Results 1 to 10 of about 49,594 (99)

Exosomal microRNA-342-5p secreted from adipose-derived mesenchymal stem cells mitigates acute kidney injury in sepsis mice by inhibiting TLR9

Biological Procedures Online, 2023
Background Sepsis-related acute kidney injury (AKI) is an inflammatory disease associated with extremely high mortality and health burden. This study explored the possibility of exosomes secreted by adipose-derived mesenchymal stem cells (AMSCs) serving ...
Wei Liu, Chenghuan Hu, Buyao Zhang, Mingxia Li, F. Deng, Shuangping Zhao   +5 more
semanticscholar   +1 more source

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

The N6-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway

Molecular Cancer, 2022
Background Previous studies have shown that the N 6 -methyladenosine (m 6 A) modification enhances the binding ability of mRNAs/long noncoding RNAs (lncRNAs) to microRNAs (miRNAs), but the impact of this modification on the competitive endogenous RNA ...
Changwei Lin, M. Ma, Yi Zhang, Liang Li, Fei Long, Canbin Xie, Hua Xiao, Teng Liu, Buning Tian, Kaiyan Yang, Yihang Guo, Miao Chen, Jinjiang Chou, N. Gong, Xiaorong Li, G. Hu   +15 more
semanticscholar   +1 more source

Procedure-Specific Complications Associated with Ultrasound-Guided Erector Spinae Plane Block for Lumbar Spine Surgery: A Retrospective Analysis of 342 Consecutive Cases

Journal of Pain Research, 2022
Purpose Presumed benefits of erector spinae plane blocks (ESPB) include an enhanced safety profile and few complications. There are few large series, which report the incidence of complications associated with ESPB on a procedure-specific basis.
L. Oezel, A. Hughes, Ikenna Onyekwere, Zhaorui Wang, A. Arzani, I. Okano, Jiaqi Zhu, A. Sama, F. Cammisa, F. Girardi, E. Soffin   +10 more
semanticscholar   +1 more source

Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis

Journal of Translational Medicine, 2021
Background Cancer-associated fibroblasts (CAFs) play a pivotal role in regulating tumor progression by transferring exosomes to adjacent cells. Our aim was to clarify the role of LINC00659 encapsulated in CAFs-derived exosomes (CAFs-exo) in colorectal ...
Lin Zhou, Jian Li, Yaping Tang, Mei Yang
semanticscholar   +1 more source

Circulating Small Extracellular Vesicle-Derived miR-342-5p Ameliorates Beta-Amyloid Formation via Targeting Beta-site APP Cleaving Enzyme 1 in Alzheimer’s Disease

Cells, 2022
Alzheimer’s disease (AD) is a common neurodegenerative disorder with progressive cognitive impairment in the elderly. Beta-amyloid (Aβ) formation and its accumulation in the brain constitute one of the pathological hallmarks of AD.
Zhiwu Dong, Hongjun Gu, Qiang Guo, Xianglu Liu, Feifei Li, Huiling Liu, Li Sun, Huimin Ma, Kewen Zhao   +8 more
semanticscholar   +1 more source

Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1

Oxidative Medicine and Cellular Longevity, 2022
Acute myocardial infarction (AMI) is a complication of atherosclerosis‐related cardiovascular illness that is caused by prolonged ischemia. Circular RNAs (circRNAs) are concentrated in extracellular vesicles (EVs) and have been linked to cardiovascular ...
Jianbing Zhu, Zhaoyang Chen, Xiaoping Peng, Zeqi Zheng, Aiping Le, Junjie Guo, Leilei Ma, Hong-tao Shi, K. Yao, Shuning Zhang, Junbo Ge, Zhenzhong Zheng, Qian Wang   +12 more
semanticscholar   +1 more source

Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells

Pharmaceuticals, 2022
Osteosarcomas are the most common type of malignant bone tumor. These tumors are characterized by the synthesis of an osteoid matrix. Current treatments are based on surgery and combination chemotherapy.
C. Veys, M.A.S. Jammes, F. Redini, L. Poulain, C. Denoyelle, F. Legendre, P. Galéra   +6 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source