Results 31 to 40 of about 49,613 (116)

The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and PANX2

open access: yesInternational Journal of Molecular Sciences, 2020
Cardiovascular disease (CVD) correlates with inflammation and a reduction in circulating endothelial progenitor cells (cEPCs). Recently, CVD was shown to be the main cause of mortality in individuals with type 1 diabetes (T1DM).
Sabina L Ray   +6 more
semanticscholar   +1 more source

Framing consumer empowerment in the digital economy: From networks and engagement toward sustainable purchase

open access: yesBusiness Ethics, the Environment &Responsibility, Volume 34, Issue 4, Page 1011-1032, October 2025.
Abstract The current study investigates the influence of variety among online providers and customers' access to knowledge on consumer networks, consumer engagement, and sustainable purchasing. Emphasis is on the underlying relationships among these constructs in the digital economy, which has evolved into a complex structure of multifarious nodes and ...
Elena‐Mădălina Vătămănescu   +3 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

open access: yesMedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen   +4 more
wiley   +1 more source

miRNA-342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6

open access: yesInternational Journal of Molecular Medicine, 2019
Diabetic kidney disease (DKD) is one of the major microvascular complications in patients with type 1 and/or type 2 diabetes, the first cause of end-stage renal disease (ESRD) in several countries and regions.
Zhenhuan Jiang   +5 more
semanticscholar   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

open access: yesCell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan   +5 more
wiley   +1 more source

Gene therapy for genetic diseases: challenges and future directions

open access: yesMedComm, Volume 6, Issue 2, February 2025.
The graphical abstract provides an overview of gene therapy approaches, detailing the components of the therapy and the various delivery routes. Both in vivo and ex vivo strategies facilitate the implementation of gene replacement, gene suppression, gene supplementation, and gene editing.
Beibei Qie   +4 more
wiley   +1 more source

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

open access: yesToxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis   +9 more
semanticscholar   +1 more source

Global trends in opioid use for pain management in acute pancreatitis: A multicentre prospective observational study

open access: yesUnited European Gastroenterology Journal, Volume 12, Issue 8, Page 1114-1127, October 2024.
Abstract Background Since there is no current international consensus on the optimal approach for pain management in acute pancreatitis (AP), analgesic practices may vary across different healthcare settings. Objective This study explored global disparities in analgesic use, in particular opioids, during admission and at discharge in hospitalised AP ...
Cecilie Siggaard Knoph   +371 more
wiley   +1 more source

Advancements of non‐invasive imaging technologies for the diagnosis and staging of liver fibrosis: Present and future

open access: yesVIEW, Volume 5, Issue 4, August 2024.
The authors provide an in‐depth exploration of recent advancements in ultrasound imaging, computed tomography imaging, magnetic resonance imaging, nuclear medicine imaging, radiomics, and artificial intelligence within the field of liver fibrosis research.
Wenpeng Huang, Yushuo Peng, Lei Kang
wiley   +1 more source

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

open access: yesInternational Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin   +3 more
semanticscholar   +1 more source

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