Results 241 to 250 of about 1,075,155 (309)

Mucosal Adenovirus-Vectored Rv2299c Vaccine Protects Against Tuberculosis by Inducing Trained Immunity in Dendritic Cells and Polyfunctional T Cells. [PDF]

Vaccines (Basel)
Wang H, Xie S, Huang S, Huang X, Zhang Y, Wu J, Fan XY, Hu Z.   +7 more
europepmc   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

<i>Anaplasma phagocytophilum</i> invasin AipB interacts with the β2 integrin β-subunit CD18 to orchestrate infection. [PDF]

mBio
Lind MCH, Naimi WA, Hunt JR, Izac JR, Marconi RT, Carlyon JA.   +5 more
europepmc   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Do natural or synthetic excito-repellents work better? A study on coastal malaria vector <i>Anopheles epiroticus</i> in Ko Chang, Thailand. [PDF]

PeerJ
Sukkanon C, Jabjai S, Ritthison W, Chareonviriyaphap T, Nararak J.   +4 more
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Recombinant ROP8 antigen: diagnostics, immunogenicity, and therapeutic targeting in toxoplasmosis. [PDF]

Front Immunol
Chyb M, Bekier A, Kawka M, Ferra B, Dziadek B, Michlewska S, Dzitko K, Trotsko N, Gatkowska J.   +8 more
europepmc   +1 more source

Study on the Mechanical Property Degradation Laws of 6061-T6 Aluminum Alloy Under the Synergistic Effect of Corrosion and Cyclic Loading. [PDF]

Materials (Basel)
Long Q, Nie X, Yan C, Chen Z, Li Z, Chen S, Huang Z.   +6 more
europepmc   +1 more source

Identification of DC-174 as a Novel Hydroxamic Precandidate for the Development of an Oral Snakebite Treatment. [PDF]

J Med Chem
Chong DJW, Albulescu LO, Westhorpe A, Clare RH, Marriott AE, Woodley CM, Gunasekar R, Mosallam N, Crittenden E, Stars E, Dawson C, Kool J, Wilkinson MC, Leung SC, Berry NG, Casewell NR, O'Neill PM.   +16 more
europepmc   +1 more source

Design of Mucosal Vaccines Against Swine Enteric Coronaviruses: From Antigen Delivery to Immune Activation. [PDF]

Transbound Emerg Dis
Pan Q, Sun Y, Bai H, Wang W, Liu B, Li M, Gao A, Zheng D, Jiang W, Hu H, Zhang H, Xiang Y, Wei Z, Zheng L.   +13 more
europepmc   +1 more source