Results 1 to 10 of about 19 (19)

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

open access: yesAdvanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan   +19 more
wiley   +1 more source

Consistent Choice of Prey Source Habitat Across Diverse Landscapes by a Selective Insectivorous Bat

open access: yesIntegrative Zoology, EarlyView.
After analyzing the diet of the greater horseshoe bats in three distinct colonies, we identified significant spatial and temporal differences, particularly noting a stronger reliance on riparian habitats in Mediterranean areas. The species exhibits great ecological adaptability with strong plasticity in prey source habitats, shifting preferences among ...
Miren Aldasoro   +7 more
wiley   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

open access: yesThe FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo   +16 more
wiley   +1 more source

Symbiosis‐associated UMAMIT transporters required for establishing efficient nitrogen fixation in Medicago truncatula

open access: yesNew Phytologist, EarlyView.
Summary To address a critical gap in understanding amino acid transport in legume–Rhizobium symbiosis, we investigated the role of symbiosis‐associated USUALLY MULTIPLE ACIDS MOVE IN AND OUT TRANSPORTERS (UMAMITs) in Medicago truncatula nodulation.
Courtney S. Winning   +8 more
wiley   +1 more source

Deep Learning Reconstruction for 129Xe Diffusion‐Weighted MRI Enables Use of Natural Abundant Xenon and Improved Image Acceleration

open access: yesMagnetic Resonance in Medicine, Volume 95, Issue 4, Page 2214-2222, April 2026.
ABSTRACT Purpose (i) To assess whether 129Xe apparent diffusion coefficient (ADC) and diffusive length scale (LmD) metrics are quantitatively preserved with deep learning (DL) accelerated acquisition and reconstruction and (ii) to evaluate the feasibility of 129Xe diffusion weighted imaging with natural‐abundance xenon at increased acceleration factors.
Rajagopalan Sundaresan   +6 more
wiley   +1 more source

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang   +4 more
wiley   +1 more source

An Efficient CO2‐Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate‐Utilizing Capacity via Adaptive Laboratory Evolution

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Chi Wang   +18 more
wiley   +1 more source

Real‐time specific absorption rate supervision for a 32‐channel RF transmit system with virtual observation points

open access: yesMagnetic Resonance in Medicine, Volume 94, Issue 6, Page 2785-2793, December 2025.
Abstract Purpose Real‐time supervision is a crucial element of an RF parallel transmit (pTx) system to supervise safety of the subject during MR imaging and to utilize the full potential of the RF array. However, the computational demand for the specific absorption rate (SAR) calculation scales much greater than linearly with the number of RF channels.
Thomas M. Fiedler   +10 more
wiley   +1 more source

Collective Response and Navigation Dynamics of Magnetospirillum gryphiswaldense under Rotating Magnetic Fields

open access: yesSmall, Volume 21, Issue 50, December 17, 2025.
The dynamics of Magnetospirillum gryphiswaldense under rotating magnetic fields are explored through the analysis of thousands of trajectories. The study reveals distinct navigation modes and transitions influenced by field strength and frequency. Directionality, alignment, and swimming behavior are examined to uncover how these microorganisms respond ...
Danny Villanueva   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +31 more
wiley   +1 more source

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