Results 181 to 190 of about 113,946 (294)

Fibulin 2 Deficiency Drives Epigenetic Hypertension. [PDF]

Hypertension
Han X, Sun Z.
europepmc   +1 more source

Optimized TadA‐derived base editors efficiently manipulate mRNA splicing by A‐to‐G and C‐to‐K editing in potato

Journal of Integrative Plant Biology, EarlyView.
Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen, Yan Zhang, Jiuzhou Deng, Lumin Zhang, Huiying Zhou, Yaxin Duan, Enle Xiao, Guangtao Zhu, Chunzhi Zhang   +8 more
wiley   +1 more source

The influence of ocular parameters on intraocular pressure values measured by different devices and the development of an optimized prediction model in a myopic population. [PDF]

Adv Ophthalmol Pract Res
Gan W, Zhang Y, Yang S, He P, Hu Q, Du Z.   +5 more
europepmc   +1 more source

CO2‐sensitive K+ channel traffic affects stomata and whole‐plant water use

Journal of Integrative Plant Biology, EarlyView.
CO2‐responsive regulation of membrane trafficking influences the density of the potassium ion (K+) channel KAT1 at the plasma membrane. CO2‐sensitive traffic, dependent on trafficking by the SNARE SYP121, impacts stomatal gas exchange and plant growth.
Zhiyi Yu, Sakharam Waghmare, Sahar Farami, Michael R. Blatt, Rucha Karnik   +4 more
wiley   +1 more source

Dynamic and differential renal cortical cell-specific mitochondrial metabolism in response to fasting. [PDF]

Am J Physiol Renal Physiol
Feola K, Venable AH, Rasouli M, Do J, McCoy T, Llamas CB, Straus D, Russell JC, Mishra P, Najafian B, Huen SC.   +10 more
europepmc   +1 more source

The Expression and Potential Role of MicroRNAs in Oral Lichen Planus

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Oral lichen planus (OLP) is a chronic T‐cell‐mediated immune disease of unknown aetiology. MicroRNA (miRNAs) are short non‐coding RNAs capable of regulating mRNA and may have roles in T‐cell‐related diseases. The aim of this study was to investigate the profile of miRNAs in OLP patients and its interaction with potential target ...
Mousa Ali Heba, Resteu Anastasia, Werner Andreas, Carrozzo Marco   +3 more
wiley   +1 more source

ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity. [PDF]

JACC Basic Transl Sci
Wu B, Chen JCH, Ma CHY, Kwok M, Chan VT, Sung CC, Song Y, Zhang T, Lam HS, Meng F, Liang Y, Tsoi C, Deng R, Tsui SKW, Leung KT, Wang CC, Chan GCF, Boheler KR, Chung KKK, Poon EN.   +19 more
europepmc   +1 more source

Unilateral Action on Climate Change and the Moral Obligation to Take Leadership

Journal of Social Philosophy, EarlyView.
ABSTRACT We claim that a moral obligation to take climate leadership by means of unilateral mitigation depends on the existence of a plausible follow‐the‐leader mechanism whereby unilateral mitigation by some increases the probability of sufficient mitigation by others to avert catastrophic climate impacts.
Daniel Steel, Rachel Cripps, C. Tyler DesRoches, Paul Bartha, Kian Mintz‐Woo   +4 more
wiley   +1 more source

Considerations on the implementation of DCT: a SCAT-based analysis of fact-finding interviews in Europe and the United States, with implications for regions newly adopting DCT, including Japan. [PDF]

Front Med (Lausanne)
Taruno H, Ikeda K, Oikawa M, Sato T, Suzuki Y, Shikano M.   +5 more
europepmc   +1 more source

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source