Results 191 to 200 of about 38,586 (315)

A Multiregional Decentralized Clinical Trial Program to Improve Access.

JAMA Netw Open
Haddad TC, Mercado LA, Le-Rademacher JG, Enarson DA, Sener U, Kumar A, Price KA, Juhn YJ, Cartin-Ceba R, Colon-Otero G, Willman CL, Garovic VD, Kottschade RS.   +12 more
europepmc   +1 more source

Association between decentralised clinical trial adoption and trial duration: a retrospective cross-sectional study of metabolic disease trials. [PDF]

BMJ Open
Cho KH, Lee SW.
europepmc   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Simulation-free spine palliative radiotherapy enabled by AI-adapted diagnostic CT. [PDF]

Med Phys
Han Y, Hanania AN, Siddiqui ZA, Ugarte V, Zhou B, Mohamed ASR, Pathak P, Hamstra DA, Sun B.   +8 more
europepmc   +1 more source

الإخفاء الهجین فی ملفات الوسائط المتعددة

Al-Rafidain Journal of Computer Sciences and Mathematics, 2012
Farah Tareq Mohammed
doaj   +1 more source

In Situ Expression of miR‐371a‐3p and miR‐373‐3p in Testicular Germ Cell Tumours and Detection in Serum

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCTs) are the most common type of tumour diagnosed in young men, and reliable non‐invasive biomarkers are crucial for clinical management. MicroRNAs (miRNAs) from the miR‐371–373 cluster have recently been identified as novel and more sensitive serum biomarkers than the conventional protein‐based ...
Nina Mørup, Merve Tatli, Thomas Wagner, Helle Margit Albrechtsen, Gülizar Saritas, Gedske Daugaard, Sofia B. Winge, Kristian Almstrup   +7 more
wiley   +1 more source

Single-cell transcriptomics identifies ergothioneine as a mitochondrial protector to prevent AKI-to-CKD progression. [PDF]

PLoS One
Peng J, Chen J, Qian Z, Han M, Chen L.
europepmc   +1 more source

Towards an ‘absolute’ timing of biostratigraphic and environmental phases from the Saalian late glacial to the Weichselian pleniglacial in central Europe—Insights from a lacustrine succession in Lichtenberg, northern Germany

Boreas, EarlyView.
Palynological records are central to the biostratigraphic subdivision of the Late Pleistocene in central Europe. Yet many interglacial and interstadial phases—such as the Eemian, Brörup and Odderade—remain only poorly constrained in time due to limited numerical dating.
Michael Hein, Thomas Kasper, Alexis Badai Samudra, Martin Theuerkauf, Markus Lothar Fischer, Neda Rahimzadeh, Maria Sekar Proborukmi, Sonja Rigterink, Agnieszka Gruszczyńska, Christian Zeeden, Simon Parfitt, David John Horne, Lucy Roberts, Dustin White, Lisa Brogmus, Hans von Suchodoletz, Tobias Lauer, Marcel Weiss, David Colin Tanner, Brigitte Urban   +19 more
wiley   +1 more source

Comparative modulation of the gut microbiota by date-derived products and refined sugar: a 16S rRNA gene taxonomic profile in healthy rats. [PDF]

Front Microbiol
Alqurashi RM, Al-Mssallem MQ, Al-Majed AW, Almaghasla MI, Alarifi SN.   +4 more
europepmc   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source