Results 21 to 30 of about 9,356 (78)

A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia

Journal of Sleep Research, EarlyView.
Summary This double‐blind, placebo‐controlled, two‐way crossover trial evaluated the efficacy and safety of daridorexant in patients with chronic insomnia and comorbid nocturia. In total, 60 patients aged ≥55 years with insomnia complaints for ≥3 months, Insomnia Severity Index (ISI) ≥13 and ≥3 voids/night for ≥1 month were randomised (1:1) to ...
Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel   +9 more
wiley   +1 more source

Reproductive Barriers and Genomic Hotspots of Adaptation During Allopatric Species Divergence

Molecular Ecology, EarlyView.
ABSTRACT Theory predicts that in allopatric populations, genomic divergence and reproductive barriers may be driven by random genetic drift and thereby evolve slowly in large populations. However, local adaptation and divergence under selection may also play important roles, which remain poorly characterised.
Riddhi Deshmukh, Saurav Baral, Muktai Kuwalekar, Athulya Girish Kizhakke, Krushnamegh Kunte   +4 more
wiley   +1 more source

Examining the ‘gendered’ places and spaces of UK doctoral education using multilevel modelling

Transactions of the Institute of British Geographers, EarlyView.
Short Abstract Research on gender in higher education frequently focuses on either micro‐ or macro‐scale factors, such as power relations and working practices, or disciplinary norms and the educational ‘pipeline’. As a result, the connecting meso‐scale of ‘place’—embodied in the department and institution—is often missing both conceptually and ...
Laura Harriet Sheppard, Jonathan Reades, Richard P. J. Freeman   +2 more
wiley   +1 more source

Accuracy and interpretability of smartwatch electrocardiogram for early detection of atrial fibrillation: A systematic review and meta‐analysis

Journal of Arrhythmia, Volume 41, Issue 3, June 2025.
The smartwatch ECG algorithm achieved 86% sensitivity and 94% specificity with an sAUC of 96%, while manual readings by trained personnel reached 96% sensitivity, 95% specificity, and an sAUC of 98% in a brand‐specific subgroup analysis. These findings demonstrate that the smartwatch ECG detects AFib, although 3% of results are unreadable.
Muhammad Iqhrammullah, Asnawi Abdullah, Hermansyah, Fahmi Ichwansyah, Hafnidar A. Rani, Meulu Alina, Artha M. T. Simanjuntak, Derren D. C. H. Rampengan, Seba Talat Al‐Gunaid, Naufal Gusti, Arditya Damarkusuma, Edza Aria Wikurendra   +11 more
wiley   +1 more source

The Buyer Power Effect of Retail Mergers: An Empirical Model of Bargaining with Equilibrium of Fear

The RAND Journal of Economics, Volume 56, Issue 2, Page 194-215, Summer 2025.
ABSTRACT We develop a bilateral oligopoly framework with manufacturer‐retailer bargaining to analyze the impact of retail mergers on market outcomes. We show that the surplus division between manufacturers and retailers depends on three bargaining forces and can be interpreted in terms of an “equilibrium of fear”.
Céline Bonnet, Zohra Bouamra‐Mechemache, Hugo Molina   +2 more
wiley   +1 more source

Species that dominate spatial turnover can be of (almost) any abundance

Ecography, Volume 2025, Issue 6, June 2025.
An ongoing quest in ecology is understanding how species commonness influences compositional change. While each species' contribution to beta diversity (SCBD) depends both on its abundance and how widespread it is (e.g. occupancy) a general expectation for these influences is lacking. Using published data for 9924 species across 177 metacommunities, we
David C. Deane, Cang Hui, Melodie McGeoch   +2 more
wiley   +1 more source

VqERF1B‐VqERF062‐VqNSTS2 transcriptional cascade enhances stilbene biosynthesis and resistance to powdery mildew in grapevine

Plant Biotechnology Journal, Volume 23, Issue 6, Page 2065-2082, June 2025.
Summary Grapes, as one of the world's oldest economic crops, are severely affected by grape powdery mildew, causing significant economic losses. As a phytoalexin against powdery mildew, stilbenes and their key synthetic gene, stilbene synthase (STS), are highly sought after by researchers.
Chaohui Yan, Wandi Liu, Ruimin Li, Guotian Liu, Yuejin Wang   +4 more
wiley   +1 more source

Biomolecular Affinities and Cytotoxicity of Copper(I) and Silver(I) Phosphine–Pyridinyl Complexes Against CACO‐2 and CASKI Cell Lines

European Journal of Inorganic Chemistry, Volume 28, Issue 15, May 28, 2025.
This study reports Copper(I) and Silver(I) complexes with pyridinyl Schiff base ligands and triphenylphosphine. Their DNA/protein binding and in vitro cytotoxicity were evaluated. All complexes intercalated with calf thymus DNA, bound strongly to proteins, and showed notable cytotoxicity against Caco‐2 and Caski cancer cells, highlighting their promise
Adesola A. Adeleke, Miche D. Meyer, Nicole R. S. Sibuyi, Martin O. Onani, Bernard Omondi   +4 more
wiley   +1 more source

The knowledge driven DBTL cycle provides mechanistic insights while optimising dopamine production in Escherichia coli. [PDF]

Microb Cell Fact
Hägele L, Trachtmann N, Takors R.
europepmc   +1 more source

Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis. [PDF]

Elife
Jirouskova M, Harant K, Cejnar P, Ojha S, Korelova K, Sarnova L, Sticova E, Mayr CH, Schiller HB, Gregor M.   +9 more
europepmc   +1 more source