Results 161 to 170 of about 21,319 (267)

In Situ Expression of miR‐371a‐3p and miR‐373‐3p in Testicular Germ Cell Tumours and Detection in Serum

open access: yesAndrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCTs) are the most common type of tumour diagnosed in young men, and reliable non‐invasive biomarkers are crucial for clinical management. MicroRNAs (miRNAs) from the miR‐371–373 cluster have recently been identified as novel and more sensitive serum biomarkers than the conventional protein‐based ...
Nina Mørup   +7 more
wiley   +1 more source

Towards an ‘absolute’ timing of biostratigraphic and environmental phases from the Saalian late glacial to the Weichselian pleniglacial in central Europe—Insights from a lacustrine succession in Lichtenberg, northern Germany

open access: yesBoreas, EarlyView.
Palynological records are central to the biostratigraphic subdivision of the Late Pleistocene in central Europe. Yet many interglacial and interstadial phases—such as the Eemian, Brörup and Odderade—remain only poorly constrained in time due to limited numerical dating.
Michael Hein   +19 more
wiley   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

open access: yesBrain Pathology, EarlyView.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni   +22 more
wiley   +1 more source

Honokiol regulates Acute respiratory distress syndrome (ARDS)‐associated pulmonary fibrosis via the miR‐19a‐3p/POSTN axis

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Acute respiratory distress syndrome (ARDS) and subsequent pulmonary fibrosis are associated with high mortality and limited treatment options. Periostin (POSTN) is a profibrotic mediator predicted to be regulated by microRNA‐19a‐3p (miR‐19a‐3p), but the relevance of this axis in ARDS‐associated pulmonary fibrosis remains
Weilun Liu   +14 more
wiley   +1 more source

Tissue Factor‐High Ovarian Clear Cell Carcinoma Shows Immune‐Cold Features and Preclinical Activity of Tisotumab Vedotin

open access: yesCancer Science, EarlyView.
F3/TF‐high ovarian clear cell carcinoma exhibits an immune‐cold phenotype characterized by reduced immune‐cell fractions and attenuated cancer‐cell interferon programs, with frequent B7‐H4 co‐expression. Patient‐derived models show preclinical sensitivity to the TF‐directed antibody–drug conjugate tisotumab vedotin.
Yutaro Mori   +7 more
wiley   +1 more source

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