Results 131 to 140 of about 21,319 (267)

Mechanistic target of rapamycin complex-1 plays a role in inhibiting kidney K⁺ excretion during overnight dietary K⁺ restriction. [PDF]

Am J Physiol Renal Physiol
Zheng JY, Duan XP, Wang WH, Lin DH.
europepmc   +1 more source

FEWT: Frequency‐Enhanced Wavelet‐Based Transformer for Multimodal Wheeled Bimanual Manipulation

SmartBot, EarlyView.
An embodied mobile bimanual robot learns dexterous manipulation skills through imitation learning with multimodal perception. The integration of vision, proprioception, and tactile sensing establishes a comprehensive perception–action loop, enabling the robot to continuously understand, interact with, and adapt to complex physical environments.
Jiaxin Huang, Hanyu Liu, Yunsheng Ma, Jian Shen, Yilin Zheng, Jiayi Wen, Zhigong Song   +6 more
wiley   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

How do communication, trust and professional relationships shape decentralised clinical trials? A qualitative interview study of international stakeholders. [PDF]

BMJ Open
Coyle J, Rogers A, Copland RR, Mackenzie IS.   +3 more
europepmc   +1 more source

Impact of general anaesthesia on immune response to first rabies vaccination in seronegative domestic cats

Veterinary Record, EarlyView.
Abstract Background Despite common concerns, evidence that anaesthesia impairs vaccine efficacy remains limited. This study assessed the impact of general anaesthesia on the immune response to rabies vaccination in cats. Methods Thirty‐five healthy female cats (6–12 months old) undergoing elective spaying were enrolled.
Pierre Bessière, Romane Breysse, Marion Chrétien, Brandon Hayes, Séverine Boullier, Anouck Labadie, Jonathan Rieder, Marine Wasniewski, Géraldine Jourdan   +8 more
wiley   +1 more source

Correction for Barker et al., "Mutations in <i>TAC1B</i> drive <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>Candida auris</i>". [PDF]

Antimicrob Agents Chemother
Barker KS, Santana DJ, Zhang Q, Peters TL, Rybak JM, Morschhäuser J, Cuomo CA, Rogers PD.   +7 more
europepmc   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Standardized totally endoscopic non-robotic mitral valve repair for degenerative mitral regurgitation: early single-center outcomes in 84 patients. [PDF]

Glob Cardiol Sci Pract
Thuan PQ, Chuong PTV, Khang CD, Dinh NH.
europepmc   +1 more source

Robust steganographic framework for securing sensitive healthcare data of telemedicine using convolutional neural network

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract Data is the key element that runs the modern society. Large amounts of data are being released day by day as a result of many activities. The digital data is transferred through the Internet which may be vulnerable to attacks while transmitting. Especially, the medical data is observed to be of at most importance.
Rupa Ch, Venkayya Yadlapalli, Suhana Sulthana Sk, G. Thippa Reddy, Sandeep Kautish   +4 more
wiley   +1 more source