step-up DC-DC converter to interface renewable sources into DC microgrid. The topology utilizes the coupled inductor and switched capacitor techniques to achieve high step-up voltage conversion ...
Gautam, Samir +11 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
IEEE Photonics Journal, 2016 In this paper, we propose an intensity demodulation based fiber sensor for dual-parameters sensing of acoustic wave and lateral pressure. The sensor consists of a long period fiber grating (LPFG) inserted into a Sagnac interferometer (SI).
Xin Fu +6 more
doaj +1 more source