Results 11 to 20 of about 9,356 (78)

Thermal extraction and characterization of pectin from semi‐solid by‐products of the olive oil industry

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The valorization of agro‐industrial by‐products is crucial for promoting sustainability and circular economy. Olive mill semi‐solid by‐products (OMSbP), also known as alperujo, contain valuable bioactive compounds, including pectin, which can be extracted and used in food applications.
Africa Fernandez‐Prior, Luna Barrera‐Chamorro, Elvira Marquez‐Paradas, Carol López‐de‐Dicastillo, Maria C. Millan‐Linares, Alvaro Villanueva‐Lazo, Sergio Montserrat‐de la Paz   +6 more
wiley   +1 more source

Citizen science informs demand‐driven breeding of opportunity crops

PLANTS, PEOPLE, PLANET, EarlyView.
Amid global challenges of food insecurity, poor nutrition, and climate change, neglected crops like amaranth are gaining renewed attention. We studied farmers' preferences for amaranth varieties across diverse geographical contexts to guide targeted breeding.
Rachel C. Voss, Kauê de Sousa, Sognigbé N'Danikou, Abdul Shango, Lys Amavi Aglinglo, Marie‐Angélique Laporte, Eric C. Legba, Aristide Carlos Houdegbe, Danfing dit Youssouf Diarra, Aminata Dolo, Amadou Sidibe, Colette Ouidyam Ouedraogo, Harouna Coulibaly, Enoch G. Achigan‐Dako, Aishi Kileo, Dickson Malulu, Zamira Matumbo, Fekadu Dinssa, Joost van Heerwaarden, Jacob van Etten, Amritbir Riar, Maarten van Zonneveld   +21 more
wiley   +1 more source

Human CD141+ dendritic cells: A unique tolerogenic subset inducing immune tolerance in systemic lupus erythematosus patients

Rheumatology &Autoimmunity, EarlyView.
Peripheral blood mononuclear cells were isolated from 12 systemic lupus erythematosus (SLE) patients and 12 healthy controls. The number and function of peripheral blood CD141+ dendritic cells (DCs) were compared between patients and controls. Moreover, the tolerogenic properties of CD141+ and CD1c+ DCs were compared in SLE patients.
Xiaodong Qin, Yujiao Wang, Yi Chen, Dong Xie, Xinran Yuan   +4 more
wiley   +1 more source

Microneedle delivery systems for vaccines and immunotherapy

Smart Molecules, EarlyView.
This paper reviews the preparation methods and materials of microneedles for drug delivery, summarizes the structures and types of microneedle systems, analyzes the influence of antigens and adjuvants on the efficacy of microneedle vaccines, and reviews the current application status of microneedles in the fields of vaccines and immunotherapy by ...
Haiyao Jia, Jinyuan Liu, Mengqian Shi, Manzar Abbas, Ruirui Xing, Xuehai Yan   +5 more
wiley   +1 more source

Evaluating the Therapeutic Potential of Superoxide Dismutase in a Rat Model of Wet Age‐Related Macular Degeneration

FASEB BioAdvances, EarlyView.
Oral Superoxide Dismutase Therapy Mitigates Choroidal Neovascularization in a Laser‐Induced Rat Model of Wet Age‐Related Macular Degeneration. Oral Administration of GF103, a Superoxide Dismutase From Bacillus amyloliquefaciens, Reduces Choroidal Neovascularization (CNV) in a Laser‐Induced CNV Rat Model.
Hyun Chul Jeong, Chang Sik Cho, Jeong Hyun Kim, Inik Chang, Jeong Hun Kim   +4 more
wiley   +1 more source

Clinical and Neurodevelopmental Characteristics of Paralogous Gain‐of‐Function Variants at GRIA2 p.Gly792 and GRIA3 p.Gly803

Clinical Genetics, EarlyView.
Key features of paralogous GRIA2 and GRIA3 gain‐of‐function variants. ABSTRACT GRIA‐related disorders arise from disease‐causing variants in GRIA1, GRIA2, GRIA3, or GRIA4 that encode α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA)‐type glutamate receptors (AMPARs).
Emilie Sjøstrøm, Dorota Studniarczyk, Xinyao Dou, Rebekka S. Dahl, Vincent Cruz, Heng Wang, Sandra Mercier, Wallid Deb, Thomas Besnard, Jennifer Friedman, Miriam Essid, Sana Karoui, Lamia Ben Jemaa, Thouraya Benyounes, Gaetan Lesca, Davide Tonduti, Maria Iascone, Simona Orcesi, Melanie Fradin, Christèle Dubourg, Silvia Napuri, Stuart G. Cull‐Candy, Ian D. Coombs, Mark Farrant, Allan Bayat   +24 more
wiley   +1 more source

Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis

Contact Dermatitis, EarlyView.
ABSTRACT Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should ...
Meital Portugal‐Cohen, Warangkana Lohcharoenkal, Evelyn Kelemen, Inge Kortekaas Krohn, Shauni De Vriese, Danuta Gutowska‐Owsiak, Ivone Jakasa, Dijana Furundžić, Anna Zalewska‐Janowska, Sandrine Dubrac   +9 more
wiley   +1 more source

Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids

Cell Proliferation, EarlyView.
A novel matrigel‐free suspension culture enhances the generation of high‐quality human liver ductal organoids, which shows remarkable efficacy in mice transplantation. ABSTRACT Liver transplantation is currently the sole definitive treatment option for end‐stage liver failure.
Senyi Gong, Kangxin He, Yu Liu, Xingyu Luo, Kamran Ashraf, Jinzhao He, Weifeng Li, Lihua Yang, Touseef Ur Rehman, Mingwei Shen, Qinbiao Yan, Ali Mohsin, Shusen Zheng, Zhe Yang, Meijin Guo   +14 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

The FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi   +11 more
wiley   +1 more source