Results 41 to 50 of about 38,586 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Feature reduction in federated learning for intrusion detection in IoT networks

Cybersecurity
The rapid growth of the Internet of Things (IoT) has significantly increased the complexity of device interactions, making IoT networks more vulnerable to sophisticated cyber threats.
Thien D. Nguyen, Ammar Alazab, Ansam Khraisat, Tony Jan   +3 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Direct splitting and merging of 2-D DCT in the DCT domain

Digital Signal Processing, 2004
An efficient method for splitting an 8x8 2-D DCT block into four 4x4, two 8x4 (or 4x8) 2-D DCT blocks is presented in this paper. The reverse direction (the ''merge'' case) also can be realized by inverse transposing the given matrix operations in the ''split'' case.
Yuh-Jue Chuang, Ja-Ling Wu
openaire   +1 more source

Designed Lewis Acid–Base Passivation for High Performance Perovskite Solar Cells

Advanced Functional Materials, EarlyView.
ABSTRACT Silicon's high cost and long energy payback time remain major barriers to the global expansion of solar power. In contrast, metal–halide perovskites offer abundant, solution‐processable absorbers, and have achieved efficiencies of 25%–30%, positioning them as strong competitors to silicon.
Afna Manaf, Hiba Shahulhameed, Bhabani Sankar Swain, Shengzhong (Frank) Liu, Adel Najar   +4 more
wiley   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

IWCD-PROPOSED IMAGE COMPRESSION METHOD BASED ON INTEGER WAVELET AND DCT [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2008
This paper describes a new lossy image compression decompression algorithm. In lossy compression techniques there are some loss of information, and image cannot be reconstructed exactly.This algorithm will be referred to as (IWDC), which stands for ...
Abdullah.M.Awad Al-Fahdawi
doaj   +1 more source

High capacity steganographic method based upon JPEG

, 2008
The two most important aspects of any image-based steganographic system are the quality of the stegoimage and the capacity of the cover image. This paper proposes a novel and high capacity steganographic approach based on Discrete Cosine Transformation (
Al-Mohammad, A, Adel Almohammad, Ghinea, G, Robert M. Hierons, Gheorghita Ghinea, Hierons, RM   +5 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Efficient hardware architectures for MPEG-4 core profile [PDF]

, 2005
Efficient hardware acceleration architectures are proposed for the most demandingMPEG-4 core profile algorithms, namely; texture motion estimation (TME), binary motion estimation (BME)and the shape adaptive discrete cosine transform (SA-DCT).
O'Connor, Noel E., Larkin, Daniel, O\u27Connor, Noel E., Muresan, Valentin, Kinane, Andrew   +4 more
core