Results 11 to 20 of about 914 (62)

Methylglyoxal Affects Dopamine Homeostasis in SH-SY5Y Cells Through the Modulation of miR-190a and miR-214. [PDF]

FASEB J
In SH‐SY5Y cells, Methylglyoxal (MGO) reduces the intracellular dopamine content, up‐regulating the expression of proteins that modulate dopamine amount (MAO‐B, COMT, and α‐Syn). The MGO‐induced increase of COMT and α‐Syn expression is mediated by the reduction of miR‐214 and miR‐190a levels.
Croce A, Mirra P, Pignalosa FC, Zatterale F, Prevenzano I, Conza D, Ulianich L, Miele C, Beguinot F, Fiory F.   +9 more
europepmc   +2 more sources

An Efficient CO₂-Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate-Utilizing Capacity via Adaptive Laboratory Evolution. [PDF]

Adv Sci (Weinh)
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Wang C, Chen TT, Yang YJ, Li YX, Chang YX, Xiao YC, Guo WT, Zheng Y, Deng RZ, Tian YX, Situ W, Shen HW, Chen Y, Wang YB, Xing J, Wang H, Xia L, Lin YN, Ye JW.   +18 more
europepmc   +2 more sources

Real-time specific absorption rate supervision for a 32-channel RF transmit system with virtual observation points. [PDF]

Magn Reson Med
Abstract Purpose Real‐time supervision is a crucial element of an RF parallel transmit (pTx) system to supervise safety of the subject during MR imaging and to utilize the full potential of the RF array. However, the computational demand for the specific absorption rate (SAR) calculation scales much greater than linearly with the number of RF channels.
Fiedler TM, Orzada S, Grimm JA, Batkai B, Dinkelacker S, Kratzer FJ, Klein C, May MW, Mayer F, Schweins L, Ladd ME.   +10 more
europepmc   +2 more sources

Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity. [PDF]

J Inherit Metab Dis
ABSTRACT Tyrosine hydroxylase deficiency (THD) is a rare genetic disorder caused by biallelic pathogenic variants in the Th gene, leading to a deficiency in the rate‐limiting enzyme for the synthesis of dopamine (DA) and other catecholamine neurotransmitters.
Shi TS, Jung-Kc K, Lyu GW, Han L, Ying M, Thöny B, Martinez A.   +6 more
europepmc   +2 more sources

Mapping the Tissue-of-Origins of Mesenchymal Stromal Cells in Injury Repair. [PDF]

Adv Sci (Weinh)
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Tang XT, Liu YL, Du YA, Wang SS, Zhou BO.   +4 more
europepmc   +2 more sources

Prospecting of Architectural Features Using LiDAR‐UAV Technology, Deep Neural Networks and Visualization Techniques: A Case Study in Kuélap and Cambolín (NW Peru)

Archaeological Prospection, EarlyView.
ABSTRACT High‐resolution and accurate synoptic images of terrestrial topography, even in densely forested areas, have proven valuable for archaeology by enabling the identification and characterization of relief patterns associated with ancient human activities. This study presents a novel approach that integrates digital terrain models (DTMs) obtained
Jhon A. Zabaleta‐Santisteban, Rolando Salas López, Angel J. Medina‐Medina, Katerin M. Tuesta‐Trauco, Abner S. Rivera‐Fernandez, Nerci M. Noriega‐Salazar, José A. Sánchez‐Vega, Teodoro B. Silva‐Melendez, Marlen A. Grandez‐Alberca, Jhonsy O. Silva‐López, Nilton B. Rojas‐Briceño, Manuel Oliva‐Cruz, Alexander Cotrina‐Sanchez, Elgar Barboza   +13 more
wiley   +1 more source

Consistent Choice of Prey Source Habitat Across Diverse Landscapes by a Selective Insectivorous Bat

Integrative Zoology, EarlyView.
After analyzing the diet of the greater horseshoe bats in three distinct colonies, we identified significant spatial and temporal differences, particularly noting a stronger reliance on riparian habitats in Mediterranean areas. The species exhibits great ecological adaptability with strong plasticity in prey source habitats, shifting preferences among ...
Miren Aldasoro, Oihane Diaz de Cerio, Danilo Russo, Nerea Vallejo, Lander Olasagasti, Inazio Garin, Urtzi Goiti, Joxerra Aihartza   +7 more
wiley   +1 more source

Postprandial Glucagon Action in the Human Brain

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Elevated fasting glucagon is linked to hyperglycemia, but postprandial glucagon effects are less understood. Recent evidence suggests metabolic benefits of rising glucagon after oral glucose intake, potentially impacting brain‐mediated whole‐body metabolism.
Robert Wagner, Stephanie Kullmann, Julia Hummel, Katsiaryna Prystupa, Elena Hosenfeld, Ralf Veit, Andreas L. Birkenfeld, Hans‐Ulrich Häring, Hubert Preissl, Andreas Fritsche, Andreas Peter, Martin Heni   +11 more
wiley   +1 more source

Essential Role of Icosahedral Symmetry in the 3D Shape of AuAg Plasmonic Nanostars With High Aspect‐Ratio Legs

Small, Volume 22, Issue 27, 14 May 2026.
Electron nanodiffraction mapping was used to determine that the 3D leg configuration of branched plasmonic AuAg nanostars is associated with the icosahedral symmetry of the star core, providing a deeper understanding of their growth mechanism and thus paving the way to the development of optimized synthesis protocols targeting optical enhancement ...
Leonardo M. Corrêa, Simon M. Fairclough, Kaleigh M. R. Scher, Supriya Atta, Diego P. Dos Santos, Caterina Ducati, Laura Fabris, Daniel Ugarte   +7 more
wiley   +1 more source

Endothelial NAD+ depletion drives vascular senescence and neuroinflammation via mtDNA‐cGAS/STING‐CD38 signaling in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract BACKGROUND Endothelial dysfunction has emerged as early and pivotal event in Alzheimer's disease (AD), yet the molecular mechanisms linking vascular aging to neuroinflammation remain elusive. METHODS We used APP/PS1 mice and amyloid beta (Aβ)–challenged brain endothelial cells (BECs) to understand the mechanisms of nicotinamide adenine ...
Qing‐Hua Luo, Fang Li, Li Yang, Han‐Qing Pan, Wen‐Ping Zhu, Ping Hu, Chu‐Ming Tao, Min Yin, Si Zhang, Qiu‐Ye Liao, Zhi‐Hao Chen, Hong‐Xin Shu, Xin‐Yi Zhu, Teng‐Feng Yan, Xu Liu, Jiang‐Long Tu, Xin‐Gen Zhu   +16 more
wiley   +1 more source