Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen +8 more
wiley +1 more source
Decomposition of Molecular Charge and Spin Transfer Global Indexes into Atomic Group Contributions. [PDF]
Gatti C, Danten Y, Frayret C.
europepmc +1 more source
CO2‐sensitive K+ channel traffic affects stomata and whole‐plant water use
CO2‐responsive regulation of membrane trafficking influences the density of the potassium ion (K+) channel KAT1 at the plasma membrane. CO2‐sensitive traffic, dependent on trafficking by the SNARE SYP121, impacts stomatal gas exchange and plant growth.
Zhiyi Yu +4 more
wiley +1 more source
Functional polymorphisms in pigmentation-related genes <i>MC1R</i> and <i>DCT</i> display population-specific association with wet age-related macular degeneration. [PDF]
Reinisalo M +19 more
europepmc +1 more source
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli +6 more
wiley +1 more source
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl<sup>-</sup> currents in the early distal convoluted tubule of the mouse kidney. [PDF]
Hu L +6 more
europepmc +1 more source
The Expression and Potential Role of MicroRNAs in Oral Lichen Planus
ABSTRACT Background Oral lichen planus (OLP) is a chronic T‐cell‐mediated immune disease of unknown aetiology. MicroRNA (miRNAs) are short non‐coding RNAs capable of regulating mRNA and may have roles in T‐cell‐related diseases. The aim of this study was to investigate the profile of miRNAs in OLP patients and its interaction with potential target ...
Mousa Ali Heba +3 more
wiley +1 more source
Klotho in the kidney distal convolution regulates urinary Klotho excretion and kidney calcium reabsorption, but not phosphate homeostasis. [PDF]
Bourqui L +12 more
europepmc +1 more source
Heterogeneity of miRNAs in Salivary Gland Neoplasms: An Exploratory Pilot Study
ABSTRACT Introduction MicroRNAs (miRNAs) are small RNAs that have been associated with tumourigenesis and tumour progression and that play an important role in the pathogenesis of salivary gland neoplasms. The aim of this study was to evaluate the global miRNA expression profile in a sample of salivary gland neoplasms.
Dandara Andrade de Santana +11 more
wiley +1 more source

