Results 231 to 240 of about 38,586 (315)

Neuregulin 4‐dependent MAPK amplification mediates urate‐induced β‐cell dysfunction

Journal of Diabetes Investigation, EarlyView.
Hyperuricemia impairs glucose homeostasis by inducing pancreatic β‐cell apoptosis without insulin resistance. In male Uox‐KO mice, urate upregulates Nrg4, which amplifies MAPK signaling and drives β‐cell death. Thus, hyperuricemia disrupts glucose metabolism via the Nrg4‐MAPK axis.
Yunyang Wang, Kun Zhang, Zhiyuan Li, Shuhui Hu, Yiru Zhang, Yulei Zhao, Xiaohan Liu, Jie Lu   +7 more
wiley   +1 more source

Streamlining Paediatric Palliative Radiotherapy: A Case Study on Reducing Procedural Burden and Avoiding General Anaesthesia Using a Simulation-Free Radiotherapy (SF-RT) Protocol. [PDF]

J Med Radiat Sci
Eriksen A, Murphy L, Chard J, Wheeler G, Poon WY, Yau L, Ungureanu E, Thompson K, Woodford K.   +8 more
europepmc   +1 more source

Assessment of two minimally invasive methodologies for sex identification in the European eel, Anguilla anguilla

Journal of Fish Biology, EarlyView.
Abstract Sex is an important driver of variation in behaviour, ecology and physiology. Sex identification in the Critically Endangered European eel (Anguilla anguilla) currently requires fish sacrifice, or the use of morphological differences such as body length, which can be inaccurate in certain habitats and at intermediate body lengths.
Michael J. Williamson, Jack A. Brand, Kevin Hopkins, Luke O'Connor, Matthew W. Perkins, Christopher Sergeant, Simon Spiro, Taina Strike, Jessica Whinfield, Rosie S. Williams, Ethan Wrigglesworth, Rosalind M. Wright, Adam T. Piper   +12 more
wiley   +1 more source

Who gets included? Equity in digital and decentralised mental health and neurodevelopmental trials: A systematic review. [PDF]

PLOS Digit Health
Hall SS, Hall CL, Partlett C, Jeayes A, Rattu N, Henshaw H, Martin J, Shoesmith E.   +7 more
europepmc   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, EarlyView.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

SpecBEV: An End-to-End BEV 3D Object Detection Algorithm Based on Frequency-Domain Analysis and Geometric Alignment. [PDF]

Sensors (Basel)
Lin Y, Jia S.
europepmc   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, EarlyView.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

Clinical evaluation of corneal elasticity and true IOP using a dual-applanation tonometer. [PDF]

Front Ophthalmol (Lausanne)
Caruso C, Barbaro G, Troisi M, Matarazzo F, Costagliola C.   +4 more
europepmc   +1 more source

Transcriptional adapter ADA2 regulates yield and end‐use quality through liquid–liquid phase separation in wheat

Journal of Integrative Plant Biology, EarlyView.
The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang, Ruijie Zhang, Yuhan Zhang, Tao Yang, Longfei Wu, Yuan Cao, Jun Xiao, Jigang Li, Xin Gao, Xinyou Cao, Jie Liu, Mingming Xin, Yuan Zong, Zhongfu Ni, Qixin Sun, Yingyin Yao   +15 more
wiley   +1 more source

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism. [PDF]

Front Pharmacol
Shen Y, Yao B, Guo Y, Yang Y, Liang C, Huang J, Zhang Y, Wang X.   +7 more
europepmc   +1 more source