Results 21 to 30 of about 674 (66)

Deep Learning‐Enhanced Chemiluminescence Vertical Flow Assay for High‐Sensitivity Cardiac Troponin I Testing

Small, Volume 21, Issue 11, March 19, 2025.
This study presents a chemiluminescence vertical flow assay (CL‐VFA) for high‐sensitivity detection of cardiac troponin I (cTnI), a critical biomarker for assessing myocardial infarction. By integrating innovations in CL‐based sensing, portable reader‐based imaging, and deep learning analysis, the CL‐VFA achieves rapid, cost‐effective, and precise ...
Gyeo‐Re Han, Artem Goncharov, Merve Eryilmaz, Shun Ye, Hyou‐Arm Joung, Rajesh Ghosh, Emily Ngo, Aoi Tomoeda, Yena Lee, Kevin Ngo, Elizabeth Melton, Omai B. Garner, Dino Di Carlo, Aydogan Ozcan   +13 more
wiley   +1 more source

Prevalence and factors associated with dementia in Lesotho: A cross‐sectional, population‐based study

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Limited research has examined dementia prevalence and associated factors in Lesotho. This study investigates dementia prevalence and the associated factors in Lesotho. METHODS A survey in Lesotho included 1738 participants screened for dementia and potential associated factors with a focus on modifiable factors.
Natalie E. Johnson, Jennifer M. Belus, Felix Gerber, Tristan T. Lee, Irene Ayakaka, Pearl Letsoela, Manthabiseng Molulela, Frédérique Chammartin, Alain Amstutz, Niklaus D. Labhardt   +9 more
wiley   +1 more source

Gene therapy for genetic diseases: challenges and future directions

MedComm, Volume 6, Issue 2, February 2025.
The graphical abstract provides an overview of gene therapy approaches, detailing the components of the therapy and the various delivery routes. Both in vivo and ex vivo strategies facilitate the implementation of gene replacement, gene suppression, gene supplementation, and gene editing.
Beibei Qie, Jianghua Tuo, Feilong Chen, Haili Ding, Lei Lyu   +4 more
wiley   +1 more source

Increased Matrix Stiffness Promotes Slow Muscle Fibre Regeneration After Skeletal Muscle Injury

Journal of Cellular and Molecular Medicine, Volume 29, Issue 4, February 2025.
ABSTRACT The global prevalence of skeletal muscle diseases has progressively escalated in recent years. This study aimed to explore the potential role of matrix stiffness in the repair mechanisms following skeletal muscle injury. We observed an increase in muscle stiffness, a significant rise in the number of type I muscle fibres and a notable ...
Dongmei Wang, Jiahong Wu, Zeyu Xu, Jinning Jia, Yimei Lai, Zhihua He   +5 more
wiley   +1 more source

Melatonin Reduces Mito‐Inflammation in Ischaemic Hippocampal HT22 Cells and Modulates the cGAS–STING Cytosolic DNA Sensing Pathway and FGF21 Release

Journal of Cellular and Molecular Medicine, Volume 28, Issue 24, December 2024.
ABSTRACT Mitochondrial dysfunction is a key event in many pathological conditions, including neurodegenerative processes. When mitochondria are damaged, they release damage‐associated molecular patterns (DAMPs) that activate mito‐inflammation. The present study assessed mito‐inflammation after in vitro oxygen–glucose deprivation as a representation of ...
Silvia Carloni, Maria Gemma Nasoni, Anna Casabianca, Chiara Orlandi, Loredana Capobianco, Giorgia Natalia Iaconisi, Liana Cerioni, Sabrina Burattini, Serena Benedetti, Russel J. Reiter, Walter Balduini, Francesca Luchetti   +11 more
wiley   +1 more source

Deep‐Focus Earthquake Mechanisms at the Subducting Nazca Plate (Peru‐Brazil Border): Cold Slab Behavior in a Warm Plate

Earth and Space Science, Volume 11, Issue 10, October 2024.
Abstract We calculate focal mechanisms and centroid depths for deep‐focus earthquakes (DFEs) along the Peru‐Brazil border. We obtained a total of 28 focal solutions for events with magnitudes between 4.2 and 7.5 Mw and occurring between 2014 and 2022.
G. S. Leite Neto, J. Julià, G. A. Prieto   +2 more
wiley   +1 more source

UEG Week 2025 Moderated Posters

United European Gastroenterology Journal, Volume 13, Issue S8, Page S189-S802, October 2025.
wiley   +1 more source

UEG Week 2025 Poster Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
wiley   +1 more source

Monoexponential, biexponential, stretched exponential and diffusion kurtosis models of diffusion-weighted imaging: a quantitative differentiation of solitary pulmonary lesion. [PDF]

BMC Med Imaging
Wang K, Wu G.
europepmc   +1 more source

Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation. [PDF]

PLoS Biol
Vasseur L, Gheeraert C, Dubois-Chevalier J, Very N, Guille L, Bou Saleh M, Boulet C, Sobolewski C, Loyer P, Berthier A, Legrand N, Corlu A, Gnemmi V, Lasailly G, Leteurtre E, Galinousky D, Bongiovanni A, Taront S, Toft NI, Grøntved L, Tulasne D, Furlan A, Ntandja-Wandji LC, Staels B, Lefebvre P, Dubuquoy L, Eeckhoute J.   +26 more
europepmc   +1 more source