Results 1 to 10 of about 914 (62)

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response. [PDF]

FEBS J
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
González-Corralejo C, García-Sáez J, Figueroa-Fuentes M, Addante A, Roncero C, Lazcanoiturburu N, Pacheco B, Sanz J, Gato C, Fernández-Calderón E, López MO, González-Rodríguez Á, Porras A, Maina F, Fabregat I, Herrera B, Sánchez A.   +16 more
europepmc   +2 more sources

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte-Macrophage Crosstalk. [PDF]

Adv Sci (Weinh)
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Pan W, Yong Y, Li Y, Shi G, Zhang M, Wan L, Zhao Y, Zhan W, Lin Y, Qin Q, Chen X, Ni Y, Chen H, Shi W, Guo X, Chen J, Liu S, Wang Y, Liu B, Yan X.   +19 more
europepmc   +2 more sources

Metabolic Pathway Reconstruction Indicates the Presence of Important Medicinal Compounds in <i>Coffea</i> Such as L-DOPA. [PDF]

Int J Mol Sci, 2023
Cherubino Ribeiro TH, de Oliveira RR, das Neves TT, Santiago WD, Mansur BL, Saczk AA, Vilela de Resende ML, Chalfun-Junior A.   +7 more
europepmc   +1 more source

Aromatic l-amino acid decarboxylase deficiency in Taiwan. [PDF]

JIMD Rep, 2023
Hwu WL, Hsu RH, Li MH, Lee HM, Chen HA, Lee NC, Chien YH.   +6 more
europepmc   +1 more source

GPR54 regulates non-small cell lung cancer development via dopa decarboxylase. [PDF]

Signal Transduct Target Ther
Hwang HH, Lee SY, Lee C, Lee JY, Ko SG, Cho SG.   +5 more
europepmc   +1 more source

Role of SQSTM1/p62 in regulating Mallory-Denk body in alcohol-associated liver disease. [PDF]

eGastroenterology
Hinz K, Qian H, Peiffer B, Sun Z, Ni HM, Ding WX.   +5 more
europepmc   +1 more source

Establishing a national indicator-based surveillance system for hospital bed utilization by COVID-19 patients in the Philippines. [PDF]

Western Pac Surveill Response J, 2023
Cabaro BS, Dela Paz GAT, Dotingco JB, Almirol BJQ, Borlongan GR, Cebreros ROD, Diangco PB, Quijalvo KPB, Tan JPU, Tonato RRD.   +9 more
europepmc   +1 more source

Ligase 3 prevents oxidative strand break-induced mitochondrial DNA loss but is not essential for replicative circularization. [PDF]

Nucleic Acids Res
Trombly G, Said AM, Kudin AP, Hallmann K, Kakabadze A, Peeva V, Becker K, Köhrer K, Zsurka G, Kunz WS.   +9 more
europepmc   +1 more source

G-quadruplex ligand RHPS4 compromises cellular radioresistance by inhibiting the mitochondrial adaptive response induced by ionizing irradiation. [PDF]

NAR Cancer
Tricot S, Siberchicot C, Bontemps I, Desmaze C, Kratassiouk G, Vandamme M, Pinna G, Nemazanyy I, Radicella JP, Lenaers G, Renaudin X, Lebeau J, Campalans A.   +12 more
europepmc   +1 more source

Genetically engineered BMSCs promote dopamine secretion and ameliorate motor dysfunction in a Parkinson's disease rat model. [PDF]

Sci Rep
Wang C, Liu Y, Chang J, He Y, Yang P, Fu J, Du W, Ma C, Liu G, Guo Y, Liu C.   +10 more
europepmc   +1 more source