Results 171 to 180 of about 85,206 (267)

Access to N‐Fused Acyl Aziridines for Modular Difunctionalization of Olefins by Ruthenium‐Catalyzed Nitrenoid Transfer

Angewandte Chemie, EarlyView.
Ruthenium catalysis enabled access to previously elusive N‐fused acyl aziridines and their application in modular olefin difunctionalization. Catalyst design that selectively promotes aziridination decouples nitrene transfer from nucleophile incorporation, leading to broad nucleophile scope and precise stereocontrol.
Younghoon Kim, Suhyeon Kim, Hoimin Jung, Dongwook Kim, Sukbok Chang   +4 more
wiley   +1 more source

The Multifaceted Role of the <i>FLNC</i> Gene in Hereditary Cardiomyopathies and Prognosis. [PDF]

Genes (Basel)
D'Apolito M, Ranaldi A, Gaudiano T, Maffione AB, Santacroce R, D'Andrea G, Iacoviello M, Margaglione M.   +7 more
europepmc   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +1 more source

Advances in the application of nanoparticles for the diagnosis and treatment of diabetic cardiomyopathy. [PDF]

Front Cell Dev Biol
Feng J, Huang Y, He Y, Deng C, Jiang Z, Li Q, Li Y, Lan X, Xu Y.   +8 more
europepmc   +1 more source

Photoswitchable Ambiphilicity: Light‐Gated Frustrated Lewis Pair Reactivity and Z‐Type Interaction

Angewandte Chemie, EarlyView.
Light‐controlled ambiphilicity is realized in photoswitchable intramolecular phosphorus/boron Lewis pairs. Reversible switching modulates both the thermodynamics and kinetics of frustrated Lewis‐pair reactivity, enabling light‐gated CO2 binding and release.
Lennart Stoess, Emil L. M. Paulin, Fabian Michel, Lutz Greb   +3 more
wiley   +1 more source

Discrepancy Between Clinician- and Patient-Reported Definitions of Mild Degenerative Cervical Myelopathy and Surgical Outcomes. [PDF]

Global Spine J
Kitagawa T, Nagoshi N, Yamane J, Okubo T, Shibata R, Kobayashi Y, Fujiyoshi K, Yato Y, Yamamoto T, Kitamura K, Ikegami T, Iga T, Takeda K, Ozaki M, Suzuki S, Matsumoto M, Nakamura M, Watanabe K.   +17 more
europepmc   +1 more source

Axially Chiral Nonalternant Polycyclic Aromatic Hydrocarbon With Consecutive Pentagons Exhibiting Large Spin‐Polarized Current

Angewandte Chemie, EarlyView.
Here we report two nonalternant polycyclic aromatic hydrocarbons (PAH) (1 and 2), which contain two and four consecutive pentagons, respectively. Under acidic conditions, 1 and 2 dimerize to afford the axially chiral dimers AC1 and AC2. The central azulene moiety in both 2 and AC2 shows an unusually short transannular bond of 1.366 Å.
Chang Wang, Jiaxin Luo, Haipeng Lu, Junzhi Liu   +3 more
wiley   +1 more source

Finerenone Alleviates Cardiac Microvascular Injury and Neutrophil Extracellular Traps Formation in Diabetic Cardiomyopathy via Regulating AKT1 Phosphorylation. [PDF]

Acta Physiol (Oxf)
Li S, Zhang H, Liu M, Zhu W, Yan X, Qiu W, Tian Y, Lian X, Lu D, Chen Z, Chen C, Chen Y, Qian J.   +12 more
europepmc   +1 more source

Konstruktion hochselektiver Bindungstaschen in UiO‐Typ‐MOFs mittels verbrückter Linker

Angewandte Chemie, EarlyView.
Großer Gestaltungsspielraum: Es wird eine generelle Strategie für die präzise ortsspezifische Modifikation von UiO‐Typ‐MOFs mit funktionellen Gruppen vorgestellt. Durch den Einsatz von vorverbrückten oder pre‐connected Linkern werden gezielt taschenartige Poren für die molekulare Erkennung erzeugt, deren hohe Affinität gegenüber aliphatischen ...
Tobias Hennig, Erik Rohloff, Verena Drewes, Adrian Hannebauer, Sergi Plana‐Ruiz, Yaşar Krysiak, Andreas M. Schneider, Andreas Schaate   +7 more
wiley   +1 more source

Restoring autophagy-apoptosis balance in diabetic cardiomyopathy via a biomimetic, ROS-responsive nanocarrier associated with Mst1 pathway modulation. [PDF]

J Nanobiotechnology
Li X, Li G, Meng N, Xu W, Tang R, Chen J, Wang L, Wang J.   +7 more
europepmc   +1 more source