Results 11 to 20 of about 370,439 (113)

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response. [PDF]

FEBS J
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
González-Corralejo C, García-Sáez J, Figueroa-Fuentes M, Addante A, Roncero C, Lazcanoiturburu N, Pacheco B, Sanz J, Gato C, Fernández-Calderón E, López MO, González-Rodríguez Á, Porras A, Maina F, Fabregat I, Herrera B, Sánchez A.   +16 more
europepmc   +2 more sources

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte-Macrophage Crosstalk. [PDF]

Adv Sci (Weinh)
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Pan W, Yong Y, Li Y, Shi G, Zhang M, Wan L, Zhao Y, Zhan W, Lin Y, Qin Q, Chen X, Ni Y, Chen H, Shi W, Guo X, Chen J, Liu S, Wang Y, Liu B, Yan X.   +19 more
europepmc   +2 more sources

Methylglyoxal Affects Dopamine Homeostasis in SH-SY5Y Cells Through the Modulation of miR-190a and miR-214. [PDF]

FASEB J
In SH‐SY5Y cells, Methylglyoxal (MGO) reduces the intracellular dopamine content, up‐regulating the expression of proteins that modulate dopamine amount (MAO‐B, COMT, and α‐Syn). The MGO‐induced increase of COMT and α‐Syn expression is mediated by the reduction of miR‐214 and miR‐190a levels.
Croce A, Mirra P, Pignalosa FC, Zatterale F, Prevenzano I, Conza D, Ulianich L, Miele C, Beguinot F, Fiory F.   +9 more
europepmc   +2 more sources

Endothelial NAD⁺ depletion drives vascular senescence and neuroinflammation via mtDNA-cGAS/STING-CD38 signaling in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract BACKGROUND Endothelial dysfunction has emerged as early and pivotal event in Alzheimer's disease (AD), yet the molecular mechanisms linking vascular aging to neuroinflammation remain elusive. METHODS We used APP/PS1 mice and amyloid beta (Aβ)–challenged brain endothelial cells (BECs) to understand the mechanisms of nicotinamide adenine ...
Luo QH, Li F, Yang L, Pan HQ, Zhu WP, Hu P, Tao CM, Yin M, Zhang S, Liao QY, Chen ZH, Shu HX, Zhu XY, Yan TF, Liu X, Tu JL, Zhu XG.   +16 more
europepmc   +2 more sources

Report 2021 of the DDC at DKRZ

, 2022
This report provides statistics on the data downloads from the Reference Data Archive for climate model output hosted at the IPCC Data Distribution Centre (DDC) at DKRZ (http://ipcc.wdc-climate.de) for ...
Stockhause, Martina
core   +1 more source

HILT : a terminology mapping service with a DDC spine [PDF]

, 2006
The role of DDC in the ongoing HILT (High-level Thesaurus) project is discussed. A phased initiative, funded by JISC in the UK, HILT addresses an issue of likely interest to anyone serving users wishing to cross-search or cross-browse groups of networked
Shiri, A., Ali Shiri, Dawson, Alan, Nicholson, D., Shiri, Ali, Nicholson, Dennis, Dawson, A., Alan Dawson, Dennis M. Nicholson, Nicholson, Dannis M.   +9 more
core   +1 more source

DDC AR6 Reference Data Archival of CMIP6 input datasets

, 2023
A new directory and page with an overview over the data contained in the Reference Data Archive for AR6 at IPCC DDC Partner DKRZ was added.If you use this software, please cite it as ...
Stockhause, Martina, Krüss, Beate, Wachsmann, Fabian   +2 more
core   +1 more source

IPCC-DDC at WDC Climate / DKRZ [PDF]

, 2017
The talk given at the IPCC AR6 Data Workshop (19/20 September 2017) at DKRZ in Hambrug, Germany, between IPCC AR6 Working Group I and II TSUs and IPCC DDC Managers from BADC and WDCC/DKRZ gives an overview over the current data services within the IPCC ...
Lautenschlager, Michael, Stockhause, Martina, Lautenschlager, Michael (5061065), Stockhause, Martina (5061068), Kindermann, Stephan, Kindermann, Stephan (5365138)   +5 more
core   +1 more source

Minutes of the DDC Managers Subgroup from November 2019 to June 2021

, 2021
Minutes of the IPCC Task Group on Data (TG-DATA) subgroup for the DDC Managers. The period covered is from November 2019 to June 2021. The last set of minutes are for a meeting convened by CEDA and run by Metadatworks (who took the minutes for this ...
Martin Juckes
core   +1 more source

Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility

Angewandte Chemie, EarlyView.
Epimer discrimination remains challenging due to subtle NMR differences. Here, we propose a methodology based on 13C‐RCSA and RDC anisotropic parameters, enabling the assignment of two flexible tetraprenyltoluquinol epimers (1a and 1b) with remote stereoclusters.
Juan Carlos C. Fuentes‐Monteverde, Abel M. Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger   +6 more
wiley   +2 more sources